Automated Volumetric Milling Area Planning for Acoustic Neuroma Surgery via Evolutionary Multi-Objective Optimization.

Mastoidectomy is critical in acoustic neuroma surgery, where precise planning of the bone milling area is essential for surgical navigation. The complexity of representing the irregular volumetric area and the presence of high-risk structures (e.g.

Type I Interferon (IFNd) enhanced the innate immune response and lipid droplets (LDs) formation in obscure puffer Takifugu obscurus.

As one member of type I IFN, IFNd showed huge distinctive responses and activity during the viral or bacterial infection in various fish species. Our previous study identified IFNd from obscure puffer Takifugu obscurus (ToIFNd), and the function and regulation of ToIFNd was further investigated in the present study. The transcriptional levels of ToIFNd were significantly induced post bacteria Vibrio harveyi and virus simulator Poly (I:C) stimulation in the head kidney.

Development and external validation of a machine learning model for brain injury in pediatric patients on extracorporeal membrane oxygenation.

Background: Patients supported by extracorporeal membrane oxygenation (ECMO) are at a high risk of brain injury, contributing to significant morbidity and mortality. This study aimed to employ machine learning (ML) techniques to predict brain injury in pediatric patients ECMO and identify key variables for future research.

Methods: Data from pediatric patients undergoing ECMO were collected from the Chinese Society of Extracorporeal Life Support (CSECLS) registry database and local hospitals.

Quadruple-band synglisis enables high thermoelectric efficiency in earth-abundant tin sulfide crystals.

Thermoelectrics have been limited by the scarcity of their constituent elements, especially telluride. The earth-abundant, wide-bandgap ( ≈ 46 ) tin sulfide (SnS) has shown promising performance in its crystal form. We improved the thermoelectric efficiency in SnS crystals by promoting the convergence of energy and momentum of four valance bands, termed quadruple-band synglisis.

Prevalence and risk factors of concomitant malleolar and fibular fractures in patients with distal spiral tibial shaft fractures.

Purpose: (1) To evaluate the incidence and combination types of concomitant malleolar and fibular fractures in patients with distal spiral tibial shaft fractures. (2) To evaluate the risk factors for concomitant malleolar fractures in patients with distal spiral tibial shaft fractures.

Methods: A retrospective review was performed on 64 cases of surgically treated distal spiral tibial shaft fractures with complete radiographs and computed tomography (CT) scans.

Characterization and genomic analysis of a jumbo phage, PG216, with broad lytic activity against several Vibrio species.

In this study, a lytic phage, named PG216, was obtained from seawater collected in Qingdao, using Vibrio parahaemolyticus strain G299 as its host. Transmission electron microscopy revealed that phage PG216 has an icosahedral head with a diameter of 100 ± 6.7 nm and a contractible tail with a length of 126 ± 6.

Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction.

Chronic allodynia stemming from peripheral stump neuromas can persist for extended periods, significantly compromising patients' quality of life. Conventional managements for nerve stumps have demonstrated limited effectiveness in ensuring their orderly termination. In this study, we present a spatially confined conduit strategy, designed to enhance the self-organization of regenerating nerves after truncation.

Depressive symptoms among the oldest-old in China: a study on rural-urban differences.

Background: In China, In China, depression among the oldest-old (aged 80 + years) is a major public health issue. As the gap in development between urban and rural China widens, the aim of this study was to demonstrated whether there are disparities in the incidence of depressive symptoms between the urban and rural oldest-old (aged 80+) in China and to quantify the contribution of relevant influencing factors.

Methods: The study evaluated data on 5,116 oldest adults (female, 55.

YBX1: A Multifunctional Protein in Senescence and Immune Regulation.

The Y-box binding protein 1 (YBX1) is a multifunctional protein with a wide range of roles in cell biology. It plays a crucial role in immune modulation, senescence, and disease progression. This review presents a comprehensive analysis of the specific functions and mechanisms of YBX1 in these areas.

CRISPR/Cas12a-Enabled Amplification-Free Colorimetric Visual Sensing Strategy for Point-of-Care Diagnostics of Biomarkers.

CRISPR/Cas12a-based biosensors have garnered significant attention in the field of point-of-care testing (POCT), yet the majority of the CRISPR-based POCT methods employ fluorescent systems as report probes. Herein, we report a new CRISPR/Cas12a-enabled multicolor visual biosensing strategy for the rapid detection of disease biomarkers. The proposed assay provided vivid color responses to enhance the accuracy of visual detection.

U-Shaped Relationship Between MSpO Levels and the Incidence of Frailty in Elderly OSA Patients: Findings from a Multicenter Cohort Study.

Background: Previous studies have demonstrated a significant correlation between obstructive sleep apnea (OSA) and frailty. However, the association of mean pulse oxygen saturation (MSpO) with frailty among OSA patients remains unconfirmed. This study aimed to explore this potential association using data from a multicenter, prospective cohort.

Decomposition Analysis of the Prevalence of Denture Use Between Rural and Urban Older Individuals With Edentulism in China: Cross-Sectional Study.

Background: Edentulism impacts the physical health and quality of life of older individuals. The prevalence, influencing factors, and differences in terms of edentulism in urban and rural areas of China are unclear.

