Application Progress of Electron Beam Radiation in Adsorption Functional Materials Preparation.

To solve the problems of water and air pollution, adsorption functional materials (ASFMs) have been extensively investigated and applied. Among the preparation methods of ASFM, electron beam radiation (EBR) has attracted much attention for its high efficiency, environmental friendliness, and wide applicability. Based on the introduction of the application of EBR technology, the EBR preparation of ASFM is summarized by grafting and cross-linking.

Effects of Low Concentrations of Hypochloric Acid on the Agricultural Soil Properties.

The oxidant (e.g., hypochlorous acid, HClO) has been widely used to remediate contaminated sites.

Distinct prelimbic cortex ensembles encode response execution and inhibition.

Learning when to initiate or withhold actions is essential for survival and requires integration of past experiences with new information to adapt to changing environments. While stable prelimbic cortex (PL) ensembles have been identified during reward learning, it remains unclear how they adapt when contingencies shift. Does the same ensemble adjust its activity to support behavioral suppression upon reward omission, or is a distinct ensemble recruited for this new learning? We used single-cell calcium imaging to longitudinally track PL neurons in rats across operant food reward Training, Extinction and Reinstatement, trained rat-specific decoders to predict trial-wise behavior, and implemented an deletion approach to characterize ensemble contributions to behavior.

DPHC from Alpinia officinarum Hance specifically modulates the function of CENPU in the cell cycle and apoptosis to ameliorate hepatocellular carcinoma.

Ethnopharmacological Relevance: Alpinia officinarum Hance (A. officinarum), a perennial herb used in the treatment of digestive system cancers, holds significant value for the Li people of Hainan as a traditional Chinese medicine. (R)-5-hydroxy-1,7-diphenyl-3-heptanone (DPHC), a diarylheptanoid component is derived from A.

MAEST: accurately spatial domain detection in spatial transcriptomics with graph masked autoencoder.

Spatial transcriptomics (ST) technology provides gene expression profiles with spatial context, offering critical insights into cellular interactions and tissue architecture. A core task in ST is spatial domain identification, which involves detecting coherent regions with similar spatial expression patterns. However, existing methods often fail to fully exploit spatial information, leading to limited representational capacity and suboptimal clustering accuracy.

[A successful interventional treatment of recurrent bleeding after tonsil surgery in children].

The patient, a 10-year-old and 4-month-old boy, was admitted to the hospital "with a history of 19 days since tonsil surgery and 11 days of recurrent hematemesis". 19 days ago, bilateral endoscopic tonsil + adenoid plasma melting and bilateral tonsil fossa inferior pole suture were performed in the outer hospital, and recurrent hematemesis occurred 11 days ago, accompanied by transient fatigue and abdominal pain, diagnosis: ①Hematemesis to be investigated: postoperative tonsil bleeding? Upper gastrointestinal bleeding?②Acute moderate hemorrhagic anemia. On the first and third days of admission, the child had two sudden episodes of massive hematemesis, both of which were more than 1 000 mL, with pale lips, fatigue, and hemorrhagic shock.

SIRT3 suppresses vascular endothelial senescence via DHRS2 and contributes to the anti-vascular aging effect of Bazi Bushen capsule.

Aims: Vascular and endothelial aging are significant causes of chronic diseases among the elderly. This study investigated the specific mechanism by which sirtuin 3 (SIRT3) regulates vascular endothelial senescence and the beneficial role of Bazi Bushen capsule (BZBS) in preventing vascular aging.

Methods: Human umbilical vein endothelial cells and mouse aortic endothelial cells were cultured with D-galactose (D-gal) to induce aging and evaluate the beneficial effects of the SIRT3-dehydrogenase/reductase member 2 (DHRS2) axis on the inhibition of vascular endothelial aging.

Circulating mitochondrial DNA promotes M2 polarization of tumor associated macrophages and HCC resistance to sorafenib.

Mitochondrial damage-associated molecular patterns (DAMPs) including mitochondrial DNA (mtDNA), TFAM (transcription factor A, mitochondrial), and ATP, which play crucial roles in the regulation of inflammatory environment in human diseases. However, the role of mitochondrial DAMPs in regulating tumor microenvironment (TME) remains unclear. Herein, we demonstrate that infiltration of M2-type tumor-associated macrophages (TAMs) was correlated with the resistance of hepatocellular carcinoma (HCC) to sorafenib.

A novel ferroptosis inhibitor phenothiazine derivative reduces cell death and alleviates neurological impairments after cerebral hemorrhage.

