Genistein Implications in Radiotherapy: Kill Two Birds with One Stone.

More than 70% of cancer patients receive radiotherapy during their treatment, with consequent various side effects on normal cells due to high ionizing radiation doses despite tumor shrinkage. To date, many radioprotectors and radiosensitizers have been investigated in preclinical studies, but their use has been hampered by the high toxicity to normal cells or poor tumor radiosensitization effects. Genistein is a naturally occurring isoflavone found in soy products.

Systemic lupus erythematosus and male reproductive health: A systematic review and meta-analysis.

Objective: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect various organs. Male SLE patients often face reproductive health challenges, but research on male sexual and reproductive health in SLE remains limited. This systematic review and meta-analysis aimed to explore the effects of SLE and its related factors on male sexual function and reproductive health.

RNA binding protein ALYREF regulates ferroptosis to facilitate LUAD growth and metastasis via promoting SLC7A11 mRNA stability.

Ferroptosis is of great significance in carcinogenesis as it interconnects with a multiplicity of biological processes. Meanwhile, its function and regulatory role in lung cancer remains ambiguous. In this study, we discovered by WB and IHC that ALYREF has a higher expression in lung adenocarcinoma (LUAD) tissues compared with normal ones.

Anticoagulant Activity of the Polysaccharide Fromgonad of Abalone Ino: The Role of Conjugate Protein.

Few studies are concerned with the effect of the conjugat protein on the bioactivities of the abalone gonad polysaccharide (AGP). In this study, a series of treatments, including raw material (female and male) defatting, extraction temperature (25-121 °C), proteolysis, ultrafiltration, and ethanol precipitation, was conducted to investigate the role of the conjugate protein on AGP anticoagulant activity. All AGP extracts significantly prolonged activated partial thromboplastin time (APTT) and thrombin time (TT).

Multifunctional hydrogel scaffolds based on polysaccharides and polymer matrices promote bone repair: A review.

With the advancement of medical technology, the utilization of bioactive materials to promote bone repair has emerged as a significant research area. Hydrogels, as biomaterials, play a crucial role in bone tissue engineering. These hydrogels exhibit high biocompatibility, providing in vivo ecological conditions conducive to cell survival, and offer substantial advantages in facilitating bone repair.

Fatal familial insomnia: A new case description with response to thoracic sympathetic nerve thermocoagulation and stellate ganglion block.

Fatal familial insomnia (FFI) is a rare autosomal dominant neurodegenerative disorder characterized by rapidly progressive dementia, severe sleep disturbances, and autonomic dysfunction. The clinical manifestations of FFI can exhibit substantial variations, making it crucial to rule out other conditions, such as autoimmune encephalitis and Creutzfeldt-Jakob disease, during early diagnosis. In this study, we describe the case of a 58-year-old man who experienced persistent insomnia, autonomic symptoms, gait instability, and rapidly progressive dementia.

Cellulose nanofibers reinforced carboxylated nitrile butadiene rubber coatings for improved corrosion protection of mild steel.

The development of an efficient coating with comprehensive antimicrobial and anticorrosion properties for metals is crucial. The present study used a one-pot strategy to fabricate a high-performance nanocomposite coating of carboxylated nitrile butadiene rubber/cellulose nanofibers/zinc oxide (XNBR/CNF-ZnO), demonstrating excellent potential for application in the protection against metal corrosion. Eco-friendly CNF-ZnO nanomaterials, prepared using the in-situ generation method, were used as reinforcing fillers, while XNBR was used as the matrix material.

AGEING RESEARCH REVIEWS (ARR-D-24-01334R1) Metabolic dysfunction contributes to mood disorders after traumatic brain injury.

Traumatic brain injury (TBI) presents significant risks concerning mortality and morbidity. Individuals who suffer from TBI may exhibit mood disorders, including anxiety and depression. Both preclinical and clinical research have established correlations between TBI and disturbances in the metabolism of amino acids, lipids, iron, zinc, and copper, which are implicated in the emergence of mood disorders post-TBI.

Literature review analysis of aortitis induced by granulocyte-colony stimulating factor.

Background: Recombinant human granulocyte-colony stimulating factors (G-CSF)-induced aortitis is a rare but particularly serious adverse event, commonly seen in cancer patients undergoing chemotherapy. The aim of this article is to clarify the clinical characteristics of G-CSF- induced aortitis and provide effective references for clinical diagnosis and intervention.

Methods: Case reports of adverse reactions of aortitis induced by G-CSF were collected from the relevant databases.

