Ecosystem multifunctionality enhancement by short-term nitrogen addition in semi-arid saline-alkaline grassland of northern China.

The vast area of saline-alkaline grasslands in the agro-pastoral ecotone of northern China has important production and ecological functions. Nitrogen (N) deposition changes the function and structure of vulnerable grasslands. However, the impacts of N deposition on ecosystem multifunctionality (EMF) remains unknown.

Single-Bacterium Diagnosis via Terahertz Near-Field Dielectric Nanoimaging.

Single-bacterium diagnostic methods with unprecedented precision and rapid turnaround times are promising tools for facilitating the transition from empirical treatment to personalized anti-infection treatment. Terahertz (THz) radiation, a cutting-edge technology for identifying pathogens, enables the label-free and non-destructive detection of intermolecular vibrational modes and bacterial dielectric properties. However, this individual dielectric property-based detection and the mismatched spatial resolution are limited for the single-bacterium identification of various species of pathogens.

Bacterial metabolites: Effects on the development of breast cancer and therapeutic efficacy (Review).

Evidence suggests that various gut metabolites significantly impact breast cancer (BC) and its treatment. However, the underlying mechanisms remain poorly understood and require further investigation. In the present study, the current literature was reviewed to evaluate the roles of microbial metabolites in the development of BC and its response to treatment.

STAT3-orchestrated gene expression signatures and tumor microenvironment in esophageal squamous cell carcinoma uncovered by single-cell sequencing.

Background: The progression of Esophageal Squamous Cell Carcinoma (ESCC) can be dissected with greater precision using multi-omics and single-cell RNA sequencing (scRNA-seq) compared to traditional methodologies. These advanced approaches enable a comprehensive understanding of cellular heterogeneity and molecular dynamics, offering higher resolution insights into cancer development. Moreover, analyzing transcription factor regulatory networks provides innovative avenues for identifying cancer biomarkers and therapeutic targets, driving new perspectives in cancer research.

Scimitar syndrome: A case report.

Scimitar syndrome is a rare vascular malformation characterized by partial or total abnormal flow of the right pulmonary vein into the inferior vena cava, located above or below the diaphragm. Scimitar syndrome is a rare disease has an incidence of approximately 1-3 per 100,000 live births. And it can be divided into infantile type and child/adult type.

Noncovalent interactions and properties of host-guest systems based on C82/C82Gd bucky-balls and symmetry broken nanohoop TP-[11]CPP.

The nanoscale host-guest interactions between a symmetry broken carbonaceous nanohoop TP-[11]cycloparaphenylene (TP-[11]CPP) and endohedral metallofullerene (EMF) C82Gd were explored by using density functional theory calculations. The geometry mutual-matching between TP-[11]CPP and C82Gd is perfect, and the two main configurations of TP-[11]CPP@C82Gd host-guest complexes could be formed spontaneously with high binding energies. Interestingly, the position of the Gd atom in the C82 cage can be adjusted by its external host molecule.

Integrated geophysical prospecting for deep ore detection in the Yongxin gold mining area, Heilongjiang, China.

Geophysical exploration techniques play a pivotal role in enhancing the accuracy of mineral prospecting predictions. However, relying solely on individual methods often introduces uncertainties. This study presents a case study from the Yongxin gold deposit, where we integrated audio-frequency magnetotelluric (AMT) methods with gravimetric surveying and high-resolution magnetic profiling to overcome this challenge.

Plant Biomass Allocation-Regulated Nitrogen and Phosphorus Addition Effects on Ecosystem Carbon Fluxes of a Lucerne ( ssp. ) Plantation in the Loess Plateau.

Nitrogen (N) and phosphorus (P) are key limiting factors for carbon (C) fluxes in artificial grasslands. The impact of their management on ecosystem C fluxes, including net ecosystem productivity (NEP), ecosystem respiration (ER), and gross ecosystem productivity (GEP) in the Loess Plateau is unclear. An experiment was conducted to study changes in these C fluxes with varying N (0, 5, 10, 15, and 20 g N m) and P (0 and 10 g P m) additions from 2022 to 2023 in a lucerne plantation.

