Publications by authors named "Zhao-Wei Zhu"
Peripheral nerve injury (PNI) involving the loss of sensory and movement functions is challenging to repair. Although the gold standard of PNI repair is still the use of autologous nerve grafts, the destruction of the donor side is inevitable. In the present study, peripheral nerve tissueoids (PNTs) composed of a Schwann cell (SC)-based neurotrophin-3 (NT-3) delivery system and a decellularized optic nerve (DON) with naturally oriented channels were engineered to investigate the mechanism of PNTs in nerve regeneration.
View Article and Find Full Text PDFObjective: To investigate the expression and significance of GDF3 in testicular cancer through bioinformatics analysis.
Methods: Using the TCGA and GTEx databases, differential expression analysis and pan-cancer analysis were performed to identify the target gene GDF3, and the clinical relevance of GDF3 in testicular cancer was analyzed using the UALCAN database. Based on the R packages "org.
Article Synopsis
- The study examines the relationship between low-density lipoprotein cholesterol (LDL-C) levels after coronary artery bypass grafting (CABG) and long-term health outcomes, finding that only 14.9% of patients met the LDL-C target of <1.40 mmol/L one year post-surgery.
- Among the 2072 patients analyzed, 25% experienced major adverse cardiovascular and cerebrovascular events (MACCEs) over an average follow-up of 4.2 years, with higher LDL-C levels significantly linked to an increased risk for these events.
- The findings suggest a need for better lipid management strategies post-CABG to potentially reduce long-term cardiovascular risks, prompting proposals for further studies to confirm these results
Background: Identify immune-related gene pairs (IRGPs) signature related to the prognosis and immunotherapeutic efficiency for bladder cancer (BLCA) patients.
Materials And Methods: One RNA-seq dataset (The Cancer Genome Atlas Program) and two microarray datasets (GSE13507 and GSE31684) were included in this study. We defined these cohorts as training set to construct IRGPs and one immunotherapy microarray dataset as validation set.
Objective: To investigate the association of the grades of histologic prostatic inflammation (HPI) with prostate cancer in biopsy specimens for male patients with total serum PSA (tPSA) of 4－10 μg/L.
Methods: We performed prostate biopsy for 200 patients with tPSA of 4－10 μg/L from January 2015 to December 2017. We determined the location, extent and intensity of HPI and analyzed the correlation of the grades of HPI with the risk of prostate cancer.
Ventricular pseudoaneurysm (PSA) is a rare, yet life-threatening complication of myocardial infarction, cardiac surgery, and transcatheter valve replacement. Although conventional surgery is the preferred treatment strategy, transcatheter closure has emerged as an effective alternative in selected candidates. In this report, we describe successful transcatheter closure of two unique cases of ventricular pseudoaneurysm (PSA): first, a complex post-myocardial infarction left ventricular PSA (LVPSA) with multi-communications, and second, a case of post-traumatic right ventricular PSA (RVPSA) following blunt chest injury caused by domestic violence.
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- The study explores the relationship between metabolic syndrome and bladder cancer, aiming to provide more comprehensive insights beyond previous studies focused on specific components.
- Researchers analyzed 95 studies involving nearly 98 million subjects, finding that metabolic syndrome and its components, particularly diabetes and excessive body weight, significantly increased the risk of bladder cancer and negatively impacted survival rates.
- Results highlighted the need for more research to clarify the effects of overall metabolic syndrome, hypertension, and dyslipidemia on bladder cancer risk and outcomes, as some associations still lack sufficient data.
An aging-induced decrease in Schwann cell viability can affect regeneration following peripheral nerve injury in mammals. It is therefore necessary to investigate possible age-related changes in gene expression that may affect the biological function of peripheral nerves. Ten 1-week-old and ten 12-month-old healthy male Sprague-Dawley rats were divided into young (1 week old) and adult (12 months old) groups according to their ages.
