Publications by authors named "Zhao-Kun Yin"

Article Synopsis
  • Thirteen new diterpenoid quinones were extracted from the dried roots of the plant Salvia miltiorrhiza, and their structures were identified using advanced analytical methods like NMR and X-ray diffraction.* -
  • The absolute configurations of these compounds were confirmed through techniques such as circular dichroism spectroscopy and optical rotation.* -
  • Among these compounds, salviadionether and other derivatives demonstrated significant anti-cancer properties, particularly salviadionether, which inhibited the growth of specific tumor cells, and salvianone ester A, which was strongly cytotoxic to tumor-repopulating cells.*
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Three new compounds named tanshinoic acid A (), tanshinoic acid B (), and tanshinoic acid C () were isolated from the rhizomes of , together with two known compounds methyl salvianolate A () and methyl salvianolate C (). Their structures were determined on the basis of spectroscopic data (UV, IR, HRESIMS, 1 D and 2 D NMR). The assay indicated that and could improve the survived rate of cells on oxygen glucose deprivation (OGD) induced neurons damage model and glutamate-induced neurons damage model at a concentration of 10 M.

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One new tanshinone derivative, which possesses an unusual 6/6/5/6 fused-ring skeleton system (1), together with four new five-membered lactone benzohexa-membered ring compounds (2, 3, 4A and 4B), and three new carboxyl substituted 5,5-spiroketal compounds (5-7), were isolated from the dried rhizomes of . The structures of these compounds were determined by multiple spectral analyses (UV, IR, NMR, and HR-ESI-MS). In addition, the absolute configurations were established by X-ray diffraction experiments, calculated and experimental circular dichroism spectra.

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Two new naturally occurring products named salviamine G (1) and 4-methyl-9-(ethoxycarbonyl)-8-naphthoic acid (2) were isolated from the rhizomes of . Their structures were elucidated using spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). Compounds and were screened for their inhibitory activity against HSV-1 and influenza A (H3N2) using acyclovir (ACV, IC = 0.

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