Construction and preliminary trial test of a decision-making app for pre-hospital damage control resuscitation.

Purpose: To construct a decision-making app for pre-hospital damage control resuscitation (PHDCR) for severely injured patients, and to make a preliminary trial test on the effectiveness and usability aspects of the constructed app.

Methods: Decision-making algorithms were first established by a thorough literature review, and were then used to be learned by computer with 3 kinds of text segmentation algorithms, i.e.

Characterization and Identification of the Chemical Constituents and the Metabolites of Geum japonicum Thunb. var. chinense F. Bolle.

Introduction: Geum japonicum Thunb. var. chinense F.

Cyclin Y interacts with Chk1 to activate RRM2/STAT3 signaling and promotes radioresistance in non-small cell lung cancer.

Radioresistance is one of the main reasons for the recurrence and metastasis of non-small cell lung cancer. Cyclin Y has been implicated in various cellular processes such as cell growth, proliferation, autophagy, and tumor progression. However, the function and regulatory mechanism of Cyclin Y in lung cancer radioresistance remain poorly understood.

Danshensu Derivatives: A Series of Promising Drugs With Protective Effects Against Cardiocerebrovascular Diseases and Cancers.

Salvia miltiorrhiza (Danshen in Chinese) is a traditional medicinal plant with an extensive range of cardiocerebrovascular protective effects widely used in China and other Asian countries. Danshensu (DSS) is the most important water-soluble component of Danshen and has significant antioxidant, anti-inflammatory, antiplatelet aggregation, antitumor, and other pharmacological activities. However, DSS has poor fat solubility and is unstable due to its o-phenol hydroxyl and α-hydroxy carboxylic acids.

Efficacy and Safety of Third-Generation EGFR-TKIs Combined with Radiotherapy for Advanced NSCLC with Typical EGFR Mutations: A Retrospective Study.

Objective: To evaluate the efficacy and safety of third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in combination with radiotherapy (RT) for patients with advanced non-small cell lung cancer (NSCLC) harboring typical EGFR mutations.

Methods: Patients who received treatment with third-generation EGFR-TKIs alone or in combination with RT were retrospectively enrolled at a single center. The primary endpoint was progression-free survival (PFS).

Genetic landscape and ocular biometric correlations in microspherophakia: insights from a comprehensive patient cohort.

Aims: The aim of this study is to elucidate the genetic landscape of microspherophakia (MSP) and describe the genotype-phenotype correlation of MSP. Additionally, the study seeks to enhance the understanding of the pathogenic mechanisms of MSP through the discovery of novel loci.

Methods: Patients diagnosed with MSP at the Eye and ENT Hospital of Fudan University, Shanghai, were included in the study and all underwent panel-based next-generation sequencing and bioinformatics analysis.

GALR1 and PENK serve as potential biomarkers in invasive non-functional pituitary neuroendocrine tumours.

Background: Some nonfunctioning pituitary neuroendocrine tumor (NFPitNET) can show invasive growth, which increases the difficulty of surgery and indicates a poor prognosis. However, the molecular mechanism related to invasiveness remains to be further studied. This study is to screen and identify the characteristic biomarkers of invasive NFPitNETs.

TGF-β signaling in the ovary: Emerging roles in development and disease.

The TGF-β superfamily plays a pivotal role in a wide array of cellular processes, including cell proliferation, differentiation, apoptosis, and migration. It is also critically involved in ovarian development and the pathogenesis of various diseases. Within the ovary, follicles act as the primary functional units, housing numerous members of the TGF-β superfamily that regulate follicular development and, consequently, overall ovarian function.

Risk assessment of existing buildings in tunnel construction based on an improved cumulative prospect theory method.

As urbanization in China continues to rise, an increasing number of cities are constructing subway tunnels. However, due to the complexity and ambiguity of subway tunnel construction, there is a lack of precise methods to assess the impact of these constructions on surrounding buildings. Consequently, this study analyzes and summarizes past experiences and proposes the IVTSFS-CPT-EDAS model based on the CPT-EDAS evaluation method.

