Examining the dietary contributions of lipids to pancreatic cancer burden (1990-2021): incidence trends and future projections.

Background: Pancreatic cancer (PC) ranks sixth globally among cancer deaths, imposing a significant burden on healthcare systems worldwide. Although diet is known to be a major risk factor, Although diet is a well-established risk factor for PC, the precise dietary components linked to the disease remain inconclusive, with studies showing varying results across different populations and regions. This study addresses this gap through a comprehensive analysis of PC incidence trends from 1990 to 2021, with a specific focus on associations with age, dietary patterns, and socio-demographic determinants.

Condition-Controlled Divergent Selective Synthesis of ()--Vinyl and -Allenyl Benzimidazoles by Pd- or Bi-Catalyzed Direct -Alkenylation Reactions.

We have developed a condition-controlled divergent synthesis of ()--vinyl and -allenyl benzimidazoles from 1,1,3-triphenylprop-2-yn-1-ols and benzimidazoles through Pd- or Bi-catalyzed -alkenylation reactions involving nucleophilic attack and C-C bond cleavage processes. The desired two different kinds of products can be conveniently and selectively synthesized by using this strategy, which features stereospecific synthesis, good functional group tolerance, a broad substrate scope, and high efficiency. The strategy provides significant advantages for the synthesis of biologically and pharmaceutically active imidazoheterocycles.

Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization.

The COVID-19 pandemic has significantly impacted the quality of life (QoL) of individuals in China, affecting both their physical and mental well-being. This study aims to comprehensively analyze the factors influencing QoL in China during the pandemic. In 2022, we collected data using a self-developed questionnaire (dataset 2) and obtained dataset 1 from the 2021 China General Social Survey (CGSS).

Effects of gut microbiota and metabolites on pancreatitis: a 2-sample Mendelian randomization study.

Background: Acute pancreatitis (AP) and chronic pancreatitis (CP) have high incidences and poor prognoses. The early screening of at-risk populations still awaits further study. The limitation was mainly based on observational studies, with limited sample size and the presence of confounding factors.

Mechanical behavior and waterproof performance of longitudinal section of tunnel segment joint gasket.

In the construction stage, due to construction errors and longitudinal differential settlement during tunnel operation, the amount of dislocation and opening at the segment joint increases, increasing the likelihood of water leakage. Therefore, it is necessary to conduct an in-depth study on the influence of the amount of dislocation and opening at the segment joints on the contact stress of the longitudinal section. Firstly, through theoretical analysis, this paper deduces that the waterproof performance of the gasket depends not only on its own contact area, linear compression stiffness, and Poisson's ratio but also on the height of the segment joint specimen and the amount of joint opening caused by the sinking offset angle.

Still water run deep: Therapeutic TP effect of ucMSC-Ex via regulating mTOR to enhance autophagy.

Our previous study confirmed that umbilical cord mesenchymal stem cells-exosomes (ucMSC-Ex) inhibit apoptosis of pancreatic acinar cells to exert protective effects. However, the relationship between apoptosis and autophagy in traumatic pancreatitis (TP) has rarely been reported. We dissected the transcriptomics after pancreatic trauma and ucMSC-Ex therapy by high-throughput sequencing.

Salivary Proteome and Intact -Glycopeptides Analysis Reveal Specific Signatures in Periodontitis.

Periodontitis is a prevalent oral inflammatory disease that can result in tooth loss and is closely linked to type 2 diabetes (T2D). In this study, we analyzed the salivary proteome and intact -glycopeptides (IGPs) of individuals with mild-moderate, severe, aggressive periodontitis, and periodontitis with T2D, including those treated with antidiabetic drugs, to identify specific signatures associated with the disease. Our results revealed that salivary proteins and glycoproteins were altered in all periodontitis groups (PRIDE ID: 1-20230612-72345), with fucose- and sialic acid-containing -glycans showing the greatest increase.

Efficacy and safety of different anti-osteoporotic drugs for the spinal fusion surgery: A network meta-analysis.

Background: Administering anti-osteoporotic agents to patients perioperatively is a widely accepted approach for improving bone fusion rates and reducing the risk of complications. The best anti-osteoporotic agents for spinal fusion surgery remain unclear.

Aim: To investigate the efficacy and safety of different anti-osteoporotic agents in spinal fusion surgery network meta-analysis.

Serum uric acid is independently associated with hypertension in patients with polymyositis and dermatomyositis.

Serum uric acid (UA), as an antioxidant, has been associated with hypertension in the general population. Hypertension is highly prevalent in patients with polymyositis and dermatomyositis (PM/DM). Owning elevated levels of reactive oxygen species, patients with PM/DM have lower concentrations of UA in comparison with healthy people.

Evaluation indices of the temperature difference of subgrade and the optimization of mitigation measures in cold regions.

With the construction and operation of railways in cold regions, the asymmetric deformation of subgrades due to the difference in the transverse ground temperature has become a prominent issue. A comprehensive evaluation of the transverse ground temperature difference and investigation of the corresponding mitigation measures should be conducted to avoid or minimize the damage resulting from this difference, thereby improving subgrade stability and reducing deformation. In this study, the time history variations in the homogeneity and symmetry indices of the ground temperature at typical instances that reflect the spatial and temporal changes in the temperature difference of the subgrade were proposed as evaluation indices.