The precise etiology of brain injury induced by intracerebral hemorrhage (ICH) remains unclear. Currently, there are no effective therapeutic options available to slow down or prevent the progression of the disease. An increasing body of evidence suggests that ferroptosis plays a significant role in the development of injury related to ICH.

Spatial interpolation and spatiotemporal scanning analysis of human brucellosis in mainland China from 2012 to 2018.

Despite the considerable efforts made to address the issue of brucellosis worldwide, its prevalence in dairy products continues to be difficult to estimate and represents a significant public health concern globally. The aim of the present study was to gain a better understanding of the epidemiology of this disease in mainland China. We set out to investigate the annual spatial distribution and potential hotspots of the disease.

Segmentation of Carotid Arteries From Three-Dimensional Black-Blood Magnetic Resonance Imaging With Sparse Annotation Using a Multi-Dimensional Hybrid Model.

Quantification of carotid atherosclerosis is important in monitoring patients at risk of cardiovascular events and in evaluating therapies. High-resolution 3D carotid magnetic resonance imaging (MRI) has been developed to provide extended coverage of the carotid arteries. However, the extended coverage poses a challenge as several hundreds of 2D axial images are required to be segmented for analysis.

Structural and Functional Insights into GGCX-FIX Interaction: Implications for Vitamin K-Dependent Bleeding Disorders.

Gamma-carboxylation, catalyzed by γ-glutamyl carboxylase (GGCX), is a critical post-translational modification essential for the biological activity of vitamin K-dependent proteins (VKDPs). Mutations in GGCX, depending on their specific location, result in vitamin K-dependent coagulation factor deficiency type 1 (VKCFD1), which encompasses a broad spectrum of clinical manifestations ranging from mild to severe, including bleeding disorders, osteoporosis, and vascular calcification. The limited knowledge of GGCX's structure and functional regions hinders our understanding of the consequences of GGCX mutations and the treatment for VKCFD1.

Brain-wide presynaptic networks of functionally distinct cortical neurons.

Revealing the connectivity of functionally identified individual neurons is necessary to understand how activity patterns emerge and support behaviour. Yet the brain-wide presynaptic wiring rules that lay the foundation for the functional selectivity of individual neurons remain largely unexplored. Cortical neurons, even in primary sensory cortex, are heterogeneous in their selectivity, not only to sensory stimuli but also to multiple aspects of behaviour.

MicroRNA-21 Promotes the Viability, Proliferation and Milk Fat Synthesis of Ovine Mammary Epithelial Cells by Targeting .

MicroRNAs (miRNAs) are short endogenous non-coding RNAs and play important roles in regulating mammary development and activities of ovine mammary epithelial cells (OMECs), which affect the milk yield and milk ingredient contents of ewes. We previously found that miR-21 was highly expressed in ovine mammary tissue, while the regulatory mechanisms of miR-21 underlying mammary development and lactation performance are still unclear. Accordingly, in this study, we investigated the functions of miR-21 in the activities of OMECs, and validated the target relationship of miR-21 with a predicted target gene programmed cell death 4 () by a dual-luciferase reporter assay.

A mini review on the regulation of coagulation homeostasis through interfering with vitamin K-dependent coagulation/anticoagulation factors.

Coagulation disorders, such as excessive bleeding or thrombosis, present significant health challenges. Vitamin K-dependent proteins (VKDPs), including coagulation and anticoagulation factors, are essential for maintaining the coagulation homeostasis due to their key roles in the coagulation cascade. Therefore, VKDPs have become significant targets for regulating coagulation homeostasis, and various strategies have been developed, primarily including small molecule drugs and nanomaterials.

Integrated internal and external exposure models for dimethylformamide risk assessment and health risk monetization.

Long-term exposure to chemicals can cause chronic health damage in occupational workers, and traditional risk assessment methods are no longer sufficient to comprehensively evaluate these chronic effects. Therefore, it is crucial to explore risk assessment methods that are more suited to the typical exposure environments of occupational workers. Herein, we conducted on-site concentration measurements and health effect analyses of 1040 dimethylformamide-exposed workers at 19 enterprises in Jiangsu Province, performed probabilistic health risk assessment of the sampling results, and report the first definition of the liver injury weights.

The mediating effect of character strengths on the relationship between clinical nurses' mental health literacy and work engagement.

Background: As the main force of clinical work, nurses' work engagement level will directly affect nursing quality. A high level of work engagement helps to improve nurses' work performance, quality of nursing, and job satisfaction. Mental health literacy education can effectively improve work engagement.

