Dual-Stage Stacking Machine Learning Method Considering Virtual Sample Generation for the Prediction of ZIF-8' BET Specific Surface Area with Experimental Validation.

The widespread application of metal-organic frameworks (MOFs) in wastewater and gas treatment has created an increasing demand for accurate and rapid assessment of their BET specific surface area. However, experimental methods for acquiring sufficient statistical data are often costly and time-consuming. Therefore, this study proposes a dual-stage stacking model with Gaussian mixture model-virtual sample generation (GMM-VSG) technology for the BET specific surface area prediction.

Engineering the acoustic field with a Mie scatterer for microparticle patterning.

The utilization of acoustic fields offers a contactless approach for microparticle manipulation in a miniaturized system, and plays a significant role in medicine, biology, chemistry, and engineering. Due to the acoustic radiation force arising from the scattering of the acoustic waves, small particles in the Rayleigh scattering range can be trapped, whilst their impact on the acoustic field is negligible. Manipulating larger particles in the Mie scattering regime is challenging due to the diverse scattering modes, which impacts the local acoustic field.

Disulfiram impairs USP21-mediated MOF-K257 deubiquitination to inhibit esophageal squamous cell carcinoma progression.

Disulfiram (DSF), primarily applied in the therapy for alcohol addiction, has been demonstrated to possess the promising capability of anti-tumor in many human cancers, including esophageal squamous cell carcinoma (ESCC). To date, almost all studies about DSF in ESCC are focusing on investigating either drug combinations or nanoparticle-based delivery systems. However, the exact molecular mechanisms mediating the response to DSF in ESCC are totally unknown.

Informed-Learning-Guided Visual Question Answering Model of Crop Disease.

In contemporary agriculture, experts develop preventative and remedial strategies for various disease stages in diverse crops. Decision-making regarding the stages of disease occurrence exceeds the capabilities of single-image tasks, such as image classification and object detection. Consequently, research now focuses on training visual question answering (VQA) models.

Optimized mesopore design in ginkgo nuts-derived hyper-crosslinked porous carbon for enhancing supercapacitor capacitance performance.

The capacitance performance of a co-doped carbon-based supercapacitor derived from Ginkgo nuts was significantly enhanced by optimizing the mesoporous structure through high-temperature pyrolysis combined with KOH activation. The precisely engineered GBHHPC-750-4 is characterized by a hyper-crosslinked 3D hierarchical porous structure, with an exceptionally high specific surface area of 3163.9 m/g, a substantial mesopore proportion (Vmeso/Vt = 74.

Video- assisted thoracoscopic lung resection with or without enhanced recovery after surgery: a single institution, prospective randomized controlled study.

Purpose: This study was conducted to evaluate the postoperative short-term outcomes of patients undergoing video-assisted thoracoscopic surgery (VATS) for lung resection with the enhanced recovery after surgery (ERAS) protocol.

Methods: A single-institution, prospective randomized controlled study was conducted. The primary outcome measures were postoperative pulmonary complications (PPCs) and postoperative short-term effects.

Enhanced desulfurization performance of model fuel by Cu-ZnO/TiO heterostructure.

A facile hydrothermal approach was employed to synthesize a novel Cu-ZnO/TiO Z-heterojunction with a high density of defects, which was then utilized for the oxidative desulfurization process, demonstrating excellent photodegradation performance. The results showed that by adjusting components such as Cu, ZnO, and TiO, the removal efficiency of DBT reached 88.12% within a duration of 240 min.

TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis.

Intervertebral disc degeneration (IDD) is a common chronic inflammatory degenerative disease that causes lower back pain. However, the underlying mechanisms of IDD remain unclear. Ferroptosis suppressor protein 1 (FSP1) is a newly identified suppressor for ferroptosis.

Acid-responsive CST@NPs enhanced diabetic wound healing through rescuing mitochondrial dysfunction.

Diabetic ulcers (DUs) are persistent and challenging complications of diabetes. The consequences of DUs include a decline in functional status, increased risk of infection, hospitalization, and even death. Our study revealed a significant decrease in the levels of cortistatin (CST) in the skin tissue of patients with DUs and diabetic rats.

Metallic protection of soil carbon: divergent drainage effects in vs. non- wetlands.

The established paradigm assumes that drainage may decrease the vast soil organic carbon (SOC) reservoir in global wetlands. Yet drainage can also promote SOC stabilization by fostering the accrual of metal-bound organic carbon (bound OC) upon oxygen exposure. Here, this emergent mechanism is tested for the first time at a regional scale, using literature data and a nationwide, pairwise survey of drained wetlands across China.

Plant-Soil Moisture Positive Feedback Maintaining Alternative Stable States in the Alpine Marsh Ecosystem.

A self-reinforcing positive feedback is regarded as a critical process for maintaining alternative stable states (ASS); however, identification of ASS and quantification of positive feedbacks remain elusive in natural ecosystems. Here, we used large-scale field surveys to search for ASS and a positive feedback mechanism under a wide range of habitats on the Tibetan Plateau. Using multiple methods, we proved that three stable states exist that accompany alpine marsh degradation.

Polyphenol-Mediated Adhesive and Anti-Inflammatory Double-Network Hydrogels for Repairing Postoperative Intervertebral Disc Defects.