The future of robotic pancreaticoduodenal surgery: a bibliometric analysis.

Objectives: Robotic pancreaticoduodenectomy (RPD) has garnered significant research attention in the last decade. However, no bibliometric studies have been conducted on this field yet. Therefore, the aim of this study is to provide an up-to-date analysis of the current state of research, as well as future trends and hotspots in RPD, through a bibliometric analysis.

Establishment of a multifunctional impact system and a study of a pancreatic trauma model in rats based on controlling the injury area.

Background: At present, basic scientific research on pancreatic trauma is rare due to the lack of ideal animal models and modeling equipment for pancreatic trauma. Therefore, we intend to develop a multifunctional impact system with simple operation, diverse impact and accurate measurement and to establish a rat pancreatic trauma model based on injury area control by using the system.

Methods: The impactor was designed based on the convenience of the impact energy acquisition, the diversity of the impact operation, and the precision of the impact strength parameter measurement by the team.

Effect of comprehensive nursing methods in postoperative ICU of children with CHD.

To explore effect of comprehensive nursing in postoperative ICU of children with CHD. The subjects were 50 cases of children with CHD treated in our hospital: 25 cases in the control group: routine nursing, and 25 cases in the observation group: comprehensive nursing intervention. The effective rate of 92.

Impact of age on short-term outcomes after pancreaticoduodenectomy: A retrospective case-control study of 260 patients.

Background: Although the increase of perioperative complications in the elderly undergoing pancreaticoduodenectomy (PD) surgery has been recognized, the definition of the "old patient" of PD in the studies is different and there is no accepted cut-off value at present.

Methods: 279 consecutive patients who have undergone PD in our center between January 2012 and May 2020 were analyzed. Demographic features, clinical-pathological data and short-term outcomes were collected.

Removing the stumbling block of exosome applications in clinical and translational medicine: expand production and improve accuracy.

Although the clinical application and transformation of exosomes are still in the exploration stage, the prospects are promising and have a profound impact on the future transformation medicine of exosomes. However, due to the limitation of production and poor targeting ability of exosomes, the extensive and rich biological functions of exosomes are restricted, and the potential of clinical transformation is limited. The current research is committed to solving the above problems and expanding the clinical application value, but it lacks an extensive, multi-angle, and comprehensive systematic summary and prospect.

Ferroptosis in pancreatic diseases: potential opportunities and challenges that require attention.

The pancreas is an abdominal organ with both endocrine and exocrine functions, and patients with pancreatic diseases suffer tremendously. The regulated cell death of various cells in the pancreas is thought to play a key role in disease development. As one of the newly discovered regulated cell death modalities, ferroptosis has the potential for therapeutic applications in the study of multiple diseases.

Multi-level integrative analysis of the roles of lncRNAs and differential mRNAs in the progression of chronic pancreatitis to pancreatic ductal adenocarcinoma.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors and approximately 5% of patients with chronic pancreatitis (CP) inevitably develop PDAC. This study aims explore the key gene regulation involved in the progression of CP to PDAC, with a particular emphasis on the function of lncRNAs.

Results: A total of 103 pancreatic tissue samples collected from 11 to 92 patients with CP and PDAC, respectively, were included in this study.

The visceral pancreatic neck anterior distance may be an effective parameter to predict post-pancreaticoduodenectomy clinically relevant postoperative pancreatic fistula.

Background: The clinically relevant postoperative pancreatic fistula (CR-POPF) is significantly correlated with a high post-pancreaticoduodenectomy (PD) mortality rate. Several studies have reported an association between visceral obesity and CR-POPF. Nevertheless, there are many technical difficulties and controversies in the measurement of visceral fat.

Predominance of comammox bacteria among ammonia oxidizers under low dissolved oxygen condition.

Although low-oxygen nitrification can significantly cut down the aeration demand in wastewater treatment plants, little is known about the community dynamics of relevant microorganisms under different oxygen concentrations. Here, by conducting a series of bioreactors with oxygen concentrations of 0%, 2%, 5%, 10%, 20%, 40%, and 70%, we provided a comprehensive investigation on the behaviors and performances of comammox bacteria (CMX), ammonia-oxidizing bacteria (AOB) and archaea (AOA) during the nitrification process. Quantitative PCR analysis demonstrated that CMX was the dominant ammonia-oxidizer under low oxygen condition (10%) after the four-month operation with the abundance increased by 8.

Cortical VIP Interneurons in the Upper and Deeper Layers Are Transcriptionally Distinct.

Different interneuron classes have distinct laminar distribution patterns which contribute to the layer-specific organization of cortical microcircuits. However, laminar differences within the same interneuron classes are not well recognized. Despite systematic efforts towards neuron cell-type taxonomy in the neocortex by single-cell transcriptomics, less attention has been driven towards laminar differences in interneurons compared to projection neurons.

Human umbilical cord mesenchymal stem cells-derived exosomes for treating traumatic pancreatitis in rats.

Background: The therapeutic and protective effects of human umbilical cord mesenchymal stem cells-exosomes (hucMSC-Exs) on traumatic pancreatitis (TP) remain unknown. Here, we established a rat model of TP and evaluated and compared the therapeutic effects of hUC-MSCs and hucMSC-Exs.

Methods: HucMSC-Exs were obtained by ultracentrifugation and identified using transmission electron microscopy and western blot analysis.