Publications by authors named "Zhao-Lin Zeng"

The global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) has risen sharply. This condition is strongly associated with the risk of cardiovascular disease (CVD), but how MAFLD affects the development and progression of CVD, particularly concerning vascular calcification, remains unclear. Herein, extracellular vesicles (EVs) are identified from steatotic hepatocytes as a trigger that accelerated the progression of both vascular intimal and medial calcification.

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  • - Vascular calcification is a serious health issue linked to high rates of cardiovascular problems, and the role of antibiotics in affecting this condition through gut microbiota disruption is still uncertain.
  • - In studies using antibiotic treatments, researchers found that antibiotics worsened vascular calcification in mice by decreasing certain beneficial gut bacteria and short-chain fatty acids (SCFAs) in the body.
  • - Adding acetate was shown to help reduce calcium deposits in blood vessels and prevent the transformation of vascular smooth muscle cells into bone-like cells, with its effects possibly linked to specific metabolic processes involving glutathione.
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  • Akkermansia muciniphila (A. muciniphila) is an important anaerobic bacterium that inhabits the mucus layer of the gut in humans and animals, playing a significant role in metabolism, inflammation, and cancer immunotherapy.
  • Recent research has highlighted a connection between A. muciniphila and aging, as well as aging-related diseases (ARDs) such as vascular degeneration, neurodegenerative diseases, and type 2 diabetes, shifting focus from just correlation to exploring causation.
  • The paper reviews current findings on A. muciniphila's association with ARDs and discusses its potential mechanisms of action, while also suggesting future research directions.
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Accumulating evidence suggests that the therapeutic role of mesenchymal stem cells (MSCs) in bone diseases is closely related to paracrine-generated extracellular vesicles (EVs). MSC-derived EVs (MSC-EVs) carry proteins, nucleic acids, and lipids to the extracellular space and affect the bone microenvironment. They have similar biological functions to MSCs, such as the ability to repair organ and tissue damage.

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  • Ant venom can cause serious allergic reactions, primarily through biologically active components that may lead to symptoms like anaphylaxis, eosinophil recruitment, and Th2 cytokine production.* -
  • A case involving a 70-year-old man illustrates severe reactions from ant bites, leading to hospitalization due to symptoms like pustules, fever, and psychological disturbances, necessitating extensive treatment.* -
  • After appropriate medical intervention, including corticosteroids and antihistamines, the patient improved significantly, highlighting the potential dangers of ant stings and the need for prompt treatment.*
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Background: Clinically relevant postoperative pancreatic fistula (CR-POPF) is the most common and severe complication after pancreaticoduodenectomy (PD). Despite the development of numerous anastomotic surgical techniques to minimize CR-POPF, more than 30% of patients who undergo PD develop CR-POPF. Herein, we propose a novel pancreaticojejunostomy (PJ) technique and evaluate its efficacy and safety compared to traditional PJ.

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Colorectal cancer (CRC) is one of the most common digestive tract tumors worldwide. Catalpol exerts inhibitory effects on the progression of several cancer types by regulating microRNAs (miRs). However, the precise role and carcinostatic mechanism of catalpol on CRC cells are poorly understood which limits the application of catalpol treatment.

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Induced pluripotent stem (iPS) cells can differentiate into nearly all types of cells. In contrast to embryonic stem cells, iPS cells are not subject to immune rejection because they are derived from a patient's own cells without ethical concerns. These cells can be used in regenerative medical techniques, stem cell therapy, disease modelling and drug discovery investigations.

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High concentrations of plasma lipoprotein(a) [Lp(a)] have been inferred to be an independent risk factor for cardiovascular and cerebrovascular diseases, such as coronary artery diseases, restenosis, and stroke. Apolipoprotein(a) [apo(a)] is one of the most important components of Lp(a) and contributes greatly to the increased concentration of plasma Lp(a). As a critical positive transacting factor of apo(a) gene, Ets1 has been proven as a target gene of several miRNAs, such as miR-193b, miR-125b-5p, miR-200b, miR-1, and miR-499.

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Objective: The aim of the present study was to validate the Grandway MD2301 digital automatic blood pressure monitor according to the European Society of Hypertension International Protocol (ESH-IP) revision 2010.

Methods: The ESH-IP revision 2010 for the validation of blood pressure-measuring devices in adults was followed precisely. Systolic and diastolic blood pressure (SBP and DBP, respectively) were measured sequentially in 33 adult patients and compared with a standard mercury sphygmomanometer (two observers).

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Background: In the last decade, studies in hepatocellular carcinoma (HCC) demonstrate dysregulation of miRNAs expression. For instance, miR-650 has been implicated in gastric and colorectal cancer tumorigenicity; however, the role of miR-650 remains unknown in HCC.

Methods: In this study, we performed a comprehensive analysis to examine the miR-650 expression level in 248 HCC and 120 paracarcinomatous liver (PCL) tissues.

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Objective: Reviewing the studies on the chemical components and medicinal value.

Method: Philological method.

Result: Saffron is a conventional effective medicine in improving blood circulation and curing the bruise.

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