Planted Citrus Regulates the Community and Networks of -Harboring Bacteria to Drive Phosphorus Availability Between Karst and Non-Karst Soils.

The phosphorus (P) availability in soils is influenced by microbes, particularly those containing the gene responsible for phosphate solubilization. The present study investigated the community structure, diversity, and co-occurrence networks of -harboring bacteria in karst and non-karst citrus orchard soils across a planting duration gradient, natural forests, and abandoned land, as well as the soil total P (TP) and available P (AP) contents and enzyme activities. The soil AP contents were lower in the karst regions than in the non-karst regions, while the soil organic carbon (C; SOC), exchangeable calcium, and microbial biomass nitrogen (N) contents; alkaline phosphatase (ALP) and β-Glucuronidase activities; and pH had the opposite trends.

Metagenome-Assembled Genomes of Pig Fecal Samples in Nine European Countries: Insights into Antibiotic Resistance Genes and Viruses.

Gut microbiota plays a crucial role in the health and productivity of pigs. However, the spread of antibiotic resistance genes (ARGs) and viruses within the pig intestinal microbiota poses significant threats to animal and public health. This study utilized 181 pig samples from nine European countries and employed metagenomic assembly methods to investigate the dynamics and distribution of ARGs and viruses within the pig intestinal microbiota, aiming to observing their associations with potential bacterial hosts.

Fano and Electromagnetically Induced Transparency Resonances in Dual Side-Coupled Photonic Crystal Nanobeam Cavities.

We propose two types of structures to achieve the control of Fano and electromagnetically induced transparency (EIT) line shapes, in which dual one-dimensional (1D) photonic crystal nanobeam cavities (PCNCs) are side-coupled to a bus waveguide with different gaps. For the proposed type Ⅰ and type Ⅱ systems, the phase differences between the nanobeam periodic structures of the two cavities are and 0, respectively. The whole structures are theoretically analyzed via the coupled mode theory and numerically demonstrated using the three-dimensional finite-difference time-domain (3D FDTD) method.

Size Effect on Shear Behaviors of 3D-Printed Soft Rock-like Materials Under Different Shear Velocities.

The shear failure of rock masses is one of the primary causes of underground engineering instability. The shear mechanical behavior of rocks at different sizes is of great significance for studying the shear failure pattern of engineering rock masses. However, due to the presence of various joints and defects in natural rocks, the obtained rock specimens exhibit significant discreteness, making it difficult to customize specimen sizes for size effect studies.

The Investigation of Graphene Oxide-Enhanced Hybrid Slurry Preparation and Its Polishing Characteristic on CVD Single Crystal Diamond.

As an environment-friendly material, graphene oxide nanosheet can effectively improve the polishing surface quality of single crystal diamond workpieces. However, the lubricating and chemical effects of graphene oxide nanosheets have an uncertain impact on the polishing material removal rate. In this paper, the graphene oxide-enhanced hybrid slurry was prepared with good stability.

Integrated Transcriptomic, Proteomic, and Metabolomic Analyses Revealed Molecular Mechanism for Salt Resistance in Soybean ( L.) Seedlings.

Salt stress poses a significant challenge to plant growth and restricts agricultural development. To delve into the intricate mechanisms involved in soybean's response to salt stress and find targets to improve the salt resistance of soybean, this study integrated transcriptomic, proteomic, and metabolomic analyses to explore the regulatory networks involved in soybean salt tolerance. Transcriptomic analysis revealed significant changes in transcription factors, hormone-related groups, and calcium ion signaling.

Alterations in the Microbiomes and Metabolic Profiles of the Ileal Between the Hu Sheep and East Friesian Sheep.

The East Friesian sheep is a dairy breed known for its high fertility and high milk production and is currently one of the best dairy sheep breeds in the world. This breed is known to have a poor disease-resistant phenotype compared to Hu sheep. Gut microbiota and metabolites play a role in host disease resistance.

Maresin-like 1 Ameliorates Neuropathology of Alzheimer's Disease in Brains of a Transgenic Mouse Model.

(1) Background: Impeded resolution of inflammation contributes substantially to the pathogenesis of Alzheimer's disease (AD); consequently, resolving inflammation is pivotal to the amelioration of AD pathology. This can potentially be achieved by the treatment with specialized pro-resolving lipid mediators (SPMs), which should resolve neuroinflammation in brains. (2) Methods: Here, we report the histological effects of long-term treatment with an SPM, maresin-like 1 (MarL1), on AD pathogenesis in a transgenic 5xFAD mouse model.

