Publications by authors named "Zhao-jiang Lu"
[Pollution Level and Risk Assessment of OPEs in Typical River Basins of China].
Huan Jing Ke Xue
December 2023
Organophosphate esters(OPEs), as a substitute for brominated flame retardants, are widely used in production and life, and their environmental pollution and toxic effects have attracted widespread attention. In this study, the concentrations and distribution characteristics of OPEs in seven major drainage basins of China were sorted out. The average daily dose of OPEs in Chinese adults, adolescents, and children was calculated to assess the health risks, and the reliability of the results was evaluated using Monte Carlo simulation.
View Article and Find Full Text PDF[Comparison of capabilities of survival, proliferation and expansion between CD34+CD59+ cells from patients with PNH and CD34+ cells from normal control].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
October 2002
Article Synopsis
- The study aimed to investigate the in vitro expansion of CD34+CD59+ cells from patients with PNH and compare their survival and growth to CD34+ cells from healthy individuals.* -
- Results showed that CD34+CD59+ cells from PNH patients could be expanded effectively, achieving a maximum of about 23.49 times expansion by day 7, with some similarities to CD34+ cells from controls in terms of growth factors needed for expansion.* -
- However, CD34+ cells from normal controls demonstrated better proliferation and survival capabilities compared to CD34+CD59+ cells from PNH patients, indicating that the latter are not fully normal cells.*
Article Synopsis
- This study investigates the properties of specific bone marrow cells (CD(34)(+) CD(59)(+)) in patients with paroxysmal nocturnal hemoglobinuria (PNH) and examines why PNH clones dominate hematopoiesis.
- Methods included sorting bone marrow cells using a specialized technique and culturing them to analyze their growth and survival characteristics.
- Results indicated that while normal cells showed better growth and survival rates, both PNH cell types had similar yields in certain culture conditions; however, CD(34)(+) CD(59)(-) cells performed better under specific growth factor combinations.
Article Synopsis
- * This method involved a two-step selection process where microbeads were removed from initially selected CD34(+) cells to allow for ex vivo expansion.
- * Results indicated that the survival and growth of the cells sorted through this method were comparable to those sorted by flow cytometry, suggesting it is a viable technique for preparing hematopoietic stem/progenitor cells for transplantation in PNH patients.
[GPI-Pr Deficiency and Apoptosis of PNH Granulocytes].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
September 2001
Article Synopsis
- - The study aimed to examine how Glycosyl phosphatidylinositol anchored proteins affect apoptosis in cells from patients with paroxysmal nocturnal hemoglobinuria (PNH) compared to normal controls.
- - Peripheral granulocytes from 10 PNH patients and 10 healthy individuals were analyzed, revealing that normal cells showed higher apoptosis rates (78.6%) than PNH cells (39.5%) when subjected to serum starvation.
- - Further analysis indicated that PNH granulocytes are relatively resistant to apoptosis, as evidenced by lower percentages of PI positivity and DNA fragmentation, and this resistance does not appear to be linked to CD59 deficiency levels.