The impact of the length of proximal margin on the prognosis in adenocarcinoma of gastroesophageal junction: A real-world study and strategies.

Background: The optimal proximal margin (PM) length for Siewert II/III adenocarcinoma of the esophagogastric junction (AEJ) remains unclear. This study aimed to determine the optimal PM length using an abdominal approach to guide surgical decision-making.

Methods: A prospective study analyzed 304 consecutive patients diagnosed with Siewert II/III AEJ between January 2019 and December 2021.

Two chromosome-level genome assemblies of Rhodiola shed new light on genome evolution in rapid radiation and evolution of the biosynthetic pathway of salidroside.

Rhodiola L. is a genus that has undergone rapid radiation in the mid-Miocene and may represent a typic case of adaptive radiation. Many species of Rhodiola have also been widely used as an important adaptogen in traditional medicines for centuries.

Group V Chitin Deacetylases Influence the Structure and Composition of the Midgut of Beet Armyworm, .

Chitin deacetylase (CDA) can accelerate the conversion of chitin to chitosan, influencing the mechanical properties and permeability of the cuticle structures and the peritrophic membrane (PM) in insects. Putative Group V CDAs SeCDA6/7/8/9 (SeCDAs) were identified and characterized from beet armyworm larvae. The cDNAs of contained open reading frames of 1164 bp, 1137 bp, 1158 bp and 1152 bp, respectively.

Connexin43 hemichannels contribute to working memory and excitatory synaptic transmission of pyramidal neurons in the prefrontal cortex of rats.

The gap junction is essential for the communication between astrocytes and neurons by various connexins. Connexin43 hemichannels (Cx43 HCs), one of important subunits of gap junction protein, is highly expressed in astrocytes. It has been demonstrated that Cx43 HCs is involved in synaptic plasticity and learning and memory.

RNA interference-mediated functional characterization of Group I chitin deacetylases in Holotrichia parallela Motschulsky.

Chitin deacetylases (CDAs, EC 3.5.1.

Real-world data on the effectiveness and safety of interferon-alpha-2a intralesional injection for the treatment of focally recalcitrant mycosis fungoides.

Background: Focally recalcitrant mycosis fungoides (MF) is challenging to treat. Despite interferon (IFN)-α intralesional injection having been tested in randomized controlled trials for the treatment of patch or early plaque lesions of MF, no real-world data regarding this therapy for focally recalcitrant MF has been reported. This study aimed to evaluate the effectiveness and safety of IFN-α-2a intralesional injection in focally recalcitrant MF.

Efficacy of cognitive behavioural therapy with medication for patients with obsessive-compulsive disorder: A multicentre randomised controlled trial in China.

Background: Meta-analyses support the efficacy of cognitive behavioural therapy (CBT) for obsessive-compulsive disorder (OCD) in Western cultures. However, there are no adequately powered multicentre studies in China. This study aimed to compare the effectiveness of treatment with CBT combined with medication and medication alone in OCD patients in China.

Survey on the use of mental health services and help-seeking behaviors in a community population in Northwestern China.

There is little research into the patterns of mental health services use, related factors, and barriers in help-seeking behaviors among the community population in northwestern China. We conducted a community-based survey among the general population in Xi'an City with the stratified two-stage systematic selection scheme using the World Health Organization Composite International Diagnostic Interview version 3.0 computer-assisted personal interview (CIDI-CAPI 3.

β-Aescin shows potent antiproliferative activity in osteosarcoma cells by inducing autophagy, ROS generation and mitochondrial membrane potential loss.

Purpose: Osteosarcoma is one of the frequent bone tumor affecting mainly children and is associated with considerable mortality. The limited availability of anticancer drugs and less efficacious treatment options have led to poor survival rates of patients with osteosarcoma. Therefore, there is need to look for more viable treatment options and against this backdrop, natural products may prove handy.

A Cross-sectional Survey of Disability Attributed to Mental Disorders and Service Use in China.

Background: Mental disorders are strongly associated with disabilities. National survey on disability could provide a reliable basis for policymaking in care and rehabilitation of disabled persons. This study aimed to describe the disability prevalence rates attributed to mental disorders, their distribution by sociodemographic factors, and utilizations of service.

Distribution and Risk Factors of Disability Attributed to Personality Disorders: A National Cross-sectional Survey in China.

Background: Personality disorders can lead to some disability. However, little is known about the disability prevalence and function impairments. This study aimed to describe the disability prevalence attributed to personality disorders, its distribution, impairments of daily activities and social functions, and risk factors in China.

Validity of Chinese Version of the Composite International Diagnostic Interview-3.0 in Psychiatric Settings.

Background: The Composite International Diagnostic Interview-3.0 (CIDI-3.0) is a fully structured lay-administered diagnostic interview for the assessment of mental disorders according to ICD-10 and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria.

[Descriptive epidemiological study on disabilities attributed to non-dementia organic mental disorder in China].

Objective: To describe the prevalence rates of disabilities attributed to non-dementia organic mental disorder and their demographic and regional distributions in China for supporting policy maker to prevent mental disabilities.

