Amodiaquine ameliorates stress-induced premature cellular senescence via promoting SIRT1-mediated HR repair.

DNA damage is considered to be a potentially unifying driver of ageing, and the stalling of DNA damage repair accelerates the cellular senescence. However, augmenting DNA repair has remained a great challenge due to the intricate repair mechanisms specific for multiple types of lesions. Herein, we miniaturized our modified detecting system for homologous recombination (HR) into a 96-well-based platform and performed a high-throughput chemical screen for FDA-approved drugs.

Supergroup algorithm and knowledge graph construction in museum digital display platform.

In response to the problems of low entity recognition accuracy, low user satisfaction, and weak interactivity in the construction of knowledge graph for digital display of museum cultural relics, this article studied the application of supergroup algorithms and knowledge graph construction in museum digital display platforms to solve the existing problems. By utilizing the K-means algorithm in the supergroup algorithm to conduct a survey of visitors to Museum A and analyze the behavior of 180 selected visitors, the display effect and audience satisfaction can be improved. Various knowledge graph technologies were utilized to construct a knowledge graph of museum cultural relics.

The efficacy and safety of a novel PD-1/CTLA-4 bispecific antibody cadonilimab (AK104) in advanced non-small cell lung cancer: A multicenter retrospective observational study.

Background: For patients with advanced non-small cell lung cancer (NSCLC) who have received frontline immunochemotherapy, subsequent treatment options are limited. As the first dual programmed cell death-1 (PD-1)/cytotoxic T lymphocyte-associated antigen-4 bispecific antibody approved globally, cadonilimab demonstrated potential antitumor activity in advanced NSCLC patients resistant to anti-PD-1/PD-L1 antibodies.

Methods: We retrospectively collected efficacy and safety data from advanced NSCLC patients treated with cadonilimab-based regimens in later therapy lines.

A simple spectrogram model for high-accuracy spectral calibration of VIPA spectrometers.

The virtually imaged phased array (VIPA) spectrometer uses the orthogonal dispersion method and has the advantages of compact structure, high spectral resolution, and wide wavelength coverage. It has been widely used in different fields. However, due to the non-linear dispersion of the VIPA etalon and the cross-dispersion structure of the VIPA spectrometer, simple and high-accuracy wavelength calibration remains a challenge.

Treatment of acute pharyngitis in rats with season tea decoctions from traditional Chinese medicine through a synergistic and subtle regulation of ARNTL and BHLHE40.

Ethnopharmacological Relevance: While the seasonal variations in the human immune function and many infectious diseases are well-known, to develop therapeutic strategies regarding such seasonality is quite challenging. However, some traditional medical practices have already taken the seasonality into account, such as the "Season Tea" (ST) decoctions investigated in the present study.

Aim Of The Study: We present a study of the ST decoctions from traditional Chinese medicine, which include four formulae designed for the four seasons, aiming to investigate their pharmacological commonality and distinction.

Formation of Nitrosamines from the Heterogeneous Reaction of Nitrous Acid and Organic Amines in Indoor Environments.

Carcinogenic nitrosamines have been widely studied due to their risk to human health. However, the universality and evolutionary processes of their generation, particularly concerning their secondary sources, remain unclear at present. We demonstrated through laboratory flow tube experiments that corresponding nitrosamines were generated from heterogeneous reactions of nitrous acid (HONO) with five structurally diverse amines commonly found indoors, including diphenylamine (DPhA), dibenzylamine (DBzA), dioctylamine (DOtA), -(1,3-dimethylbutyl)-'-phenyl--phenylenediamine (6PPD), and -phenyl-1-naphthylamine (PANA).

Distinct roles of the two BRCA2 DNA binding domains in DNA damage repair and replication fork preservation.

Homologous recombination (HR) is a highly conserved tool for the removal of DNA double-strand breaks (DSBs) and the preservation of stalled and damaged DNA replication forks. Successful completion of HR requires the tumor suppressor BRCA2. Germline mutations in BRCA2 lead to familial breast, ovarian, and other cancers, underscoring the importance of this protein for maintaining genome stability.

Effects of coordinated regulation of water, nitrogen, and biochar on the yield and soil greenhouse gas emission intensity of greenhouse tomatoes.

Regulating the coupled relationship among water, nitrogen, and biochar is an effective strategy for increasing production and reducing emissions in greenhouse agriculture. However, a comprehensive evaluation model remains lacking. Toward this end, we aimed to evaluate the emission patterns of greenhouse gases and greenhouse tomato yield during the spring and autumn cultivation seasons as influenced by irrigation water use efficiency, nitrogen fertilizer partial productivity, and soil organic carbon (SOC).

Metal-Organic Frameworks for Sustainable Crop Disease Management: Current Applications, Mechanistic Insights, and Future Challenges.

Efficient management of crop diseases and yield enhancement are essential for addressing the increasing food demands due to global population growth. Metal-organic frameworks (MOFs), which have rapidly evolved throughout the 21st century, are notable for their vast surface area, porosity, and adaptability, establishing them as highly effective vehicles for controlled drug delivery. This review methodically categorizes common MOFs employed in crop disease management and details their effectiveness against various pathogens.

Switchable Topologically Chiral [2]Catenane as Multiple Resonance Thermally Activated Delayed Fluorescence Emitter for Efficient Circularly Polarized Electroluminescence.

Aiming at the fabrication of circularly polarized organic light-emitting diodes (CP-OLEDs) with high dissymmetry factors (g) and color purity through the employment of novel chiral source, topologically chiral [2]catenanes were first utilized as the key chiral skeleton to construct novel multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters. Impressively, the efficient chirality induction and unique switchable feature of topologically chiral [2]catenane not only lead to a high |g| value up to 1.6×10 but also facilitate in situ dynamic switching of the full-width at half-maximum (FWHM) and circularly polarized luminescence (CPL).

An asymptomatic geminivirus activates autophagy and enhances plant defenses against diverse pathogens.

Plant viral diseases cause great losses in agricultural production. Virus cross-protection is a strategy in which a mild virus is employed to shield plants against subsequent infections by severe viral strains. However, this approach is restricted to protection against the same viruses.

An Aquatic Autonomic Nervous System.

Reproducing human nervous systems with endogenous mechanisms has attracted increasing attention, driven by its great potential in streamlining the neuro-electronic interfaces with bilateral signaling. Here, an artificial aquatic autonomic nervous system (ANS) with switchable excitatory/inhibitory characteristics and acetylcholine (ACh)-mediated plasticity is reported based on the newly emerged organic photoelectrochemical transistor (OPECT). Under the modulation of spatial light and ACh, the system exhibits an immediate switch between excitation and inhibition, and many pulse patterns as well as advanced ANS functions are mimicked.