Fiber-Optic Photoacoustic Gas Microprobe Based on Linear Spot-Type Multipass Cell.

A linear spot-type multipass cell-enhanced fiber-optic photoacoustic gas microprobe is proposed. To further reduce the volume of the gas chamber and enhance the photoacoustic signal, we designed the cross section of the photoacoustic tube as a slit with a height of 10 mm and a width of 1.5 mm.

A Novel Fault Diagnosis Method Using FCEEMD-Based Multi-Complexity Low-Dimensional Features and Directed Acyclic Graph LSTSVM.

Rolling bearings, as critical components of rotating machinery, significantly influence equipment reliability and operational efficiency. Accurate fault diagnosis is therefore crucial for maintaining industrial production safety and continuity. This paper presents a new fault diagnosis method based on FCEEMD multi-complexity low-dimensional features and directed acyclic graph LSTSVM.

Multimodal registration network with multi-scale feature-crossing.

Purpose: A critical piece of information for prostate intervention and cancer treatment is provided by the complementary medical imaging modalities of ultrasound (US) and magnetic resonance imaging (MRI). Therefore, MRI-US image fusion is often required during prostate examination to provide contrast-enhanced TRUS, in which image registration is a key step in multimodal image fusion.

Methods: We propose a novel multi-scale feature-crossing network for the prostate MRI-US image registration task.

Design of electromagnetic tracking system for puncture needle of an intelligent puncture robot.

Objectives: The puncture needle of an intelligent puncture robot must accurately reach the target location early in the diagnosis of benign and malignant nodules and in the puncture ablation of malignant tumors. To track the position and the orientation of the puncture needle tip, an electromagnetic tracking system based on adaptive adjustment of excitation intensity and lock-in amplification is proposed.

Methods: The system includes a time-sharing excitation device with multiple magnetic sources, a magnetic sensor, a signal processing device based on dual-phase lock-in amplifiers and a computing platform in the upper computer.

Bone marrow mesenchymal stem cells paracrine TGF-β1 to mediate the biological activity of osteoblasts in bone repair.

Background: Bone marrow mesenchymal stem cells (BMSCs) are an important source of seed cells for regenerative medicine and tissue engineering therapy. BMSCs have multiple differentiation potentials and can release paracrine factors to facilitate tissue repair. Although the role of the osteogenic differentiation of BMSCs has been fully confirmed, the function and mechanism of BMSC paracrine factors in bone repair are still largely unclear.

Total Synthesis of (+)-Alsmaphorazine C and Formal Synthesis of (+)-Strictamine: A Photo-Fries Approach.

A bioinspired photo-Fries/imine capture cascade reaction was developed in continuous-flow mode, which facilitated the rapid construction of a series of diversely functionalized 2,7-heterocycle-fused tetrahydrocarbazoles, the ubiquitous core structures embedded in strychnos and akuammiline-type monoterpene indole alkaloids. The synthetic utility of this novel method has been preliminarily explored by the first total synthesis of (+)-alsmaphorazine C and formal synthesis of (+)-strictamine in a concise and efficient manner.

Arthroscopic partial meniscectomy combined with medical exercise therapy versus isolated medical exercise therapy for degenerative meniscal tear: A meta-analysis of randomized controlled trials.

Background: Degenerative meniscal tear is a chronic disorder which presents with knee pain, swelling and loss of motion. It is currently unknown whether arthroscopic partial meniscectomy combined with medical exercise therapy is superior to isolated medical exercise therapy for degenerative meniscal tear.

Objective: To determine if medical exercise therapy alone is as effective as arthroscopic partial meniscectomy combined with medical exercise therapy in treating degenerative meniscal tear.

Mechanical Properties and Microstructures of Laser-TIG Welded ME21 Rare Earth Mg Alloy.

The microstructural and mechanical properties of laser-tungsten inert gas (TIG) hybrid welding of Mg alloy sheets for automobiles are investigated in the present work, including AZ31 and ME21, AZ31 and AZ31, ME21 and ME21, and corresponding comparisons were carried out. The results show that columnar crystals appear in the ME21/ME21 and ME21/AZ31 heat-affected zones, and no columnar crystals formed in the AZ31/AZ31 fusion zone under a constant heat ratio of arc to laser. Heat accumulation in a narrow area and the undercooling degree are the two main factors for the formation of columnar crystal.

TGF‑β1 promotes the osteoinduction of human osteoblasts via the PI3K/AKT/mTOR/S6K1 signalling pathway.

Transforming growth factor β1 (TGF‑β1) has been suggested to be a candidate cytokine in the field of bone tissue engineering. Cytokines serve important roles in tissue engineering, particularly in the repair of bone damage; however, the underlying molecular mechanisms remain unclear. In the present study, the effects of TGF‑β1 on the osteogenesis and motility of hFOB1.

Combined use of Serum miR-338-3p, Cartilage Oligomeric Matrix Protein and Chondroitin Sulfate-846 in the Early Diagnosis of Knee Osteoarthritis.

Background: In this study, the serum levels of miR-338-3p, COMP, and CS-846 were detected in the patients with KOA and healthy controls, to explore the value of miR-338-3p, COMP, and CS-846 in the early diagnosis of KOA.

Methods: Real-time PCR was carried out to evaluate the level of miR-338-3p in KOA patients and healthy controls. Spearman's correlation coefficient was performed to examine the correlation between the expression of miR-338-3p, COMP, and CS-846.

Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: In vitro simulation of the bone-repairing effect of Mg-based alloy implant.

Unlabelled: Mg-based alloys, as the potential orthopaedic implant, can self-degrade to avoid second operation for its remove, and enable to promote bone repair; however, the underlying molecular mechanisms remain unclear. In the present study, we examined the effect of Mg ions on osteogenesis, chemotaxis and anti-alkaline stress in hFOB1.19 human osteoblast cells to simulate bone-repairing effect of a biodegradable Mg-based alloy implant in vitro, and explored the regulatory role of the transient receptor potential melastatin 7 (TRPM7)/phosphoinositide 3-kinase (PI3K) signalling pathway in the process of Mg ion-induced bone repair by knockdown of TRPM7 and antagonizing PI3K activity.

Efficacy and safety of mildronate for acute ischemic stroke: a randomized, double-blind, active-controlled phase II multicenter trial.

Background And Objective: Mildronate, an inhibitor of carnitine-dependent metabolism, is considered to be an anti-ischemic drug. This study is designed to evaluate the efficacy and safety of mildronate injection in treating acute ischemic stroke.

Methods: We performed a randomized, double-blind, multicenter clinical study of mildronate injection for treating acute cerebral infarction.