3D Hydrogel Coculture System Provides Mechanistic Insights into Prostate Cancer Bone Metastasis.

Patients diagnosed with advanced prostate cancer (PCa) often experience incurable bone metastases; however, a lack of relevant experimental models has hampered the study of disease mechanisms and the development of therapeutic strategies. In this study, we employed the recently established erature-based -separable () 3D cell coculture system to investigate PCa bone metastasis. Through coculturing PCa and bone cells for 7 days, our results showed a reduction in PCa cell proliferation, an increase in neovascularization, and an enhanced metastasis potential when cocultured with bone cells.

Magnetically Driven Hierarchical Alignment in Biomimetic Fibrous Hydrogels.

In vivo, natural biomaterials are frequently anisotropic, exhibiting directional microstructures and mechanical properties. It remains challenging to develop such anisotropy in synthetic materials. Here, a facile one-step approach for in situ fabrication of hydrogels with hierarchically anisotropic architectures and direction-dependent mechanical properties is proposed.

A Temperature-Based Easy-Separable (TempEasy) 3D Hydrogel Coculture System.

Interactions between different cell types are crucial for their behavior in tissues, but are rarely considered in 3D in vitro cell culture experiments. One reason is that such coculture experiments are sometimes difficult to perform in 3D or require specialized equipment or know-how. Here, a new 3D cell coculture system is introduced, TempEasy, which is readily applied in any cell culture lab.

Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting.

T-cell acute lymphoblastic leukemia causes a disproportional amount of immature white blood cells in the patients' bone marrow. The significant undesired side effects associated with traditional chemotherapy treatment prompted us to study a more effective treatment strategy. We decorated polyisocyanopeptide scaffolds with the selective leukemia cell binding aptamer sgc8c and found that the polymers inhibit proliferation by G0/G1-phase arrest, serving as an opportunity for future therapeutic strategies.

Mesoporous and Nanostructured TiO layer with Ultra-High Loading on Nitrogen-Doped Carbon Foams as Flexible and Free-Standing Electrodes for Lithium-Ion Batteries.

A simple and green method is developed for the preparation of nanostructured TiO supported on nitrogen-doped carbon foams (NCFs) as a free-standing and flexible electrode for lithium-ion batteries (LIBs), in which the TiO with 2.5-4 times higher loading than the conventional TiO -based flexible electrodes acts as the active material. In addition, the NCFs act as a flexible substrate and efficient conductive networks.

[Advances in high-throughput transcriptome research of traditional Chinese medicines].

Traditional Chinese medicine is a treasure of Chinese culture, absorbing the wisdom of the Chinese people. Continuous application of new technologies makes traditional Chinese medicine research advance with the times. After several years of development, high-throughput transcriptome study has become a mature research tool in biology.

Discovery of a strongly-interrelated gene network in corals under constant darkness by correlation analysis after wavelet transform on complex network model.

Coral reefs occupy a relatively small portion of sea area, yet serve as a crucial source of biodiversity by establishing harmonious ecosystems with marine plants and animals. Previous researches mainly focused on screening several key genes induced by stress. Here we proposed a novel method--correlation analysis after wavelet transform of complex network model, to explore the effect of light on gene expression in the coral Acropora millepora based on microarray data.

Complete mitochondrial genome of Costaria costata shows conservative evolution in Laminariales.

Costaria costata, with great commercial and industrial value, typically grows in low intertidal and subtidal retgions in East Asia. The complete mitochondrial genome of C. costata is determined as circular-mapping and AT-rich (65%).