Endothelial monocarboxylate transporter 1 drives atherosclerosis via a lactate/NADH/CtBP-mediated transrepression pathway.

The accumulation of lactate in tissue microenvironments is associated with atherosclerosis, but its precise role in atherogenesis remains largely unknown. This study demonstrated that lactate accumulation in aortic tissues and blood is correlated with increased monocarboxylate transporter 1 (Mct1) expression in endothelial cells (ECs) within atherosclerotic plaques. Lactate uptake via Mct1 triggers an inflammatory response in ECs.

Multimedia distribution and exchange characteristics of organophosphorus flame retardants in a typical semi-arid city in China.

After the ban on polybrominated diphenyl ethers (PBDEs), the replacement of these compounds with organophosphorus flame retardants (OPFRs) has drawn widespread attention worldwide. In arid/semi-arid regions, characteristics such as low precipitation, frequent strong winds, and low soil organic carbon content potentially influence the environmental fate of OPFRs. In this study, we investigated the concentrations of nine OPFRs in water, sediment, soil, air, and dry deposition in Lanzhou, an arid/semi-arid region in China.

Study on improving yield and antioxidant enzyme activities in millet by rationing molybdenum and nitrogen.

The application of appropriate nitrogen and molybdenum fertilizer can improve the growth and development of plants, increase photosynthetic efficiency, regulate active oxygen metabolism , maintain the oxidation balance required for normal cell growth, enhance the activity of crop antioxidant enzymes and dry matter accumulation, so as to increase crop yield. In order to investigate the effect mechanism of nitrogen fertilizer combined with foliar molybdenum fertilizer on millet yield and antioxidant enzyme activity, two nitrogen application gradients (N (0 kg/hm2) and N (75 kg/hm2) were set with millet variety Changnong 47 as material. Leaf molybdenum fertilizer Mo (0 %), Mo (0.

Changing trends in human brucellosis in pastoral and agricultural China, 2004-2019: a Joinpoint regression analysis.

Background: The incidence of human brucellosis has risen sharply in China but little is known about trends in pastoral and agricultural areas respectively. This study aimed to analyze the annual and monthly incidence trends of human brucellosis in China from 2004 to 2019. It sought to identify factors contributing to higher incidence rates at specific times and to compare incidence trends across pastoral, agricultural/pastoral, and agricultural areas.

Modulatory impact of subsp. BL21 on the gut-brain-ovary axis in polycystic ovary syndrome: insights into metabolic regulation, inflammation mitigation, and neuroprotection.

This study evaluates the efficacy of subsp. BL21 in mitigating symptoms of polycystic ovarian syndrome (PCOS) in DHT-induced PCOS model mice. It focuses on BL21's role in modulating metabolic dysregulation, inflammation, and neuroprotection via the gut-brain-ovary axis.

Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy.

Stem cell-based therapy has emerged as a promising approach for heart repair, potentially regenerating damaged heart tissue and improving outcomes for patients with heart disease. However, the efficacy of stem cell-based therapies remains limited by several challenges, including poor cell survival, low retention rates, poor integration, and limited functional outcomes. This article reviews current enhancement strategies to optimize mesenchymal stem cell therapy for cardiac repair.

Bio-nanopore technology for biomolecules detection.

Bio-nanopore technology holds great promise in biomacromolecule detection, with its high throughput and low cost positioning it as an ideal detection tool. This technology employs a unique detection mechanism that utilizes nanoscale pores to rapidly and sensitively convert biological molecules interactions into electrical signals, enabling real-time, single-molecule detection with exceptional sensitivity. This review focuses on the latest advancements in this technology across various domains, including DNA and RNA sequencing, protein detection, and small molecule identification.

Integrated omics profiling of individual variations in intestinal damage to the soybean allergen in piglets.

Introduction: A small number of soybean allergens [including Glycinin (11S) and β-Conglycinin (7S)] in the commercially available corn-soybean meal diet can still cause allergy in some weaned piglets, which may be the result of the interaction of genetic, and nutrition, but the specific mechanism is still unclear.

Methods: In this study, 20 allergic piglets and 20 non-allergic piglets were selected from 92 weaned piglets by skin sensitization tests, which were used to examine the whole sequence genome. The indicators related to humoral and cellular immunity, transcriptomics, and metabolomics analysis were determined by randomly selecting 5 boars in the allergic group and non-allergic group and then performing a validation .