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- This study investigates the clinical outcomes of treating small side branches during main vessel stenting in coronary artery disease patients, focusing on whether treating compromised side branches (SBT) is beneficial compared to not treating them (NSBT).
- A total of 119 patients with small side branches were analyzed, revealing that SBT procedures took significantly longer and had more complications than NSBT, but both groups had similar rates of major adverse cardiovascular events (MACE) and improvements in heart function classifications.
- The findings suggest that not treating compromised small side branches does not increase the risk of MACE or negatively affect heart function, indicating that less aggressive management may be sufficient in these cases.
The experimental design evaluated histological, mechanical, and biological properties of allogeneic decellularized nerves after cryopreservation in a multi-angle, multi-directional manner to provide evidence for long-term preservation. Acellular nerve allografts from human and rats were cryopreserved in a cryoprotectant (10% fetal bovine serum, 10% dimethyl sulfoxide, and 5% sucrose in RPMI1640 medium) at -80°C for 1 year, followed by thawing at 40°C or 37°C for 8 minutes. The breaking force of acellular nerve allografts was measured using a tensile test.
View Article and Find Full Text PDFSensory function is the most significant criterion when evaluating the prognosis of replanted fingers. Current clinical research has focused on surgical techniques and indications for finger replantation; however, few studies have focused on recovery of finger sensory function after replantation. This study retrospectively assessed data of eight patients who had undergone nine Zone I replantations of the fingertips in the First Affiliated Hospital of Sun Yat-sen University of China from July 2014 to January 2016.
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- The study explored the role of serum high mobility group box-1 (HMGB1) levels in diagnosing and monitoring patients with pulmonary arterial hypertension (PAH) due to congenital heart disease (PAH-CHD).
- HMGB1 levels were significantly higher in PAH patients compared to those without PAH and healthy controls, showing a strong correlation with measures of pulmonary arterial pressure and resistance.
- The findings suggest that HMGB1 could be a useful biomarker for detecting PAH severity and assessing treatment response, especially after sildenafil therapy.
Objective: The aim of this study was to determine the changes and underlying mechanisms of erectile organ structure and function in castrated rats. In addition, the regulatory effects of an androgen on autophagy and apoptosis in corpus cavernosum smooth muscle cells (CCSMCs), especially the regulatory effect of androgen on the BECN 1-Bcl-2 interaction, were investigated.
Methods: Male Sprague-Dawley rats were divided into three groups (30/group): control group, castration group, and castration with testosterone supplementation group.
Aims: In this study, we aim to summarise our experience with techniques used for the transcatheter retrieval of embolised devices.
Methods: We retrospectively reviewed the transcatheter retrieval of embolised devices in seven patients who underwent an attempted transcatheter closure of perimembranous ventricular septal defects (PMVSDs) between October 2002 and October 2013. The incidence, the main causes for the device's embolisation, and the techniques for transcatheter retrieval of the embolised device are discussed.
Objective: To address the molecular mechanisms that the vitamin D receptor (VDR) in the kidney might contribute to decreased renal calcium reabsorption in idiopathic hypercalciuria using genetic hypercalciuric stone-forming (GHS) rats.
Methods: We silenced the VDR gene in the GHS and normal control (NC) rat kidney in vivo using adenovirus vector-delivered microRNA targeting VDR through renal venous transduction. On days 3-21 after injection with adenovirus, the expression levels of the VDR, calcium-sensing receptor, and epithelial calcium transporters in the kidney were detected.
Background And Objective: p53 gene is one of cancer suppressor genes and its mutation and deletion induces almost all human cancers. This study was to evaluate the clinical efficacy and toxicity of recombinant human Ad-p53 injection (rAd-p53) combined with cisplatin in treatment of malignant pleural effusion induced by lung cancer.
Methods: A total of 35 cases of malignant pleural effusion were randomly divided into the combined group (n=17) and the single-agent group (n=18).