Biogenesis of stress granules and their role in the regulation of stress-induced male reproduction disorders.

Stress granules (SGs) are conserved messenger ribonucleoprotein (mRNP) granules that form through rapid coalescence in the cytoplasm of eukaryotic cells under stressful environments. These dynamic membrane-free organelles can respond to a variety of both intracellular and extracellular stressors. Studies have shown that stress conditions such as heat stress, arsenite exposure, and hypoxic stress can induce SGs formation.

How does light regulate plant regeneration?

Based on the totipotency and pluripotency of cells, plants are endowed with strong regenerative abilities. Light is a critical environmental factor influencing plant growth and development, playing an important role in plant regeneration. In this article, we provide a detailed summary of recent advances in understanding the effects of light on plant regeneration, with a focus on the fundamental processes and mechanisms involved in shoot regeneration, somatic embryogenesis, and adventitious root formation.

The Multiferroic, Magnetic Exchange Bias Effect, and Photodetection Multifunction Characteristics in MnSe/GaFeO Heterostructure.

Artificial heterostructures are typically created by layering distinct materials, thereby giving rise to unique characteristics different from their individual components. Herein, two-dimensional α-MnSe nanosheets with a non-layered structure were fabricated on GaFeO (GFO) films. The superior crystalline properties of MnSe/GFO heterostructures were confirmed through structural and morphological analyses.

Effect of Capsular Tension Ring on the Accuracy of Nine New-Generation IOL Formulas in Long Eyes.

Purpose: To investigate the effect of capsular tension rings (CTRs) on the accuracy of nine new-generation intraocular lens (IOL) formulas in long eyes.

Methods: A total of 106 eyes (106 patients) with CTR (CTR group) and another 106 eyes (106 patients) without CTR (NCTR group) were analyzed. The differences in mean prediction error, standard deviation, mean absolute prediction error (MAE), median absolute prediction error (MedAE), root mean square absolute prediction error (RMSAE), and percentage of eyes within ±0.

Clinical significance of ALDH1A1 and Ki67 expression in women with breast carcinoma.

Background: Breast cancer is the most prominent cancer among women worldwide, with a two-fold incidence in China compared to the worldwide incidence. ALDH1A1, catalyzing the oxidation of intracellular aldehydes and converting retinol into retinoic acid, serves as a biomarker of early stem cell differentiation. Ki67 levels are prognostic or residual risk biomarkers after primary therapy and can predict the effects of systemic therapies or monitor patients for sustained response or resistance to the administered therapies.

SH2B1 promotes apoptosis in diabetic cataract via p38 MAPK pathway.

Patients with diabetes face an increased risk of developing cataracts, with unclear mechanisms. Our study illuminates these mechanisms by identifying differentially expressed proteins in the lens anterior capsule of patients with diabetic cataract (DC) and age-related cataract using quantitative proteomics. We found SH2 domain-containing adapter protein B1 (SH2B1) to be crucial in DC progression.

TOPSIS prefabricated building construction evaluation based on interval-valued Pythagorean fuzzy numbers based on prospect theory.

Prefabricated buildings have a series of advantages such as high efficiency, energy savings, and environmental protection, and are being strongly promoted by the Chinese government. However, due to the late start of prefabricated buildings in China, the installation process of prefabricated components is relatively complex, leading to difficulties in quality and safety control. A novel evaluation methodology integrating the technique for order preference by similarity to ideal solution (TOPSIS) with prospect theory and interval-valued Pythagorean fuzzy numbers (IVPFNs) is proposed.

The cytoplasmic tail of IBV spike mediates intracellular retention via interaction with COPI-coated vesicles in retrograde trafficking.

