Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents.

A series of new aryloxyacetamide derivatives 10a-s and 14a-m are designed and synthesized. Their protective activities against the glutamate-induced cell death were investigated in differentiated rat pheochromocytoma cells (PC12 cells). Most compounds exhibited neuroprotective effects, especially for 10m, 10r, 14b and 14c, which showed potential protection of PC12 cells at three doses (0.

[Fouling behavior of sodium alginate during microfiltration at various ionic compositions: XDLVO approach].

The extended Derjaguin-Laudau-Verwey-Overbeek (XDLVO) theory was utilized to quantitatively evaluate short-range interfacial interactions involved in microfiltration (MF) membrane fouling by sodium alginate (SA) at various ionic compositions. Results showed that for hydrophilic membrane surfaces, van der Waals interactions facilitated fouling, whereas acid-base interactions alleviated fouling; for hydrophobic membrane surfaces, however, van der Waals interactions mitigated fouling and acid-base interactions turned out to be favorable for fouling. Electrostatic double layer interactions contributed minimally to fouling when SA molecules came into contact with MF membrane surface.

[Efficient isolation of mesenchymal stem cells from human bone marrow by direct plating method combined with modified primary explant culture].

Human bone marrow is the major source of mesenchymal stem cells (MSC). It was reported that the standard density gradient centrifugation method was not efficient in isolating MSC and it may be caused by the existing of bone marrow particles. In previous study, a lot of MSC were obtained by culturing bone marrow particles alone combined with standard method.