Illuminating Lead Coordination in Perovskite Precursors via Fluorescence Spectroscopy.

The properties of perovskite precursors critically determine the ultimate performance of perovskite devices, yet simple and accessible real-time precursor characterization methods remain scarce. Here, we systematically investigate the lead (Pb) coordination environment in perovskite precursors using fluorescence spectroscopy. By examining lead halide [PbX6]⁴- octahedra (X = Cl, Br, I) and monitoring their luminescence under different solvents and A-site cation compositions, we unveil how [PbX6]⁴- distinct aggregation states give rise to characteristic fluorescence "fingerprints.

Predictive Modeling of Endograft Limb Occlusion After Endovascular Aneurysm Repair: A Propensity Score Matching Analysis.

Background: Endovascular aneurysm repair (EVAR) is widely used to treat abdominal aortic aneurysm (AAA). However, it carries the risk of complications that often require further interventions. Endograft limb occlusion (ELO), though relatively rare, significantly affects patient outcomes.

Neuropilin-1-target self-assembled peptide nanoparticles contribute to tumor treatment by inducing pyroptosis.

Background: Expression of the Neuropilin-1 (NRP1) is reported in malignant cells of multiple human tumor types represented as a tumor marker. Targeting NRP1 with a peptide, CK3, is used for tumor molecular imaging, raising the question of the therapeutic potential of CK2, a peptide with a CK3 backbone which enhanced targeting and tumor enrichment properties.

Methods: The tumor targeting and enrichment capacity of CK2 was detected by IncuCyte, flow cytometry and animal living imaging.

Unveiling the Role of Alkyl Chain in Boosting Antibacterial Selectivity and Cell Biocompatibility.

Cationic amphiphiles have been demonstrated to be superior targeted antibacterial agents whose antibacterial activity exhibits a close relationship with their alkyl chain substituents. However, a systematic and deep investigation of the structure-property relationship is still pending. Meanwhile, cationic amphiphiles have a risk of accumulating in living mammalian cells, which poses a great threat to biosafety and clinical applications.

Human transmembrane protein 68 links triacylglycerol synthesis to membrane lipid homeostasis.

Transmembrane protein 68 (TMEM68) is a recently identified mammalian triacylglycerol (TAG) synthase with high expression in the brain. How TMEM68 regulates cellular lipid metabolism in concert with other enzymatic pathways remains poorly understood. In this study, we assessed TMEM68 function in neuro- and glioblastoma cells by combining genetic gain- and loss-of-function approaches with lipidomics.

Reading motivation and reading comprehension achievement among English majors in China: A descriptive correlational study.

This study explores the relationship between reading motivation and reading comprehension achievement among English major students in China, an area that has received limited attention in existing literature. Drawing on previous research emphasizing the importance of reading motivation in improving reading skills, this study seeks to examine the connection between reading motivation and reading comprehension achievement within the specific research context. The Pearson correlation coefficient showed a significant positive correlation between reading motivation and reading proficiency among English major students at a Chinese private undergraduate university.

Patients with multiple mpMRI region of interests: should we omit targeted biopsies of secondary lesions?

Purpose: To assess the value of secondary lesion-targeted biopsy (SLx) in detecting prostate cancer (PCa) among patients with multifocal disease.

Methods: A total of 298 biopsy-naïve patients with 612 lesions (all with Prostate Imaging Reporting and Data System [PI-RADS] v2.1 ≥ 3) underwent cognitive fusion-targeted biopsy (TB) combined with systematic biopsy (SB).

Ultrafine Nanoparticle Rh/CeO-ZrO Catalysts Synthesized via Spatial Confinement: Higher Three-Way Catalytic Activity Compared to Rh Single-Atom Catalyst.

The synthesis of size-controlled ultrafine metal-based catalysts is vitally important for chemical conversion technologies. This study presents a spatial confinement strategy for the synthesis of Rh/CeO-ZrO (0.5 wt % Rh) three-way catalysts with ultrafine Rh nanoparticles (1-3 nm).

Renewal of wheat cultivars enhances ozone resistance in yield but detrimentally impacts quality: a survey of Chinese wheat.

The aggravation of ozone (O) pollution poses a significant threat to agricultural production. With China being the leading wheat producer of the world, contributing 17.8% to global output, the vulnerability of wheat to O is of particular concern.

Split crRNA Precisely Assisted Cas12a Expansion Strategy for Simultaneous, Discriminative, and Low-Threshold Determination of Two miRNAs Associated with Multiple Sclerosis.

Multiple sclerosis (MS) can proceed into secondary progressive MS accompanied by persistent neurological deterioration; therefore, accurate diagnosis of MS is of vital significance. Irregularities of microRNAs (miRNAs) expression have been observed in MS, so miRNAs have been evaluated as novel biomarkers and therapeutic targets. Herein, a new strategy named plit crRNA recisely ssisted as12a xpansion (SPACE) was developed for simultaneous, discriminative, and low-threshold determination of two MS-related miRNAs: miRNA-155 and miRNA-326.

Photothermal antimicrobial guar gum hydrogel cross-linked by bioactive small molecule lysine for infected wound healing.