IL-6R Inhibitors and Gastrointestinal Perforations: A Pharmacovigilance Study and a Predicting Nomogram.

IL-6R inhibitors are widely used in many inflammation-related diseases, especially so during the COVID-19 pandemic. However, their relationship with gastrointestinal perforations (GIPs) has been reported more and more. We comprehensively analyzed IL-6R inhibitors in association with GIPs from the United States FDA Adverse Event Reporting System (FAERS).

Relationship Between Ethnic Essentialism and Psychological Compatibility: Roles of Ethnic Identity and Self-Construal.

We examined the impact of ethnic essentialism on psychological compatibility among minority and Han Chinese college students and investigated the roles of ethnic identity and self-construal. A moderated mediator analysis was used and a multigroup comparison of the moderated mediator model across ethnic groups was conducted. The results indicate that ethnic essentialism significantly and negatively predicts psychological compatibility.

Mental Fatigue and Sports Performance of Athletes: Theoretical Explanation, Influencing Factors, and Intervention Methods.

Mental fatigue is an important factor affecting athletes' performance. Explaining the effects of mental fatigue on sports performance from a theoretical point of view can help us deeply understand the interconnection between mental fatigue and sports performance and conduct effective interventions based on this. Combining the relevant literature in China and abroad reveals that the current academic theories on the mechanism of sports fatigue include motivational control theory, underload theory, neural waste disposal hypothesis, and resource depletion theory.

Comparison of Vendor-Pretrained and Custom-Trained Deep Learning Segmentation Models for Head-and-Neck, Breast, and Prostate Cancers.

Background/objectives: We assessed the influence of local patients and clinical characteristics on the performance of commercial deep learning (DL) segmentation models for head-and-neck (HN), breast, and prostate cancers.

Methods: Clinical computed tomography (CT) scans and clinically approved contours of 210 patients (53 HN, 49 left breast, 55 right breast, and 53 prostate cancer) were used to train and validate segmentation models integrated within a vendor-supplied DL training toolkit and to assess the performance of both vendor-pretrained and custom-trained models. Four custom models (HN, left breast, right breast, and prostate) were trained and validated with 30 (training)/5 (validation) HN, 34/5 left breast, 39/5 right breast, and 30/5 prostate patients to auto-segment a total of 24 organs at risk (OARs).

The Effect of Salt Reduction on the Microbial Community Structure and Metabolite Composition of Cheddar Cheese.

As consumer demand for low-salt diets increases, the development of low-salt cheese has emerged as a prevailing trend. To gain a deeper insight into the effects of salt reduction on cheddar cheese, this study used cheddar cheese with a 2.0% salt concentration (full salt, FS) as the standard control, exploring the differences in quality and composition between cheddar cheese with a 1.

Determination of Bioactive Components in Chrysanthemum Tea (Gongju) Using Hyperspectral Imaging Technique and Chemometrics.

The bioactive components of chrysanthemum tea are an essential indicator in evaluating its nutritive and commercial values. Combining hyperspectral imaging (HSI) with key wavelength selection and pattern recognition methods, this study developed a novel approach to estimating the content of bioactive components in chrysanthemums, including the total flavonoids (TFs) and chlorogenic acids (TCAs). To determine the informative wavelengths of hyperspectral images, we introduced a variable similarity regularization term into particle swarm optimization (denoted as VSPSO), which can focus on improving the combinatorial performance of key wavelengths and filtering out the features with higher collinearity simultaneously.

Comparison of Interactions Between Soy Protein Isolate and Three Folate Molecules: Effect on the Stabilization, Degradation, and Oxidization of Folates and Protein.

This study selected three approved folate sources-folic acid (FA), L-5-methyltetrahydrofolate (MTFA), and calcium 5-methyltetrahydrofolate (CMTFA)-to explore their interaction mechanisms with soy protein isolate (SPI) through spectrofluorometric analysis and molecular docking simulations. We investigated how these interactions influence the structural and physicochemical stability of folates and SPI. Three folates spontaneously bound to SPI, forming complexes, resulting in a decrease of approximately 30 kJ·mol in Gibbs free energy and an association constant (K) of 10 L·mol.

Quantitative Trait Loci Mappings for the Sulfur Utilization Efficiency-Related Traits at the Seedling Stage of Wheat.

Background: Sulfur (S) is a vital element for the normal growth and development of plants, performing crucial biological functions in various life processes.

Methods: This study investigated thirteen S utilization efficiency (SUE)-related traits at the seedling stage of wheat using a recombinant inbred line (RIL) population. The quantitative trait loci (QTLs) were mapped by genetic mapping.