Objective: This study investigated the denture-wearing conditions and causes affecting older patients with edentulism in urban and rural areas of China and analyzed the differences.

Three-dimensional distribution of subchondral fracture lines in osteonecrosis of the femoral head.

Objective: To investigate the characteristics of three-dimensional distribution of subchondral fracture lines on the surface of the osteonecrosis femoral head, and to discuss the underlying mechanisms that contribute to its collapse.

Methods: We retrospectively analyzed computed tomography (CT) images from 75 patients (comprising a total of 77 femoral heads) diagnosed with Association Research Circulation Osseous (ARCO) stage IIIA or IIIB femoral head necrosis. The three-dimensional structures of both the femoral head and the subchondral fracture line were reconstructed and subsequently fitted into normal femoral head model.

Preparation of composite film based on corn starch and soybean fiber composites blended in 1-ethyl-3-methylimidazolium chloride.

Background: To overcome the deficiency of pure starch in film-forming performance, ionic liquids (ILs) have been introduced when preparing a homogeneous blend of starch and fiber. It is essential to select the appropriate ratio of starch to fiber and evaluate the film-forming property of the resulted composites. In the present study, 1-ethyl-3-methylimidazolium chloride ([EMIM]Cl) was used to prepare composites of soybean fiber (SF) and corn starch (CS) at various ratios.

Roles of S100A1 and S100A10 from hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀) in immune response to Vibrio infection.

The S100 proteins are highly conserved EF-hand calcium-binding proteins found only in vertebrates. In the current study, two S100 genes (S100A1 and S100A10) were successfully identified and characterized from hybrid grouper Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀. The deduced S100A10 protein contained two EF-hand domains, and S100A1 only possessed the N-terminal EF-hand.

Cellular crosstalk in the bone marrow niche.

The bone marrow niche is a special microenvironment that comprises elements, including hematopoietic stem cells, osteoblasts, and endothelial cells, and helps maintain their characteristic functions. Here, we elaborate on the crosstalk between various cellular components, hematopoietic stem cells, and other cells in the bone marrow niche. We further explain the mechanism of preserving equilibrium in the bone marrow niche, which is crucial for the directional regulation of bone reconstruction and repair.

A multi-band spectral data fusion method for improving the accuracy of quantitative spectral analysis.

The signal-to-noise ratio of the spectrum is a critical determinant of detection accuracy in compositional analysis utilizing spectroscopy. The spectral data acquired by the spectrometer, while intended to capture essential sample characteristics, is often interspersed with various noise interferences. This contamination can severely disrupt the integrity of measurement outcomes.

Effects of loneliness on short video addiction among college students: the chain mediating role of social support and physical activity.

Unlabelled: Loneliness is a common public health problem that affects physical and mental health. Prior research has demonstrated a connection between internet addiction and loneliness. Short video addiction is a novel internet addiction.

A preliminary investigation on the protective effects of β-glucan and mannan induced trained immunity in pufferfish Takifugu obscurus.

Immune stimuli are able to trigger long-term protective effects through mechanisms of trained immunity, which has attracted increasing attention. Although the existence of trained immunity has evidenced in teleost fish, while there were no such reports in pufferfish (Takifugu obscurus) so far. Therefore, the present study aimed to evaluate the induction of β-glucan and mannan on the trained immunity and their protective efficacy against Vibrio harveyi re-stimulation in pufferfish.

Identification and characterization of 16 tripartite motif-containing proteins from Takifugu obscurus.

Tripartite motif-containing (TRIM) proteins play important roles in apoptosis, development, autophagy, and innate immunity in vertebrates. In this study, a total of 16 TRIM genes were cloned and identified from obscure puffer Takifugu obscurus. Multiple alignment results showed that most of the deduced ToTRIM proteins contained three typical motifs, a really interesting new gene (RING) zinc-finger domain, one B-box, and a coiled-coil domain, which together formed the TRIM motif found in this large family of proteins.

Effects of short video addiction on college students' physical activity: the chain mediating role of self-efficacy and procrastination.

Introduction: Excessive use of short video applications can adversely affect the physical and mental health of college students. At present, regarding the effect of short video addiction on physical exercise, few scholars have studied the mechanism of action. This study aims to investigate the mechanism by which short video addiction impacts college students' physical exercise.

Impact of mutations in carbohydrate binding sites of tandem-repeat type galectin from Takifugu obscurus on its antimicrobial activity.

Galectins belong to a family of galactoside-binding proteins and exhibit diverse biological functions. In the present research, a tandem-repeat type galectin (named ToGalectin) was identified from obscure puffer Takifugu obscurus. The 296 amino acids ToGalectin contained two carbohydrate recognition domains (CRDs), one of which possessed two conserved carbohydrate binding motifs.

Recognition of novel proteins encoded by an aquareovirus using mass spectrometry.

AQUAREOVIRUS: a genus of within the family Spinareoviridae, order Reovirales, infects aquatic animals. Their genomes comprise 11 segments of double-stranded RNA, which function directly as mRNAs upon release into the cytoplasm of infected cells. Here, liquid chromatography-tandem mass spectrometry was employed to annotate small coding ORFs in the Aquareovirus-C genome.