Publications by authors named "Zhao-Hong Huang"
Acute pancreatitis (AP) is the acute inflammation of the pancreas. The morbidity of AP has increased in recent years. Certain patients eventually develop severe AP (SAP), which rapidly progresses to multiple organ dysfunction; the incidence of this occurring in patients with AP is 20-30%.
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- CEACAM6 is a member of the carcino-embryonic antigen family and has been linked to cancer development, particularly pancreatic carcinoma, where its expression is notably higher in cancerous tissue compared to non-cancerous tissue.
- The study found a significant correlation between CEACAM6 levels and clinical parameters, indicating that higher levels were associated with advanced clinical stages and lymph node metastasis.
- Experimental manipulation of CEACAM6 using siRNA and overexpression techniques in pancreatic cancer cell lines demonstrated that it regulates cell proliferation through the cyclin D1/CDK4 pathway, highlighting its potential as a target for new cancer diagnostics and treatments.