Effect of IGF1 on Myogenic Proliferation and Differentiation of Bovine Skeletal Muscle Satellite Cells Through PI3K/AKT Signaling Pathway.

: Cultivated meat, an alternative to conventional meat, has substantial potential for alleviating environmental and ethical concerns. This method of manufacturing meat involves the isolation of skeletal muscle satellite cells (SMSCs) from donor animals, after which they proliferate in vitro and differentiate into primitive muscle fibers. The aim of this research was to evaluate how the insulin-like growth factor 1 (IGF1) gene regulates the myogenic differentiation of bovine skeletal muscle satellite cells (bSMSCs).

The Role of Gut Microbiome in Irritable Bowel Syndrome: Implications for Clinical Therapeutics.

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID) characterized by chronic or recurrent gastrointestinal symptoms without organic changes, and it is also a common disorder of gut-brain interaction (DGBIs).. The symptoms of IBS not only affect the quality of life for individual patients but also place a significant burden on global healthcare systems.

Isolation of Plasma Extracellular Vesicles for High-Depth Analysis of Proteomic Biomarkers in Metastatic Castration-Resistant Prostate Cancer Patients.

: Prostate cancer treatment has been revolutionized by targeted therapies, including PARP inhibitors, checkpoint immunotherapies, and PSMA-targeted radiotherapies. Despite such advancements, accurate patient stratification remains a challenge, with current methods relying on genomic markers, tissue staining, and imaging. Extracellular vesicle (EV)-derived proteins offer a novel non-invasive alternative for biomarker discovery, holding promise for improving treatment precision.

Vanillin Has Potent Antibacterial, Antioxidant, and Anti-Inflammatory Activities In Vitro and in Mouse Colitis Induced by Multidrug-Resistant .

A large number of cases of infectious colitis caused by multidrug-resistant (MDR) bacteria, such as , can result in colon damage and severe inflammation. Vanilla, a widely utilized flavor and fragrance compound, is extensively used in various food. However, the effect of vanilla on MDR -induced infectious colitis has received less attention.

Insights into the Molecular Mechanisms of Purine Compounds Synergistically Inducing Larval Settlement in Using Multi-Group Comparative Transcriptomic Analysis.

Most benthic marine invertebrates exhibit a characteristic biphasic life cycle, consisting of a planktonic larval stage followed by a benthic adult stage [...

PEAR1 Promotes Myoblast Proliferation Through Notch Signaling Pathway.

PEAR1, also known as platelet endothelial aggregation receptor 1, is known to play a crucial role in the migration and differentiation of muscle satellite cells (MuSCs). However, its specific effects on skeletal muscle development and regeneration require further exploration. In this study, the expression of PEAR1; the proliferation marker proteins of Pax7, CCNB1, and PCNA; and the key molecules of N1-ICD, N2-ICD, and Hes1 were all increased gradually during the process of C2C12 cell proliferation.

Effects of Supplementing Yeast Fermentation Products on Growth Performance, Colonic Metabolism, and Microbiota of Pigs Challenged with Typhimurium.

Yeast fermentation products (YFPs) are known to contain bioactive compounds, such as nutritional metabolites and cell wall polysaccharides (specifically glucan and mannan), which have been demonstrated to exert positive effects on the growth performance and immunity of livestock and poultry. However, the impact of YFPs on intestinal inflammation and microflora composition in pigs infected with typhimurium remains unclear. To investigate this, a total of 18 weaned pigs were divided into three treatment groups: a non-challenged control group (Con), a group challenged with typhimurium (ST), and a group challenged with typhimurium and supplemented with 0.

Transcriptome and Metabolome Insights into Key Genes Regulating Fat Deposition and Meat Quality in Pig Breeds.

Meat quality is a complex trait that exhibits significant variation across pig breeds, and the regulatory mechanisms governing pork meat quality are not fully elucidated. We compared the transcriptomics and metabolomics of the longissimus dorsi (LD) muscle between the Songliao Black Pig (SBP) and Large White × Landrace Pig (LWLDP) to investigate breed-specific differences in meat quality and underlying regulatory pathways. The results showed that SBP meat had a higher marbling score and backfat thickness, a richer color, a lower shear force, and reduced drip loss.

RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system.

Background: Neurodegenerative diseases (NDs) constitute a significant public health challenge, as they are increasingly contributing to global mortality and morbidity, particularly among the elderly population. Pathogenesis of NDs is intricate and multifactorial. Recently, post-transcriptional modifications (PTMs) of RNA, with a particular focus on mRNA methylation, have been gaining increasing attention.