The healing of bacteria-infected wounds has long posed a significant clinical challenge. Traditional hydrogel wound dressings often lack self-healing properties and effective antibacterial characteristics, making wound healing difficult. In this study, a bioactive small molecule cross-linking agent 4-FPBA/Lys/4-FPBA (FLF) composed of 4-formylphenylboronic acid (4-FPBA) and lysine (Lys) was utilized to cross-link guar gum (GG) and a tannic acid/iron (TA/Fe) chelate through multiple dynamic bonds, leading to the formation of a novel self-healing hydrogel dressing GG-FLF/TA/Fe.

Multifunctional self-healing and pH-responsive hydrogel dressing based on cationic guar gum and hyaluronic acid for on-demand drug release.

Pathogen invasion and persistent inflammatory storms caused by bacterial infections are the main challenges to the healing of infected wounds. Herein, this study proposed a pH-responsive polysaccharide hydrogel dressing (CG-HA) composed of cationic guar gum (CG) and hyaluronic acid (HA). Additionally, Zn and ferulic acid (FA)/β-cyclodextrin (β-CD) inclusion complexes (FA/β-CD) were co-introduced into the CG-HA hydrogel to form the desired FA/β-CD@CG-HA-Zn hydrogel.

Downregulation of MerTK in circulating T cells of patients with non-proliferative diabetic retinopathy.

Objective: To explore the differential gene expression in peripheral blood immune cells of individuals with type 2 diabetes mellitus (DM), comparing those with and without non-proliferative diabetic retinopathy (NPDR).

Methods: From a pool of 126 potential participants, 60 were selected for detailed analysis. This group included 12 healthy donors (HDs), 22 individuals with DM, and 26 with NPDR.

Decreased prefrontal activation during verbal fluency task after repetitive transcranial magnetic stimulation treatment for depression in Alzheimer's disease: a functional near-infrared spectroscopy study.

Background: Studies have shown the clinical effects of repetitive transcranial magnetic stimulation (rTMS) on depression in Alzheimer's disease (AD). However, the underlying mechanisms remain poorly understood. The measurement of brain activation links neurobiological and functional aspects but is challenging in patients with dementia.

Acceptor Elongation Boosted Intersystem Crossing Affords Efficient NIR Type-I and AIE-Active Photosensitizers for Targeting Ferroptosis-Based Cancer Therapy.

Photosensitizers (PSs) featuring type I reactive oxygen species (ROS) generation and aggregation-induced emission (AIE) activity offer a promising solution to achieve non-invasive and precise theranostics. However, the reported AIE luminogens (AIEgens) with both AIE characteristic and strong type-I ROS generation are still scarce and the structure-property relationship is still unclear. Herein, an innovative acceptor elongation boosted intersystem crossing (AEBIC) design strategy has been proposed to endow the AIEgen strong type-I ROS producibility.

Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics.

The two contradictory entities in nature often follow the principle of unity of opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor-acceptor (D-A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential to revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing to the distorted configurations, the ceilings of their photon-harvesting capability and the corresponding phototheranostic performance still fall short.

Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE.

Helicobacter pylori (H. pylori) infection is a well-established risk factor for gastric cancer, primarily due to its virulence factor, cytotoxin-associated gene A (CagA). Although PD-L1/PD-1-mediated immune evasion is critical in cancer development, the impact of CagA on PD-L1 regulation remains unclear.

Evaluation of an acne lesion detection and severity grading model for Chinese population in online and offline healthcare scenarios.

Accurate acne severity grading is crucial for effective clinical treatment and timely follow-up management. Although some artificial intelligence methods have been developed to automate the process of acne severity grading, the diversity of acne image capture sources and the various application scenarios can affect their performance. Therefore, it's necessary to design special methods and evaluate them systematically before introducing them into clinical practice.

An Iterative Pseudo Label Generation framework for semi-supervised hyperspectral image classification using the Segment Anything Model.

Hyperspectral image classification in remote sensing often encounters challenges due to limited annotated data. Semi-supervised learning methods present a promising solution. However, their performance is heavily influenced by the quality of pseudo labels.

Intramolecular Repulsive Interactions Enable High Efficiency of NIR-II Aggregation-Induced Emission Luminogens for High-Contrast Glioblastoma Imaging.

Strategies to acquire high-efficiency luminogens that emit in the second near-infrared (NIR-II, 1000-1700 nm) range are still rare due to the impediment of the energy gap law. Herein, a feasible strategy is pioneered by installing large-volume encumbrances in a confined space to intensify the repulsive interactions arising from overlapping electron densities. The experimental results, including smaller coordinate displacement, reduced reorganization energy, and suppressed internal conversion, demonstrate that the repulsive interactions assist in the inhibition of radiationless deactivation.

An efficiency improvement method for high-voltage nanosecond pulse spiral generator based on optimized voltage wave propagation process.

The spiral generator, based on the principle of the electric field vector inversion, is capable of delivering repetitive high-voltage nanosecond pulses in the commercial portable pulsed x-ray source and gas switch trigger source. However, the spiral generator suffers from extremely low output efficiency, which significantly affects the compactness and accelerates the insulation film breakdown at electrode foil edges since the high charging voltage is required. A novel output efficiency improvement method for the spiral generator was proposed, implementing the permalloy film inside the passive layer to optimize internal voltage wave propagation processes during the pulser erection.

Aggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging.

A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome the limitations of traditional fluorescent probes but also improve the boundaries of high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior imaging performance.