Methods: Using the data from the second China National Survey on Disability, the prevalence rates were statistically analysed.

Results: There were 1 200 people with non-dementia organic mental disabilities in 2 526 145 respondents, the point prevalence rate of disabilities attributed to non-dementia organic mental disorder was 0.

Psychological symptoms and associated risk factors in Chinese freshmen: a three-year follow-up study.

Background: The first year of attending university induces a stressful experience for many college students. The experience exposes these students to challenging circumstances and raises expectations, which consequently increases the risk of psychiatric disorders and may exacerbate pre-existing problems. This study was designed to explore the risk factors of psychological symptoms among freshmen in China.

Poststroke depression and risk of recurrent stroke at 1 year in a Chinese cohort study.

Background: Studies show that poststroke depression (PSD) increases mortality risk at 1 year. However, whether PSD increases the risk of recurrent stroke at 1 year remains unclear. This study was to investigate whether PSD at 2 weeks following a stroke could increase risk of recurrent stroke at 1 year.

Time course of depression and one-year prognosis of patients with stroke in mainland China.

Aims: To investigate the incidence of depression at different time points within the first year after stroke in mainland China and to identify risk factors related to a poor 1-year prognosis in stroke patients.

Methods: Subjects with acute cerebrovascular diseases were recruited and enrolled from 56 hospitals in mainland China between April 2008 and April 2010. Demographic data, previous disease history, and clinical data were collected.

Individual and societal impact on earnings associated with serious mental illness in metropolitan China.

To evaluate individual-level and societal-level losses of income associated with serious mental illness in metropolitan China, a multi-stage probability survey was administered to adults aged 18-70 years in Beijing and Shanghai. We used data to estimate individual-level expected earnings from a model that included information about the respondents' education level, marital status, age, and gender. Expected earnings were compared to observed earnings among respondents with mental illness and serious disability.

Impaired role functioning and treatment rates for mental disorders and chronic physical disorders in metropolitan China.

Objectives: To compare impairments in role functioning and treatment rate of mental disorders and chronic physical disorders in the general population of metropolitan China.

Method: Face-to-face household interviews of 5201 people aged 18 to 70 years in Beijing and Shanghai were conducted from November 2001 to February 2002, using a multistage household probability sampling method. The World Mental Health version of the Composite International Diagnostic Interview (WMH-CIDI) was used for assessing sociodemographic characteristics, diagnoses, and treatment.

Associations of cohort and socio-demographic correlates with transitions from alcohol use to disorders and remission in metropolitan China.

Aims: To examine socio-demographic associations of transitions from alcohol use to disorders and of remission from disorders in metropolitan China.

Design And Setting: Face-to-face interviewing by trained lay-interviewers on a multi-staged, clustered sample from the general population of Beijing and Shanghai, China.

Participants: A total of 5201 adults aged 18-70 years and with household registration.

Arthritis and physical-mental comorbidity in metropolitan China.

Background: This study estimates psychiatric and physical comorbidity among people reporting arthritis and related role impairment in metropolitan China.

Methods: Data were derived from a large-scale and representative household survey of adult respondents in Beijing and Shanghai. Arthritis and other chronic physical conditions were assessed by self-report.

Lifetime prevalence and inter-cohort variation in DSM-IV disorders in metropolitan China.

Background: This is the first study to examine variation across cohorts in lifetime risk of DSM-IV mental disorders in metropolitan China.

Method: Face-to-face household interviews of 2633 adults in Beijing and 2568 adults in Shanghai were conducted from November 2001 to February 2002 using a multi-stage household probability sampling method. The Chinese World Mental Health (WMH) Survey Initiative version of the WHO Composite International Diagnostic Interview (WMH-CIDI) was used for assessment.

[Economic evaluation of "early detection and treatment of esophageal cancer"].

Background & Objective: In China, esophageal cancer is the forth death cause of malignant cancers. The survival rate of esophageal cancer patients is less than 10%. Early detection and treatment of esophageal cancer is essential to improve the survival rate of these patients.

Twelve-month prevalence, severity, and unmet need for treatment of mental disorders in metropolitan China.

Background: Psychiatric epidemiological surveys in China have repeatedly found much lower prevalence estimates than in most other parts of the world.

Method: Face-to-face household interviews of 5201 subjects (2633 in Beijing and 2568 in Shanghai respectively) were conducted from November 2001 to February 2002 using a multistage household probability sampling method. A Chinese version of the World Health Organization Composite International Diagnostic Interview (CIDI) was used for assessment.

[Study on the psychosocial status and related factors in three universities during severe acute respiratory syndrome epidemic in Beijing].

Objective: To investigate the psychosocial status and related factors among university students during severe acute respiratory syndrome (SARS) epidemic in Beijing.

Methods: By means of stratified cluster sampling, symptom checklist-90 (SCL-90) and questionnaire on general information were applied among 6800 students in three universities in Beijing.

Results: There were 6280 valid questionnaires gathered.