Coronaviruses are characterized by their progeny assembly and budding in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). Our previous studies demonstrated that truncation of 9 amino acids in the cytoplasmic tail (CT) of the infectious bronchitis virus (IBV) spike (S) protein impairs its localization to the ERGIC, resulting in increased expression at the plasma membrane. However, the precise mechanism underlying this phenomenon remained elusive.

The Change of Ciliary Muscle-Trabecular Meshwork-Schlemm Canal Complex after Phacoemulsification using Swept-Source-Optical Coherence Tomography.

Introduction: Cataract surgery has been reported to have a reducing effect on intraocular pressure (IOP) in glaucomatous and non-glaucomatous eyes. This effect seems to be more noticeable in eyes with narrow angles (NAs) than in eyes with open angles (OAs). Decrease in IOP may be a result of the increase in anterior chamber angle and Schlemm canal (SC) after cataract surgery.

Ultrahigh Energy Storage Performance in BiFeO-Based Lead-Free Ceramics via Tuning Structural Homogeneity and Domain Engineering Strategies.

Lead-free ceramic-based dielectric capacitors are critical in electronics and environmental safety. Nevertheless, developing ideal lead-free ceramics with excellent energy storage properties remains a challenging task for practical applications. Herein, the enhanced relaxation behavior and increased breakdown electric field are utilized to realize the high energy storage behavior of (0.

Visual Outcomes and IOL Stability After Panoptix Trifocal Intraocular Lens Implantation in Eyes With High Myopia.

Purpose: To observe and explore the correlation between visual outcomes and intraocular lens (IOL) stability after tri-focal IOL implantation in eyes with high myopia.

Methods: Patients with highly myopic cataract (axial length > 26 mm) were enrolled in this prospective study. Thirty-one eyes (31 patients) received implantation of a trifocal IOL (AcrySof IQ PanOptix TFNT00).

Magnetic exchange coupling and photodetection multifunction characteristics of an MnSe/LaMnO heterostructure.

Artificial heterostructures are often realized by stacking different materials to present new emerging properties that are not exhibited by their individual constituents. In this work, non-layered two-dimensional α-MnSe nanosheets were transferred onto LaMnO (LMO) films to obtain a multifunctional heterostructure. The high crystal quality of the MnSe/LMO heterostructure was revealed by X-ray diffraction, Raman spectroscopy, and scanning electron microscopy measurements.

Molecular characteristics and pathogenicity analysis of infectious laryngotracheitis virus isolated in China from 2015 to 2019.

The aim of this study was to investigate the molecular characteristics and pathogenicity of recently isolated ILTV strains from China, thereby augmenting our understanding of its prevalence. The complete genome sequences of seven ILTV strains obtained from China between 2015 and 2019 were determined by high-throughput sequencing. Phylogenetic analysis showed that six isolates (SD2015, GD2017, SYB2018, HB201812, HB201806, and TJ2019) were classified together with CEO vaccine strains, while only one isolates LN2018 belonged to the wild-type cluster.

[Clinical Characteristics of Pneumocystis Jiroveci Pneumonia after Allogeneic Hematopoietic Stem Cell Transplantation].

Objective: To summarize the clinical characteristics of patients with combined pneumocystis jiroveci pneumonia (PJP) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods: The clinical manifestations, laboratory tests, imaging findings, and treatment outcomes of 21 allo-HSCT patients with PJP diagnosed at the First Affiliated Hospital of Soochow University and Soochow Hopes Hematology Hospital from July 2018 to July 2023 were retrospective analyzed.

Results: Among the 21 patients, the male -to-female ratio was 2.

Advances in research on the impact and mechanisms of pathogenic microorganism infections on pyroptosis.

Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death characterized by the activation of gasdermin proteins, leading to the formation of pores in the cell membrane, continuous cell swelling, and eventual membrane rupture. This process results in the release of intracellular contents, including pro-inflammatory cytokines like IL-1β and IL-18, which subsequently trigger a robust inflammatory response. This process is a crucial component of the body's innate immune response and plays a significant role in combating infections.