Publications by authors named "Zhaobi Fang"
Background: Irinotecan (IRI) is a common chemotherapeutic drug for colorectal cancer; however, the mechanism underlying its immunomodulatory effect remains unclear. Curcumin (CUR), an adjuvant drug with anti-inflammatory and antitumor effects, has been studied extensively, although its synergistic antitumor effect remains unclear.
Methods: The effects of CUR and IRI on oxidative stress and their antitumor effects were detected by flow cytometry.
The application of traditional chemotherapy drugs for lung cancer has obvious limitations, such as toxic side effects, uncontrolled drug-release, poor bioavailability, and drug-resistance. Thus, to address the limitations of free drugs and improve treatment effects, we developed novel T7 peptide-modified nanoparticles (T7-CMCS-BAPE, CBT) based on carboxymethyl chitosan (CMCS), which is capable of targeted binding to the transferrin receptor (TfR) expressed on lung cancer cells and precisely regulating drug-release according to the pH value and reactive oxygen species (ROS) level. The results showed that the drug-loading content of docetaxel (DTX) and curcumin (CUR) was approximately 7.
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- The study aims to explore the genetic connections between periodontitis, a common gum disease, and Alzheimer's disease (AD), suggesting that periodontitis may contribute to the progression of AD.
- Researchers analyzed gene expression data to identify differentially expressed genes (DEGs) linked to periodontitis and compared them with genes associated with AD to find shared "crosstalk genes."
- A total of 48 representative crosstalk genes were identified, along with key regulators and pathways, highlighting potential genetic links between the two diseases, with specific shared genes like C4A and IL1B noted for further research.