Quantifying the relationship between cell proliferation and morphology during development of the face.

Morphogenesis requires highly coordinated, complex interactions between cellular processes: proliferation, migration, and apoptosis, along with physical tissue interactions. How these cellular and tissue dynamics drive morphogenesis remains elusive. Three dimensional (3D) microscopic imaging holds great promise, and generates elegant images, but generating even moderate through-put for quantified images is challenging for many reasons.

A novel injectable sodium alginate/chitosan/sulfated bacterial cellulose hydrogel as biohybrid artificial pancreas for real-time glycaemic regulation.

Type 1 diabetes mellitus (T1DM) are characterized by blood glucose elevation with pancreatic β cells deficiency. As a safe alternative to frequent subcutaneous insulin injection, pancreatic β cell transplantation provides a promising therapeutic option for blood glucose control in T1DM. However, pancreatic β cell transplantation faces intractable challenges of the poor viability and severe host immune rejection.

Application of Alfentanil Combined With Dexmedetomidine for Conscious Sedation of Patients During Transesophageal Echocardiography Examination.

Objectives: To investigate the efficacy and safety of combining alfentanil with dexmedetomidine for conscious sedation in outpatients undergoing transesophageal echocardiography (TEE).

Design: Prospective, randomized, double-blind clinical trial.

Setting: University-affiliated teaching hospital.

Polymerization of beneficial plant height QTLs to develop superior lines which can achieving hybrid performance levels.

Unlabelled: Heterosis, a key technology in modern commercial maize breeding, is limited by the narrow genetic base which hinders breeders from developing superior hybrid varieties. By integrating big data and functional genomics technologies, it becomes possible to create new super maize inbred lines that resemble hybrid varieties through the aggregation of multiple QTL parental advantage loci. In this study, we utilized a combination of resequencing and field selfing selection methods to develop three pyramiding QTL lines (PQLs) (PQL4, 6, and 7), each containing 15, 12, and 12 QTL loci respectively.

Fano resonances of coupled magnetic-dipole modes in a dielectric triplet for precise discrimination of deep-subwavelength microspheres.

Mie resonances in dielectric particles play a crucial role in light-matter interaction, characterized by strong multipolar optical responses and low dissipative losses. This study presents an innovative methodology for precise discrimination of the size and quantity of deep-subwavelength microspheres by leveraging Fano resonances in coupled magnetic-dipole (MD) modes of a CaTiO-ceramic-particle triplet. The multifaceted characteristics of coupled MD resonances exhibit high sensitivity and specificity in detecting minute changes in the ambient environment.

Growing Strong Polysaccharide-Derived Edible Straws with an Inherent Structural Binder via Biomanufacturing.

Developing food-related materials via biomanufacturing is expected to overcome the risks of microplastics and poly- and perfluoroalkyl substances posed by traditional materials such as plastics. Here, we report a biomanufacturing strategy to prepare high-performance polysaccharide-derived edible (PSE) straws. Starch is uniformly integrated into the three-dimensional cellulose nanonetwork produced by bacteria during biosynthesis.

Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2).

Introduction: Adolescent mental health problems represent a significant global health issue, particularly in low- and middle-income countries, such as the Republic of North Macedonia and the Republic of Moldova. Effective and scalable interventions are urgently needed to address these challenges.

Methods And Analysis: This protocol outlines a multicountry cluster randomised factorial trial, implemented according to the multiphase optimisation strategy (Phase 2), which evaluates the effectiveness and costs of three add-on components for the Parenting for Lifelong Health for Parents and Teens programme: adolescent mental health tools based on UNICEFs Helping Adolescents Thrive comics, adolescent peer support based on UNICEFs 'I Support My Friends' intervention and engagement booster designed to enhance attendance and programme completion through incentives.

Targeted mutation of / combined with the RUBY reporter enables an efficient two-line system for hybrid seed production in .

The recessive genic male sterility (RGMS) method has several benefits in hybrid seed production; however, it is seldom employed in industrial hybrid seed production owing to the difficulty of producing an ample number of pure male-sterile seeds. In this study, we present an efficient methodology for developing a two-line strategy to produce hybrid seed through targeted mutation of and in conjunction with the reporter in . In this method, male-sterile lines were successfully created directly from different elite rapeseed breeding lines through CRISPR/Cas9-mediated mutagenesis and enhanced -mediated transformation.

