pH-Responsive Amphiphilic Triblock Fluoropolymers as Assemble Oxygen Nanoshuttles for Enhancing PDT against Hypoxic Tumor.

Photodynamic therapy (PDT) is a cancer treatment strategy that utilizes photosensitizers to convert oxygen within tumors into reactive singlet oxygen (O) to lyse tumor cells. Nevertheless, pre-existing tumor hypoxia and oxygen consumption during PDT can lead to an insufficient oxygen supply, potentially reducing the photodynamic efficacy. In response to this issue, we have devised a pH-responsive amphiphilic triblock fluorinated polymer (PDP) using copper-mediated RDRP.

Concurrent mutations of germline GPR101 and somatic USP8 in a pediatric giant pituitary ACTH adenoma: a case report.

Background: Cushing's disease (CD) is rare in pediatric patients. It is characterized by elevated plasma adrenocorticotropic hormone (ACTH) from pituitary adenomas, with damage to multiple systems and development. In recent years, genetic studies have shed light on the etiology and several mutations have been identified in patients with CD.

Somatostatin Treatment for Ectopic ACTH Syndrome due to Pancreatic Neuroendocrine Tumors: Review of the Literature.

Objectives: To analyze and summarize the effect of SSA treatment on EAS due to p-NETs (EAS-p-NETs).

Methods: Thirteen patients with EAS-p-NETs treated with SSAs at our center or described in the literature were included in this study. Clinical characteristics, laboratory data, imaging studies, histopathologic results, the effect of SSA treatment, and the prognosis of these EAS-p-NET patients were evaluated.

Cushing's disease with pulmonary Cryptococcus neoformans infection in a single center in Beijing, China: A retrospective study and literature review.

Background: Patients with Cushing's disease (CD) with hypercortisolism have an increased risk of opportunistic infection. However, most CD patients exposed to infections are diagnostic latency, leading to a poor prognosis.

Methods: Six patients in our hospital and an additional six patients in the literature were included in this study.

Detailed Componential Characterization of Extractable Species with Organic Solvents from Wheat Straw.

Componential analysis of extractives is important for better understanding the structure and utilization of biomass. In this investigation, wheat straw (WS) was extracted with petroleum ether (PE) and carbon disulfide (CS) sequentially, to afford extractable fractions EF and EF, respectively. Detailed componential analyses of EF and EF were carried out with Fourier transform infrared (FTIR) spectroscopy, gas chromatography/mass spectrometry (GC/MS), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), energy dispersive spectrometry (EDS), and electron probe microanalysis (EPMA).

[Characteristics of Soil Respiration and Soil Organic Carbon in Fava Bean Farmland Under Ridge Tillage and Straw Mulching in Southwest China].

Soil respiration is an important process for carbon emission. A field study was conducted with four treatments including T (traditional tillage+straw mulching level 0 kg·hm), R (ridge tillage+straw mulching level 0 kg·hm), RS1 (ridge tillage+straw mulching level 3750 kg·hm), and RS2 (ridge tillage+straw mulching level 7500 kg·hm), so as to probe the effects of ridge tillage and straw mulching amount on soil respiration and soil organic carbon(SOC) and the relationships of soil respiration rate with soil temperature and water content (SWC) during the growth period of fava bean in the triple intercropping system of fava bean/maize/sweat pomato in dryland region of southwest China known as the purple hilly region. The changes of soil respiration rate were in accordance with crop growing, being firstly increased and then decreased during the whole growth period of fava bean, and there were significant differences in soil respiration rate among different treatments, which could be ranked as RS2[3.

[Effects of Green Manure Intercropping and Straw Mulching on Winter Rape Rhizosphere Soil Organic Carbon and Soil Respiration].

Under the background of global warming, the farmland soil respiration has become the main way of agricultural carbon emissions. And green manure has great potential to curb greenhouse gas emissions and achieve energy conservation and emissions reduction. However, in purple soil region of Southwest, China, soil respiration under green manure remains unclear, especially in the winter and intercropping.

[A compound heterozygous mutation in CYP17A1 gene in a female subject with partial 17α-hydroxylase/17, 20 lyase deficiency].

Objective: To explore the clinical and molecular genetic characteristics of a Chinese female patient with partial 17α-hydroxylase/17, 20 lyase deficiency (17OHD), a rare type of congenital adrenal hyperplasia.

Methods: Her clinical features and laboratory data were collected. Genomic DNA was extracted from leukocytes of peripheral blood of her and her mother.

Growth and development of adolescent patients with Cushing's syndrome.

Objective: To elucidate the growth and development of patients with Cushing's syndrome (CS) in adolescence.

Methods: We analyzed the clinical data of 19 patients aged under 18 with CS. We divided the patients into two groups according to the height at diagnosis.

[The relationship between hyperlipidemia and lower limb arterial disease in elderly diabetes patients].

Objective: To evaluate the correlation between hyperlipidemia and lower limb arterial disease in elderly diabetic patients with color Doppler ultrasonography.

Methods: Two hundred and sixty elderly diabetic patients and 206 normal subjects were enrolled in the study. Doppler ultrasonographic manifestations of lower limb arterial disease, blood pressure and blood biochemistry parameters including fasting plasma glucose (FPG), postprandial plasma glucose (PPG), TC, TG, HLD-C, LDL-C, apoprotein B (apoB), very low density lipoprotein cholesterol (VLDL-C), apoprotein A1 (apoA1) and fibrinogen (Fb) were compared between the 2 groups.

