Histone demethylase KDM2B inhibits the chondrogenic differentiation potentials of stem cells from apical papilla.

Mesenchymal stem cells (MSCs) are a reliable resource for tissue regeneration, but the molecular mechanism underlying directed differentiation remains unclear; this has restricted potential MSC applications. Histone methylation, controlled by histone methyltransferases and demethylases, may play a key role in MSCs differentiation. Previous studies determined that KDM2B can regulate the cell proliferation and osteo/dentinogenic differentiation of MSCs.

[Effect of nerve growth factor on the early phase of osseointegration around oral implants].

Objective: To observe the early bone integration of oral implants after injection of exogenous nerve growth factor (NGF) and investigate the effects of NGF on peri-implant osseointegration.

Methods: Twelve New Zealand white rabbits were used in this study to establish bi-mandible implant model. Then local injection of 1 µg NGF was given on the right side of the mandible as experimental group and normal saline only was injected on the left side as control group once a day for seven days.

[Increase of saliva nitrate and nitrite level in patients with oral candidiasis].

Objective: To observe the alterations of saliva nitrate and nitrite level in patients with oral candidiasis.

Methods: Parotid saliva and whole saliva were collected from 33 patients and 34 healthy volunteers. Concentrations of nitrate and nitrite in saliva were determined by high-performance liquid chromatography.

Effect of same-dose single or dual field irradiation on damage to miniature pig parotid glands.

Aim: To evaluate the effect of single or dual field irradiation (IR) with the same dose on damage to miniature pig parotid glands.

Methodology: Sixteen miniature pigs were divided into two IR groups (n=6) and a control group (n=4). The irradiation groups were subjected to 20 Gy X-radiation to one parotid gland using single-field or dual-field modality by linear accelerator.

[Effect of single dose irradiation to parotid gland on the structured and function changes of bilateral parotid glands in miniature pig].

Objective: To evaluate the effects of a solitary megadose protocol of ionizing radiation (IR) to parotid gland on the structured and function changes of bilateral parotid glands in miniature pig.

Methods: Fourteen minipigs were subjected to either 15 or 20 Gy to one parotid gland with a linear accelerator, while another four minipigs served as non-IR controls. Salivary flow rates and salivary chemistries were measured pre-IR, and 4 and 16 weeks post-IR.