Publications by authors named "Zhao-Xuan Zheng"
Alzheimer's disease (AD) is the most common cause of dementia worldwide. Due to its uncertain pathogenesis, there is currently no treatment available for AD. Increasing evidences have linked cellular senescence to AD, although the mechanism triggering cellular senescence in AD requires further exploration.
View Article and Find Full Text PDFAs a key endogenous negative regulator of ferroptosis, glutathione peroxidase 4 (GPX4) can regulate its antioxidant function through multiple post-translational modification pathways. However, the effects of the phosphorylation/dephosphorylation status of GPX4 on the regulation of inducible ferroptosis in hepatocellular carcinoma (HCC) remain unclear. To investigate the effects and molecular mechanism of GPX4 phosphorylation/dephosphorylation modification on ferroptosis in HCC cells.
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- - This study investigated the impacts of prenatal exposure to phthalates (PAEs) and polybrominated diphenyl ethers (PBDEs) on neonatal health in Guangxi, China, analyzing the serum of 267 healthy pregnant women for specific chemicals. - Key findings include that higher levels of certain phthalates (like MBP and MEHP) were linked to negative birth outcomes such as lower birth weight and increased risk for premature births, while one PBDE (BDE28) showed opposite effects concerning weight. - Additionally, interactions between different chemicals affected the risk of neonatal jaundice, with notable differences found in response based on ethnicity and sex, indicating that prenatal chemical exposures can harm neonatal health in complex and varied ways.