Publications by authors named "Zhao-hua Dou"
[Regulatory Role of Nitric Oxide in Development and Hatching of Mouse Blastocysts].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
October 2015
Objective: To determine the regulatory role and mechanism of nitric oxide (NO) in the development and hatching of mouse blastocysts.
Methods: The Kunming female mice were superovulated and then mated with mature male mice. On the day 2.
[Effects of bisphenol-A on blastocyst development and implantation].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
August 2014
Article Synopsis
- A study was conducted to assess the impact of bisphenol-A (BPA) on the development and implantation of blastocysts in pregnant mice, using various dosages of BPA (100, 300, and 600 mg/(kg·d)).
- Results indicated that high BPA concentrations (300 mg/(kg·d) and above) significantly decreased the number of implantation sites and rates, with the 600 mg/(kg·d) group showing no implantation at all.
- While BPA treatment did not notably affect overall blastocyst development rates, it decreased hatching rates and increased apoptosis (cell death) in blastocysts at higher BPA dosages, indicating potential harm to embryo health.
[Histone modifications during spermatogenesis and male infertility].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
February 2014
Many pathological phenomena of male infertility are related to epigenetic changes in male germ cells. Epigenetic regulation during spermatogenesis plays an important role in mitotic/meiotic divisions and spermiogenesis. The histones have various post-translational modifications on different amino acid residues during spermatogenesis.
View Article and Find Full Text PDF[Effects of bisphenol A on the female reproductive organs and their mechanisms].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
December 2013
Article Synopsis
- Bisphenol A (BPA) is an environmental estrogen that is widely used and can disrupt endocrine functions in female mammals.
- Prolonged exposure to BPA is linked to structural and functional changes in reproductive organs such as the ovaries, uterus, vagina, and oviducts.
- The review explores how BPA interacts with different molecular targets in the female reproductive system and examines the potential mechanisms behind these effects.
Chinese medicines (CMs) are increasingly being used for the treatment of tumors because of their unique advantages. The induction of tumor cell apoptosis is an important method of tumor treatment. Caspase-3 is a member of the caspase (cysteine aspartic proteinases) family of enzymes, which are the major inducers of apoptosis.
View Article and Find Full Text PDFPolycomb group proteins and their roles in regulating stem cell development.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
June 2012
Article Synopsis
- Polycomb group (PcG) proteins help regulate gene expression, specifically repressing genes during stem cell growth and differentiation.
- The PcG family includes two key complexes: PRC1 and PRC2, which play crucial roles in this regulation.
- The review focuses on understanding the composition, localization, recruitment, and overall functions of PcG proteins in stem cell development.
[An experimental study on injury of hippocampus neurons in rats by simulated push-pull maneuver of different degrees].
Space Med Med Eng (Beijing)
April 2004
Objective: To explore the degree of injury and phase of push-pull effect induced by different degrees of push-pull maneuver on hippocampus neurons in rats.
Method: Injury of push-pull maneuver on hippocampus neurons in rats after different degrees of push-pull maneuver were determined by general evaluation of animal model, pathologic examination and electronic microscopy.
Result: 1) General evaluation of animal model: the apoplexy index and the pathological grading increased with the increase of intensity of the push-pull maneuver.