Overexpression of EMMPRIN is associated with lymph node metastasis and advanced stage of non-small cell lung cancer: a retrospective study.

Background: Previous studies show that overexpression of EMMPRIN involved in the malignant biological behavior of tumors. This investigation was to disclose the expression status of EMMPRIN in non-small cell lung cancer (NSCLC) and its clinical value for the diagnosis of NSCLC.

Methods: The expression of EMMPRIN was examined using immunohistochemistry and enzyme-linked immunosorbent assay.

[The role of DNA double strains damage repairing mechanisms in high glucose-induced endothelial senescence].

Objective: To investigate the roles of DNA double stains damage repairing mechanisms in high glucose-induced cellular senescence.

Methods: Human umbilical vein endothelial cells (HUVECs) were incubated with different concentrations of glucose (5.5 mmol/L, 11 mmol/L, 22 mmol/L and 33 mmol/L) for 72 hrs before the assay of senescence-associated beta-galactosidase staining.

[Effects of testosterone substitution on metabolic syndrome-related factors in hypogonadal males: a meta-analysis].

Objective: To conduct a meta-analysis on the effects of testosterone on the related factors of metabolic syndrome in hypogonadal males.

Methods: Based on the principles and methods of Cochrane systematic reviews, we searched the PubMed (1980 to August 2009), Embase (1980 to August 2009), the Cochrane Central Register of Controlled Trials and CNKI (1995 to August 2009) , and handsearched some relevant journals and conference proceedings as well. We also identified randomized controlled trials addressing the use of testosterone for the treatment of hypogonadism, screened the retrieved studies according to the predefined inclusion and exclusion criteria, evaluated the quality of the included studies, and performed a meta-analysis on the results of homogeneous studies using the Cochrane Collaboration's RevMan 5.