Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates.

A class of iodobenzoyldiazenido-functionalized POMs (TBA) [MoO(=N=NCOAr)] (Ar = Ph--I ; Ph--I ; Ph--I ; Ph-3,4-I ; Ph-2,3,5-I (TBA = tetrabutylammonium) were prepared the refluxing reaction of -octamolybdates, DCC, and corresponding hydrazides in dry acetonitrile. Their structures were determined by Fourier-transform infrared spectroscopy, ultraviolet-visible spectra, X-ray photoelectron spectroscopy, hydrogen-1 nuclear magnetic resonance, and high-resolution mass spectrometry. Research on the biological activity of title compounds shows that , , and demonstrate potent inhibitory activity against coxsackievirus B3 and low cytotoxic activity against Hep-2 cell lines.

Biallelic XPR1 mutation associated with primary familial brain calcification presenting as paroxysmal kinesigenic dyskinesia with infantile convulsions.

Background: Mutations in the XPR1 gene are associated with primary familial brain calcifications (PFBC). All reported mutations are missense and inherited as an autosomal dominant trait. PFBC patients exhibited movement disorders, neuropsychiatric symptoms, and other associated symptoms with diverse severity, even within the same family.