Hydrogels have garnered tremendous attention for their applications in the repair of intervertebral disk (IVD) degeneration and postoperative IVD defects. However, it is still challenging to develop a hydrogel fulfilling the requirements for high mechanical properties, adhesive capability, biocompatibility, antibacterial properties, and anti-inflammatory performance. Herein, we report a multifunctional double-network (DN) hydrogel composed of physically cross-linked carboxymethyl chitosan (CMCS) and tannic acid (TA) networks as well as chemically cross-linked acrylamide (AM) networks, which integrates the properties of high strength, adhesion, biocompatibility, antimicrobial activity, and anti-inflammation for the repair of postoperative IVD defects.

Reserpine, a novel N6-methyladenosine regulator, reverses Lenvatinib resistance in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is an aggressive malignancy and a growing global health problem. Reserpine (Res), a plant-derived hypertension drug, has been reported to possess anti-tumor efficacy. However, the role and function of Res in N6-methyladenosine (m6A) regulation and Lenvatinib (Len) resistance in HCC have not been clarified.

Bacterial communication intelligently regulates their interactions in anammox consortia under decreasing temperatures.

Bacterial communication could affect their interactions, but whether this regulation has "intelligence" is still unknown. Here, we operated an anammox reactor under temperature gradient from 35 °C to 15 °C. As results, expression abundance of bacterial communication genes increased by 12 % significantly after temperature declined.

Biomass Derived Self-Doped Carbon Nanosheets Enable Robust Hole Transport Layers with Ion Buffer for Perovskite Solar Cells.

The diffusion of iodine species and lead leakage during device degradation represent the main obstacles restricting the commercial application of perovskite solar cells (PSCs). Cobalt loaded ultrathin carbon nanosheets (Co(III)-CNS) derived from biomass are prepared as ion buffer material to construct robust hole transport layers (HTLs). The carbon nanosheets containing trivalent cobalt ions can facilitate the oxidation of the hole transport material while preserving the structural integrity and electrical properties of HTLs under thermal stress, thereby ensuring efficient carrier transport.

Short-term choroidal changes as early indicators for future myopic shift in primary school children: results of a 2-year cohort study.

Background: To assess predictive value of short-term choroidal changes for future myopic shift in children.

Methods: 577 eyes of 289 primary school children were prospectively followed for 2 years. Cycloplegic refractions at baseline, 1 year and 2 years, and choroidal measurements by optical coherence tomography at baseline and 3 months, were used for analyses.

GDF11 protects against mitochondrial-dysfunction-dependent NLRP3 inflammasome activation to attenuate osteoarthritis.

Introduction: Osteoarthritis (OA) is a highly prevalent degenerative disease worldwide, and tumor necrosis factor (TNF-α) is closely associated with its development. Growth differentiation factor 11 (GDF11) has demonstrated anti-injury and anti-aging abilities in certain tissues; however, its regulatory role in OA remains unclear and requires further investigation.

Objectives: To identify whether GDF11 can attenuate osteoarthritis.

METTL14-mediated upregulation of lncRNA HOTAIR represses PP1α expression by promoting H3K4me1 demethylation in oxycodone-treated mice.

N6-methyladenosine (m6A) methylation is a vital epigenetic mechanism associated with drug addiction. However, the relationship between m6A modification and oxycodone rewarding is less well explored. Based on an open field test, the present study evaluated oxycodone rewarding using chromatin immunoprecipitation PCR, immunofluorescence, and RNA sequencing.

BDNF-loaded chitosan-based mimetic mussel polymer conduits for repair of peripheral nerve injury.

Care for patients with peripheral nerve injury is multifaceted, as traditional methods are not devoid of limitations. Although the utilization of neural conduits shows promise as a therapeutic modality for peripheral nerve injury, its efficacy as a standalone intervention is limited. Hence, there is a pressing need to investigate a composite multifunctional neural conduit as an alternative treatment for peripheral nerve injury.

USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling.

Lacking effective therapeutic targets heavily restricts the improvement of clinical prognosis for patients diagnosed with esophageal squamous cell carcinoma (ESCC). Ubiquitin Specific Peptidase 21 (USP21) is dysregulated in plenty of human cancers, however, its potential function and relevant molecular mechanisms in ESCC malignant progression as well as its value in clinical translation remain largely unknown. Here, in vitro and in vivo experiments revealed that aberrant upregulation of USP21 accelerated the proliferation and metastasis of ESCC in a deubiquitinase-dependent manner.

Sex Identification Methods Using Hyperspectral Imaging and Machine Learning.

L. is a rare dioecious species that is valued for its diverse applications and is cultivated globally. This study aimed to develop a rapid and effective method for determining the sex of a .

Case report: Simultaneous resections of pulmonary segment and an esophageal leiomyoma during spontaneous ventilation video-assisted thoracoscopic surgery.

Spontaneous ventilation video-assisted thoracoscopic surgery (SV-VATS) has rapidly developed in recent years. The application scope is still being continuously explored. We describe a case in which a 40-year-old woman with mixed ground-glass opacity (GGO) and an esophageal leiomyoma successfully underwent simultaneous segmentectomy and leiomyoma resection through spontaneous ventilation video-assisted thoracoscopic surgery.