Exponential stability of infinite-dimensional impulsive stochastic systems with Poisson jumps under aperiodically intermittent control.

This paper studies the problem of mean square exponential stability (ES) for a class of impulsive stochastic infinite-dimensional systems with Poisson jumps (ISIDSP) using aperiodically intermittent control (AIC). It provides a detailed analysis of impulsive disturbances, and the related inequalities are given for the two cases when the impulse perturbation occurs at the start time points of the control and rest intervals or non-startpoints, respectively. Additionally, in virtue of Yosida approximating systems, combining with the Lyapunov method, graph theory and the above inequalities, criteria for ES of the above impulsive stochastic infinite-dimensional systems are established under AIC for these two perturbation scenarios.

The Potential of Model-Free Parameters Derived From IVIM in Evaluating Pathological Indicators and Long-Term Survival in NPC.

Background: IVIM is a useful quantitative tool for predicting prognosis, but it is labor-intensive. Simplified b-value settings and post-processing could be more practicable for clinical applications.

Purpose: To assess the value of model-free parameters (virtual MR elastography [vMRE] and signature-index [S-index]) derived from IVIM in evaluating pathological indicators and long-term survival in nasopharyngeal carcinoma (NPC), and to compare those with model-based parameters.

Structural Optimization of Microfluidic Chips for Enhancing Droplet Manipulation and Observation via Electrodynamics Simulation.

Digital microfluidic chips (DMCs) have shown huge potential for biochemical analysis applications due to their excellent droplet manipulation capabilities. The driving force is a critical factor for characterizing and optimizing the performance of droplet manipulation. Conducting numerical analysis of the driving force is essential for DMC design, as it helps optimize the structural parameters.

Model-free parameters derived from intravoxel inherent motion combined with tumor aggressiveness indicators in predicting 5-year treatment outcome in NPC.

Purpose: To evaluate the value of model-free parameters (virtual magnetic resonance elastography [vMRE] and signature index [S-index]) and tumor aggressiveness indicators (contralateral pharyngeal recess invasion [CPRI] and tumor growth type [TGT]) in forecasting 5-year treatment outcomes in nasopharyngeal carcinoma (NPC).

Materials And Methods: A total of 106 patients were included in this study. Only two b-values were employed to calculate vMRE and S-index.

Distribution of , , and genes and determination of genetic relatedness of epidemic methicillin-resistant strains associated with bloodstream infections in southern China.

Introduction: Methicillin-resistant (MRSA) exhibits diverse genotypes with varying virulence and resistance profiles, particularly in the context of bloodstream infections (BSI). This study investigates the prevalence of the , , and genes among MRSA isolates from bloodstream infections in southern China and analyzes their genetic relatedness.

Methods: A polymerase chain reaction (PCR) assay was developed to detect the presence of the gene, which is associated with nasal colonization, immune evasion, and virulence, the mupirocin resistance gene , and the chlorhexidine tolerance gene in a total of 77 MRSA isolates.

Study of fluoroquinolones resistance in rifampicin-resistant tuberculosis patients in Beijing: Characteristics, trends, and treatment outcomes.

Background: China is a high-burden country for multidrug-resistant tuberculosis/rifampin-resistant tuberculosis (MDR/RR-TB). Fluoroquinolones (FQs) are key drugs for the treatment of patients with MDR/RR-TB. However, research on the resistance of FQs in Beijing is limited.

Pretreatment arterial spin labeling combined with radiological depth of invasion predicts treatment outcome in nonmetastatic NPC.

Background And Purpose: To investigate the value of arterial spin labeling (ASL) and radiological depth of invasion (rDOI) in predicting long-term treatment outcomes in nonmetastatic nasopharyngeal carcinoma (NPC).

Materials And Methods: A total of 113 patients with NPC were included and randomly divided into training (n = 81) and validation (n = 32) cohorts. Tumor blood flow (TBF) parameters derived from the ASL (TBF, TBF, and nTBF) were obtained.

Aperiodic intermittent dynamic event-triggered synchronization control for stochastic delayed multi-links complex networks.

