Publications by authors named "Zhaochen Tong"
Prognositic value of anoikis and tumor immune microenvironment-related gene in the treatment of osteosarcoma.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2024
Article Synopsis
- Osteosarcoma is a serious bone cancer affecting mainly children and adolescents, and the study focuses on the role of a programmed cell death process called anoikis in understanding tumor metastasis and immune response within the tumor microenvironment.
- Researchers analyzed gene expression and clinical data from osteosarcoma patients, identifying significant anoikis-related genes that correlate with the tumor immune microenvironment and developing a model to predict patient survival risk.
- The study found 51 key anoikis-related genes, with three being crucial for prognosis, and noted differences in immune cell activity and signaling pathways between high-risk and low-risk patient groups in the context of the osteosarcoma microenvironment.
Purpose: To investigate the effect of TNF-α and FGF-2 in the fracture healing disorder of type 2 diabetes.
Design/methodology/approach: Rat diabetes-bone traction model was established to investigate the effect of type 2 diabetes on the fracture healing and the association of TNF-α and FGF-2 with the process. Serological examination was performed to detect the related diabetes indexes.
[Expression level of Dickkopf-1 protein in bone mesenchymal stem cells in Type 2 diabetic rats and its relationship with osteogenic activity].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
September 2018
To examine the growth activity and osteogenic differentiation of bone mesenchymal stem cells (BMSCs) in rats with Type 2 diabetes mellitus (T2DM) as well as the expression level of Dickkopf-1 (DKK-1) in bone marrow, and to explore the relationship between the osteogenic activity of BMSCs and the expression of DKK-1. Methods: The BMSCs were isolated from T2DM rats and were cultured in vitro. The BMSCs were divided into a T2DM group and a control group.
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