[Incomplete P450 17 alpha enzyme deficiency: report of six cases].

Objectives: To summarize the characteristics, differential diagnosis and management of incomplete 17 alpha-hydroxylase/17, 20-lyase deficiency (17 OHD) of Chinese patients.

Methods: Six cases of incomplete 17 OHD from Peking Union Medical College Hospital were studied retrospectively through analyzing their clinical data, and the molecular pathogenic mechanism was discussed after literature review.

Results: Four cases of 46, XX incomplete 17 OHD were reported.

[Brief introduction of the construction of legal system of traditional Chinese medicine in modern China].

Since the foundation of PRC, the people's government attaches great importance to the development of traditional Chinese Medicine. With the efforts of people from Chinese medicine and the Party Central Committee's concern, the legal system of traditional Chinese medicine has been progressing step by step. Since 1949, the construction of legal system of traditional Chinese medicine can be divided into three periods with lessons and achievements, each with its own features.

[Bone loss is more severe in younger Cushing's syndrome women than in older ones: comparison of bone mineral density between Cushing's syndrome and healthy women].

Objective: To investigate the influence of age on bone mass in Cushing's syndrome patients.

Methods: Measurement of bone mineral density (BMD) was conducted among 57 women with Cushing's syndrome (CS) and 49 healthy women. There were 14 CS women and 14 healthy women in the group aged 20 - 29; 27 CS women and 15 healthy women in the group aged 30 - 39; and 16 CS women and 20 healthy women in the group aged 40 - 49.

[New compound heterozygous mutation causes partial combined 17 alpha-hydroxylase/17,20-lyase deficiency].

Objective: To investigate the CYP17A1 gene mutations in a Chinese 46,XX patient with partial combined 17 alpha-hydroxylase/17,20-lyase deficiency.

Methods: Clinical data were retrospectively analyzed. The genomic DNA of the patient and her parents was isolated from whole blood.

[A neglected master on integrative medicine: Wei-Ju ZHU].

Through analyzing the academic ideas in Shanghan Zhinan written by Wei-Ju ZHU, a modern famous physician, it is pointed out that ZHU's achievement on integrative medicine has been overlooked. Taking the theory of syndrome differentiation of six channels from Shanghan Lun as an example, ZHU presumed that the essence of therapeutic theory of traditional Chinese medicine was to conform to or strengthen human body's self-healing and self-regulating abilities. Since Yangqi is the major force in the body to help heal disease when it occurred, ZHU often took measures to strengthen Yang first in treating disease and also was good at using hot-natured herbs, such as Radix aconiti lateralis preparata.

Study on the genetic mutations of 17 alpha-hydroxylase/17,20-lyase deficiency in Chinese patients.

Objective: To investigate the CYP17A1 gene mutations in Chinese patients with 17 alpha-hydroxylase/17, 20-lyase deficiency.

Methods: Clinical data were retrospectively analyzed. The CYP17A1 gene mutations were detected in 5 cases with 17 alpha-hydroxylase/17, 20-lyase deficiency and their relatives.

Effects of chai hu (radix burpleuri) containing formulation on plasma beta-endorphin, epinephrine and dopamine on patients.

Chai Hu (Radix Burpleuri), a major ingredient in many traditional Chinese medicine formulas, such as Xiao Yan Wan, is used in the treatment of liver stagnation and spleen deficiency syndrome (LSSDS). The objectives of this study were to examine the effects of Xiao Yao Wan containing Chai Hu on the changes of plasma indices in patients with LSSDS. Fifty-eight cases of LSSDS were randomly divided into two groups: 41 cases in the experimental group were treated with Xiao Yao Wan containing Chai Hu and 17 cases in the control group were treated with Zhi Bai Di Huang Wan for one consecutive month in a single blind design.

[Clinical characteristics of 17alpha-hydroxylase/17,20-lyase deficiency and long term follow up results].

Objective: To improve the diagnosis and the treatment level of 17alpha-hydroxylase/17,20-lyase deficiency.

Methods: 24 patients suffering from this disease were diagnosed and treated in Peking Union Medical College Hospital from 1978 to 2002. All the patients had comprehensive hormone assay and some had bone mineral density detection.

[Molecular characterization of mutations and phenotype/genotype correlation in Chinese patients with 21-hydroxylase deficiency].

To investigate characteristics of CYP21 mutations in Chinese patients with 21-hydroxylase deficiency (21-OHD) and the relationship between genotype and phenotype, a time saving, reliable molecular diagnosis method was developed. Eight patients with NC 21-OHD, 35 patients with classical ones and 34 normal controls were studied as followed: CYP21 gene was amplified into fragment 1 (exon1 --> exon3) and fragment 2 (exon3 --> exon10) through PCR with specific primers. The second round PCR was carried out using fragment 1 and 2 as template, and PCR products were digested by restrictive enzymes to analyze nine mutations, including Del, Exon3 Del8 bp, Q318X, R356W, Exon6Cluster, i2g, l172N, P30L and V281L.

[The evaluation of the diagnosis and treatment of 32 cases with ectopic ACTH syndrome].

Objective: To investigate and discuss the diagnosis and treatment of ectopic ACTH syndrome.

Methods: Clinical data of 32 cases of ectopic ACTH syndrome, recruited from January 1990 to April 2003 in our hospital, was analyzed.

Results: All of the 32 cases presented with clinical and biochemical evidences of Cushing's syndrome.