In this work, the exponential synchronization issue of stochastic complex networks with time delays and time-varying multi-links (SCNTM) is discussed via a novel aperiodic intermittent dynamic event-triggered control (AIDE-TC). The AIDE-TC is designed by combining intermittent control with an exponential function and dynamic event-triggered control, aiming to minimize the number of the required triggers. Then, based on the proposed control strategy, the sufficient conditions for exponential synchronization in mean square of SCNTM are obtained by adopting graph theoretic approach and Lyapunov function method.

Integrated Cross-Scale Manipulation and Modulable Encapsulation of Cell-Laden Hydrogel for Constructing Tissue-Mimicking Microstructures.

Engineered microstructures that mimic in vivo tissues have demonstrated great potential for applications in regenerative medicine, drug screening, and cell behavior exploration. However, current methods for engineering microstructures that mimic the multi-extracellular matrix and multicellular features of natural tissues to realize tissue-mimicking microstructures in vitro remain insufficient. Here, we propose a versatile method for constructing tissue-mimicking heterogeneous microstructures by orderly integration of macroscopic hydrogel exchange, microscopic cell manipulation, and encapsulation modulation.

Nasal commensals reduce Staphylococcus aureus proliferation by restricting siderophore availability.

The human microbiome is critically associated with human health and disease. One aspect of this is that antibiotic-resistant opportunistic bacterial pathogens, such as methicillin-resistant Staphylococcus aureus, can reside within the nasal microbiota, which increases the risk of infection. Epidemiological studies of the nasal microbiome have revealed positive and negative correlations between non-pathogenic species and S.

Systematic literature review on reinforcement learning in non-communicable disease interventions.

There is evidence that reducing modifiable risk factors and strengthening medical and health interventions can reduce early mortality and economic losses from non-communicable diseases (NCDs). Machine learning (ML) algorithms have been successfully applied to preventing and controlling NCDs. Reinforcement learning (RL) is the most promising of these approaches because of its ability to dynamically adapt interventions to NCD disease progression and its commitment to achieving long-term intervention goals.

TPP-Based Microfluidic Chip Design and Fabrication Method for Optimized Nerve Cells Directed Growth.

Microfluidic chips offer high customizability and excellent biocompatibility, holding important promise for the precise control of biological growth at the microscale. However, the microfluidic chips employed in the studies of regulating cell growth are typically fabricated through 2D photolithography. This approach partially restricts the diversity of cell growth platform designs and manufacturing efficiency.

Antimicrobial and anti-biofilm activity of a thiazolidinone derivative against and .

() causes many infections with significant morbidity and mortality. can form biofilms, which can cause biofilm-associated diseases and increase resistance to many conventional antibiotics, resulting in chronic infection. It is critical to develop novel antibiotics against staphylococcal infections, particularly those that can kill cells embedded in biofilms.

Event-triggered hybrid impulsive control for synchronization of fractional-order multilayer signed networks under cyber attacks.

In this paper, we consider the exponential bipartite synchronization (EBS) problem of fractional-order multilayer signed networks with time-varying delays (FO-MSNT) under random cyber attacks. In contrast to the existing literature, the proposed hybrid event-triggered controller combines the advantages of feedback controller and impulsive controller, and the event-triggered condition is constructed by applying the network topology and the Lyapunov function of the subsystem, rather than the state function of the subsystem. Based on the Lyapunov-Razumikhin method and the graph theory, some sufficient conditions for achieving EBS of FO-MSNT under cyber attacks which are related to the topology of networks, the event-triggered parameters, the order of fractional derivative and the signal sent by the enemy are obtained.

Type-III-A structure of mycobacteria CRISPR-Csm complexes involving atypical crRNAs.

Tuberculosis (TB), a leading cause of mortality globally, is a chronic infectious disease caused by Mycobacterium tuberculosis that primarily infiltrates the lung. The mature crRNAs in M. tuberculosis transcribed from the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) locus exhibit an atypical structure featured with 5' and 3' repeat tags at both ends of the intact crRNA, in contrast to typical Type-III-A crRNAs that possess 5' repeat tags and partial crRNA sequences.

Changes in properties of human milk under different conditions of frozen storage.

Human milk is the best source of nutrition for infants. Lower freezing temperatures and faster freezing rates allow for better preservation of human milk. However, research on the freezing conditions of human milk is limited.

Analysis of preoperative computed tomography radiomics and clinical factors for predicting postsurgical recurrence of papillary thyroid carcinoma.

