BATF Interference Blocks Th17 Cell Differentiation and Inflammatory Response in Hepatitis B Virus Transgenic Mice.

Background: B cell-activating transcription factor (BATF) contributes to Th17 cell differentiation and pathological inflammatory responses.

Aims: This study explored BATF as a regulator of Th17 differentiation in normal and hepatitis B virus (HBV) transgenic mice.

Methods: Normal mice were divided into control, short hairpin RNA (shRNA) scramble, and shRNA BATF groups.

Increased frequency of circulating Th17 cells in acute-on-chronic hepatitis B liver failure.

Background: T helper (Th) 17 cells participate in the pathogenesis of liver diseases but their exact role in acute-on-chronic hepatitis B liver failure (ACHBLF) still remains obscure.

Aims: This present study was aimed to characterize the circulating Th17 cells and to analyze their association with disease progression in ACHBLF.

Methods: This retrospective study consisted of 40 ACHBLF patients, 40 chronic hepatitis B (CHB) patients and 20 healthy controls.

[The analysis of IL-10 and its methylation in the patients with acute on chronic liver failure].

Objective: To investigate the effect of IL-10 and the methylation of its promoter in acute on chronic liver failure (ACLF).

Methods: Patients were divided into three groups: 25 with ACLF, 25 with CHB, 10 healthy controls. Respectively detect the serum level of IL-10 via ELISA, and the methylation of IL-10 promoter via MSP, to analyze the difference among the three groups.

Implication of Th17 and Th1 cells in patients with chronic active hepatitis B.

Objective: The pathogenesis of hepatitis B virus (HBV)-associated chronic liver disease is still not fully understood. The immune imbalance of cytokine profile exerts a profound influence on the resolution of HBV infections and HBV clearance. This present study aimed to evaluate the immune status of the peripheral T helper (Th) 17 and Th1 cells in the active patients with chronic HBV infection.