Targeted bile acid profiles reveal the liver injury amelioration of Da-Chai-Hu decoction against ANIT- and BDL-induced cholestasis.

Multiple types of liver diseases, particularly cholestatic liver diseases (CSLDs) and biliary diseases, can disturb bile acid (BA) secretion; however, BA accumulation is currently seen as an important incentive of various types of liver diseases' progression. Da-Chai-Hu decoction (DCHD) has long been used for treating cholestatic liver diseases; however, the exact mechanisms remain unclear. Currently, our study indicates that the liver damage and cholestasis status of the α-naphthylisothiocyanate (ANIT)-induced intrahepatic cholestasis and bile duct ligation (BDL)-induced extrahepatic cholestasis, following DCHD treatment, were improved; the changes of BA metabolism post-DCHD treatment were investigated by targeted metabolomics profiling by UPLC-MS/MS.

Phytoextraction by harvesting dead leaves: cadmium accumulation associated with the leaf senescence in Festuca arundinacea Schreb.

Phytoextraction strategy by harvesting dead leaves provides continuous phytoremediation and a great saving in disposal cost of hazardous plant residues. This strategy is entirely dependent upon the amount of cadmium (Cd) accumulated in dead leaves. However, it is unknown that whether the leaf Cd accumulation is associated with its senescence and how to regulate its Cd accumulation.

Activation and blockade of 5-HT receptors in the dorsal hippocampus enhance working and hippocampus-dependent memories in the unilateral 6-hydroxydopamine lesioned rats.

Cognitive dysfunction is a common symptom in Parkinson's disease (PD). Serotonin4 (5-HT) receptors are richly expressed in the dorsal hippocampus (dHIPP) and play an important role in cognitive activities. However, the mechanism underlying the role of dHIPP 5-HT receptors in PD-related cognitive dysfunction remains unclear.

Activation and blockade of dorsal hippocampal serotonin4 receptors produce antidepressant effects in the hemiparkinsonian rats.

Depression is a common non-motor symptom in Parkinson's disease (PD). Although serotonin4 (5-HT) receptors and the dorsal hippocampus (dHIP) are regarded to be involved in the depression, the mechanism underlying the effects of 5-HT receptors in the dHIP on PD-related depression should be further investigated. In the present study, unilateral 6-hydroxydopamine lesions of the medial forebrain bundle (MFB) increased the expressions of 5-HT receptors and its co-localization with glutamate neurons in the CA1, CA3 and dentate gyrus.

Zinc promotes cadmium leaf excretion and translocation in tall fescue (Festuca arundinacea).

Phytoexcretion is a novel strategy to remediate cadmium (Cd) pollution by leaf excretion in tall fescue (Festuca arundinacea), which involves the processes of Cd leaf excretion, root-to-leaf translocation, and root uptake. A hydroponic experiment was designed to investigate a series of 11 zinc (Zn) concentrations on Cd leaf excretion in tall fescue under 75 μM Cd stress. The results showed that the promotions of Zn on Cd leaf excretion, root-to-leaf translocation, and leaf accumulation were concentration-dependent in tall fescue.

Improvement cues of lesion absorption using the adjuvant therapy of traditional Chinese medicine Qinbudan tablet for retreatment pulmonary tuberculosis with standard anti-tuberculosis regimen.

Background: China is the second highest pulmonary tuberculosis (PTB) burden country worldwide. However, retreatment of PTB has often developed resistance to at least one of the four first-line anti-TB drugs. The cure rate (approximately 50.

Young leaf protection from cadmium accumulation and regulation of nitrilotriacetic acid in tall fescue (Festuca arundinacea) and Kentucky bluegrass (Poa pratensis).

Phytoextraction efficiency of cadmium (Cd) contaminated soil mainly depended upon the mechanism of plants in absorption, translocation, distribution, and detoxification of Cd. A pot experiment was designed to investigate Cd distribution and accumulation among the different leaves of tall fescue (Festuca arundinacea) and Kentucky bluegrass (Poa pratensis) and its regulation by Nitrilotriacetic acid (NTA), a biodegradable chelating agent. The results showed that Cd concentrations in the senescent and dead leaves were 3.

Differential effects of citric acid on cadmium uptake and accumulation between tall fescue and Kentucky bluegrass.

Organic acids play an important role in cadmium availability, uptake, translocation, and detoxification. A sand culture experiment was designed to investigate the effects of citric acid on Cd uptake, translocation, and accumulation in tall fescue and Kentucky bluegrass. The results showed that two grass species presented different Cd chemical forms, organic acid components and amount in roots.

Differential Cadmium Distribution and Translocation in Roots and Shoots Related to Hyper-Tolerance between Tall Fescue and Kentucky Bluegrass.

Phytoremediation efficiency mainly depends upon mechanisms in the uptake and translocation of soil contaminants. Cadmium (Cd) distribution and translocation in roots and shoots of tall fescue () and Kentucky bluegrass () were observed using fluorescence spectroscopy with a laser confocal scanning microscope. No difference in root Cd accumulations was detected between these two turfgrass species.

[Protective effects of da chai hu granules (DCHKL) against alloxan (AXN)-induced rat pancreatic islets damage].

The protective effects of Da Chai Hu Granules (DCHKL) on islet cells which were incubated with 4 mmol x L(-1) alloxan (AXN) were studied. The viability of islet cells were measured with MTT. Insulin released into medium and in islets was detected by radioimmunoassay.