Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular processes, intracellular signaling, and electron transfer. It is crucial to maintain intracellular metal ion homeostasis which is achieved by the subtle balance of storage and release of metal ions intracellularly along with the influx and efflux of metal ions at the interface of the cell membrane. Dysregulation of intracellular metal ions has been identified as a key mechanism in triggering programmed cell death (PCD).
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October 2024
Objective: To explore the feasibility of screening potential drugs for the treatment of diabetic kidney disease (DKD) using a single-cell transcriptome sequencing dataset and Connectivity Map (CMap) database screening.
Methods: A DKD single-nucleus transcriptome sequencing dataset was analyzed using Seurat 4.0 to obtain specific podocyte subclusters and differentially expressed genes (DEGs) related to DKD.
Photoelectrochemical (PEC) water splitting has been regarded as a promising technology for sustainable hydrogen production. The development of efficient photoelectrode materials is the key to improve the solar-to-hydrogen (STH) conversion efficiency towards practical application. Bismuth vanadate (BiVO) is one of the most promising photoanode materials with the advantages of visible light absorption, good chemical stability, nontoxic feature, and low cost.
View Article and Find Full Text PDFBackground: Former Detroit Red Wing Gordie Howe received stem cell (SC) treatment in Mexico in December 2014 for a stroke he suffered in October 2014. The news about his positive response to the SC treatment prompted discussion on social networks like Twitter.
Objective: This study aims to provide information about discussions that took place on Twitter regarding Howe's SC treatment and SC treatment in general.