Background: Postsurgical recurrence is of great concern for papillary thyroid carcinoma (PTC). We aim to investigate the value of computed tomography (CT)-based radiomics features and conventional clinical factors in predicting the recurrence of PTC.

Methods: Two-hundred and eighty patients with PTC were retrospectively enrolled and divided into training and validation cohorts at a 6:4 ratio.

ZmELF3.1 integrates the RA2-TSH4 module to repress maize tassel branching.

Tassel branch number (TBN) is a key agronomic trait for adapting to high-density planting and grain yield in maize. However, the molecular regulatory mechanisms underlying tassel branching are still largely unknown. Here, we used molecular and genetic studies together to show that ZmELF3.

Psychodynamic-based virtual reality cognitive training system with personalized emotional arousal elements for mild cognitive impairment patients.

Background And Objective: Mild cognitive impairment (MCI) is a serious threat to the physical health and quality of life of the elderly, as well as a heavy burden on families and society. The current computer-based rehabilitation training ignores the role of emotions in cognitive impairment rehabilitation, making it difficult to improve patient engagement and efficiency. To address this, a psychodynamics-based cognitive rehabilitation training method with personalized emotional arousal elements was proposed using virtual reality technology.

Histogram analysis of quantitative parameters from synthetic MRI: correlations with prognostic factors in nasopharyngeal carcinoma.

Objectives: To evaluate the correlation between histogram parameters derived from synthetic magnetic resonance imaging (SyMRI) and prognostically relevant factors in nasopharyngeal carcinoma (NPC).

Methods: Fifty-nine consecutive NPC patients were prospectively enrolled. Quantitative parameters (T1, T2, and proton density (PD)) were obtained by outlining the three-dimensional volume of interest (VOI) of all lesions.

Pretreatment synthetic magnetic resonance imaging predicts disease progression in nonmetastatic nasopharyngeal carcinoma after intensity modulation radiation therapy.

Background: To investigate the potential of synthetic MRI (SyMRI) in the prognostic assessment of patients with nonmetastatic nasopharyngeal carcinoma (NPC), and the predictive value when combined with diffusion-weighted imaging (DWI) as well as clinical factors.

Methods: Fifty-three NPC patients who underwent SyMRI were prospectively included. 10th Percentile, Mean, Kurtosis, and Skewness of T1, T2, and PD maps and ADC value were obtained from the primary tumor.

Dynamics of a within-host drug resistance model with impulsive state feedback control.

Bacterial resistance poses a major hazard to human health, and is caused by the misuse and overuse of antibiotics. Thus, it is imperative to investigate the optimal dosing strategy to improve the treatment effect. In this study, a mathematical model of antibiotic-induced resistance is presented to improve the antibiotic effectiveness.

Histogram analysis of synthetic magnetic resonance imaging: Correlations with histopathological factors in head and neck squamous cell carcinoma.

Purpose: To analyse the association between histogram parameters derived from synthetic MRI (SyMRI) and different histopathological factors in head and neck squamous cell carcinoma (HNSCC).

Method: Sixty-one patients with histologically proven primary HNSCC were prospectively enrolled. The correlations between histogram parameters of SyMRI (T1, T2 and proton density (PD) maps) and histopathological factors were analysed using Spearman analysis.

The utility of texture analysis based on quantitative synthetic magnetic resonance imaging in nasopharyngeal carcinoma: a preliminary study.

Background: Magnetic resonance imaging (MRI) is commonly used for the diagnosis of nasopharyngeal carcinoma (NPC) and occipital clivus (OC) invasion, but a proportion of lesions may be missed using non-enhanced MRI. The purpose of this study is to investigate the diagnostic performance of synthetic magnetic resonance imaging (SyMRI) in differentiating NPC from nasopharyngeal hyperplasia (NPH), as well as evaluating OC invasion.

Methods: Fifty-nine patients with NPC and 48 volunteers who underwent SyMRI examination were prospectively enrolled.

DHA-enriched phosphatidylserine alleviates high fat diet-induced jejunum injury in mice by modulating gut microbiota.

A long-term high-fat diet (HFD) is one of the high-risk factors for intestinal barrier damage. Docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) has multiple biological activities, while its protective effect on HFD-caused jejunum injury remains unknown. Thus, the present study investigated the protective effect of DHA-PS on HFD-induced jejunum injury in mice.