A new species of Tube-nosed Bat (Chiroptera: Vespertilionidae: ) from Qinghai-Tibet Plateau, China.

In 2018, an adult male of a small-sized Tube-nosed Bat (Chiroptera: Vespertilionidae: ) was captured at an arid cave located on the Qinghai-Tibet Plateau in Yushu City, Qinghai Province, China. Despite external morphological similarities with those of and , the individual in question displays explicit craniodental differences that distinguish it from either species. Morphological and morphometric evidence, coupled with phylogenetic analyses utilizing the mitochondrial gene, confirmed that it represents a distinct and still unknown species of , described herewith as sp.

NLRC3 Attenuates Antiviral Innate Immune Response by Targeting IRF7 in Grass Carp ().

belongs to the NOD-like receptor family and is recognized as a modulator of innate immune mechanisms. In this study, we firstly report that () acts as a negative regulator in the antiviral immune response. is ubiquitously expressed across tested tissues, displaying particularly high expression in the intestine, spleen, gill and kidney.

Targeting p21-Positive Senescent Chondrocytes via IL-6R/JAK2 Inhibition to Alleviate Osteoarthritis.

Osteoarthritis (OA) is an age-related degenerative joint disease, prominently influenced by the pro-inflammatory cytokine interleukin-6 (IL-6). Although elevated IL-6 levels in joint fluid are well-documented, the uneven cartilage degeneration observed in knee OA patients suggests additional underlying mechanisms. This study investigates the role of interleukin-6 receptor (IL-6R) in mediating IL-6 signaling and its contribution to OA progression.

Metabolic-Immune Suppression Mediated by the SIRT1-CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma.

Metabolic reprogramming of tumor cells dynamically reshapes the distribution of nutrients and signals in the tumor microenvironment (TME), affecting intercellular interactions and resulting in metabolic immune suppression. Increased glucose uptake and metabolism are characteristic of many tumors. Meanwhile, the progression of colorectal carcinoma (CRC) relies on lipid metabolism.

C-reactive protein as a possible indicator of PTSD prognosis and comorbid anhedonia.

Posttraumatic stress disorder (PTSD) is often chronic, which is costly to the individual and society. Easy-to-measure prognostic indicators can help to ensure that those with the greatest symptoms receive treatment. Inflammatory biomarkers may precede and predict depression chronicity and worsening, as well as PTSD.

Unraveling the impact of PFOA toxicity on Zostera marina using a multi-omics approach: Insights from growth, physiological, transcriptomic, and metabolomic signatures.

Perfluorooctanoic acid (PFOA), an anthropogenic organic pollutant known for its persistence, resistance to degradation, and toxicity, has raised significant concerns about its potential ecological impacts. Zostera marina, a common submerged seagrass species in temperate offshore areas, is highly vulnerable to pollutant stressors. However, the impact of PFOA on Z.

Open-ended urethral catheters reduce catheter obstruction after hypospadias repair.

Backgrounds: Urethral catheter obstruction is a notable issue that pediatric patients with hypospadias may encounter in the early postoperative period. This retrospective study aims to assess the efficacy of open-ended urethral catheters with 2 side holes in mitigating catheter obstruction in pediatric patients following hypospadias repair.

Materials And Methods: The clinical data of pediatric patients who underwent hypospadias repair surgery from January 2021 to October 2023 were retrospectively collected.

The interplay of transcriptional regulator SREBP1 with AMPK promotes lipid biosynthesis in Mucor circinelloides WJ11.

SREBP1 is a transcription factor that influences lipogenesis by regulating key genes associated with lipid biosynthesis, while AMPK, modulates lipid metabolism by regulating acetyl-CoA carboxylase. The exact role of these metabolic regulators in oleaginous microbes remains unclear. This study identified and manipulated the genes encoding SREBP1 (sre1) and α1 subunit of AMPK (ampk-α1) in Mucor circinelloides WJ11.