Publications by authors named "ZhaoHui Dai"
Article Synopsis
- Intimal hyperplasia (IH) is a major issue in vascular interventions, and this study investigates the role of gangliosides GA2 in its development.
- Researchers found that GA2 levels were significantly higher in atherosclerotic mouse aortae and plasma, and injecting GA2 worsened IH by interacting with macrophages.
- The study reveals that GA2 activates caspase-4 and promotes pyroptosis in macrophages, suggesting a new mechanism for IH that could lead to potential diagnostic and treatment strategies.
Oxidative stress is a primary contributor to cerebral ischemia/reperfusion (CI/R) injury, and the use of antioxidants represents a crucial therapeutic strategy for managing CI/R injury. This study aims to explore the antioxidant effects of benzyl ferulate on CI/R injury and elucidate its underlying mechanisms. In vivo models of CI/R injury and hypoxia/reoxygenation (H/R) injury in SH-SY5Y cells were established, followed by treatment with benzyl ferulate.
View Article and Find Full Text PDFPTEN/AKT signaling plays pivotal role in myocardial ischemia reperfusion injury (MIRI), and miRNAs are involved in the regulation of AKT signaling. This study was designed to investigate the interaction between miR-129 and PTEN in MIRI. A MIRI rat model and a hypoxia reoxygenation (H/R) H9C2 cell model were constructed to simulate myocardial infarction clinically.
View Article and Find Full Text PDFArticle Synopsis
- Patients with type 2 diabetes mellitus (T2DM) experience worse clinical outcomes after Percutaneous Coronary Intervention (PCI) compared to those without diabetes, as shown by a meta-analysis of 139,774 participants.
- The analysis revealed significantly higher rates of in-hospital mortality and major adverse cardiac events (MACEs) in the T2DM group, as well as greater short and long-term adverse events like stent thrombosis.
- Overall, patients with T2DM post-PCI face increased risks of serious complications, indicating the need for careful management and monitoring in this population.
1-[Bis(4-fluoro-phen-yl)meth-yl]-4-[2-(2-methyl-phen-oxy)eth-yl]piperazine.
Acta Crystallogr Sect E Struct Rep Online
April 2012
Article Synopsis
- The molecule has the formula C(26)H(28)F(2)N(2)O and includes a piperazine ring in a chair conformation.
- The substituents attached to the nitrogen are oriented equatorially, which increases stability.
- The dihedral angle between the two fluoro-benzene rings is measured at 69.10 degrees, indicating their spatial arrangement relative to each other.
A novel codrug (LMX) was obtained from lamivudine (LMV) and ursolic acid (UA) coupled with ethyl chloroacetate through an amide and ester linkage. The structure of LMX was confirmed by ¹H NMR, ¹³C NMR, IR and HRMS. Herein, the in vitro non-enzymatic and enzymatic hydrolysis and in vivo pharmacological activities of LMX were studied.
View Article and Find Full Text PDFArticle Synopsis
- The compound with the formula C(28)H(50)O(5)·H(2)O has a penta-cyclic triterpene structure, where all six-membered rings are in chair conformations.
- In the crystal structure, molecules are connected through hydrogen bonds, specifically O-H⋯O and C-H⋯O interactions.
- The presence of water (H2O) indicates that the compound exists as a hydrate, playing a role in its crystal formation.
(E)-1-{4-[Bis(4-meth-oxy-phen-yl)meth-yl]piperazin-1-yl}-3-(4-fluoro-phen-yl)prop-2-en-1-one.
Acta Crystallogr Sect E Struct Rep Online
February 2011
Article Synopsis
- The compound C(28)H(29)FN(2)O(3) has an E configuration around the ethene bond.
- The piperazine ring in the structure takes on a chair conformation.
- In the crystal structure, the molecules are held together by inter-molecular C-H⋯O hydrogen bonds.
Objective: To study the succession of sarcosaphagous insects and their regular activity on carcass in Shijiazhuang area.
Methods: Nine rabbits were sacrificed and placed at the same site during June to September in 2007-2009. The common species of sarcosaphagous insects were observed.