Tumor-derived CCL15 regulates RNA mA methylation in cancer-associated fibroblasts to promote hepatocellular carcinoma growth.

Hepatocellular carcinoma (HCC) is a lethal malignancy characterized by rapid growth. The interaction between tumor cells and cancer-associated fibroblasts (CAFs) significantly influences HCC progression. CCL15, a CC chemokine family member, is predominantly expressed in HCC and strongly correlates with tumor size, indicating its critical role in HCC growth.

[Construction of a diagnostic model and scoring system for central precocious puberty in girls, with external validation].

Objectives: To establish an efficient and clinically applicable predictive model and scoring system for central precocious puberty (CPP) in girls, and to develop a diagnostic prediction application.

Methods: A total of 342 girls aged 4 to 9 years with precocious puberty were included, comprising 216 cases of CPP and 126 cases of isolated premature thelarche. Lasso regression was used to screen for predictive factors, and logistic regression was employed to establish the predictive model.

[Spatiotemporal Patterns and Driving Forces Analysis of Ecological Carbon Sink from 2001 to 2022 in Qinling-Daba Mountains,China].

The Qinling-Daba Mountain area, an essential ecological conservation zone in China, occupies a pivotal position in the pursuit of carbon neutrality. Using diverse data sources, including temperature, precipitation, solar radiation, and the Normalized Difference Vegetation Index, we refined the CASA model by replacing model indicators. This enhanced model simulated the net primary productivity of vegetation in the Qinling-Daba Mountain area from 2001 to 2022.

Perovskite CsCuClxBr3- x Microcrystals: Band Structure, Photochemical Stability, and Photocatalytic Properties.

Although Pb-based metal halide perovskites (MHPs) have excellent photoelectric characteristics, their toxicity remains a limiting factor for their widespread application. In the paper, a series of CsCuClxBr3-x (x = 1, 2, 3) MHP microcrystals were developed and their hydrogen evolution performance in ethanol and HX (X = Cl, Br) was also studied. Among them, CsCuCl3 microcrystals exhibit high hydrogen evolution performance in both HX and ethanol, attributed to their longest average lifetime and suitable band structure.

Esketamine Provides Neuroprotection After Intracerebral Hemorrhage in Mice via the NTF3/PI3K/AKT Pathway.

Background: Esketamine (ESK), a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, modulates neurotransmitter signaling in the central nervous system. However, the specific mechanisms and therapeutic potential of ESK for intracerebral hemorrhage (ICH) remain unclear. This study aimed to investigate whether ESK promotes nerve repair and improves neurological outcomes in an experimental model of ICH.

A multimodal deep-learning model based on multichannel CT radiomics for predicting pathological grade of bladder cancer.

Objective: To construct a predictive model using deep-learning radiomics and clinical risk factors for assessing the preoperative histopathological grade of bladder cancer according to computed tomography (CT) images.

Methods: A retrospective analysis was conducted involving 201 bladder cancer patients with definite pathological grading results after surgical excision at the organization between January 2019 and June 2023. The cohort was classified into a test set of 81 cases and a training set of 120 cases.

Corrigendum: Advances in retinal imaging biomarkers for the diagnosis of cerebrovascular disease.

[This corrects the article DOI: 10.3389/fneur.2024.

MADS-box BSISTER transcription factors regulate stilbenes biosynthesis in grapes by directly binding to the promoter of STS48.

Stilbenes constitute a class of naturally occurring polyphenolic compounds that have been identified in a wide range of plants. In wine, stilbenes play crucial roles in humans, exhibiting anti-cancer, anti-inflammatory, antioxidant properties, and aiding in the prevention of cardiovascular diseases. Therefore, studies on the synthesis and regulatory mechanisms of styrene compounds in grapes are of great economic importance.

Effects of CYP2C19 and CYP2C9 polymorphisms on the efficacy and plasma concentration of lacosamide in pediatric patients with epilepsy in China.

Unlabelled: To evaluate the effects of cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms on the plasma concentrations, efficacy, and safety of lacosamide (LCM) among pediatric patients with epilepsy. This prospective study was conducted at two institutions. It included 215 pediatric patients with epilepsy who were under LCM.

Semi-coherent Interface and Vacancy Engineering for Constructing NiTe/FeTe/FeO/FF to Boost Electrochemical Overall Water Splitting.

Transition metal-based tellurides (TMTs) with excellent electrical conductivity are expected to be ideal electrocatalysts for overall water splitting. However, compared to transition metal sulfides and selenides, the reported applications of TMTs in overall water splitting are fewer. Herein, the NiTe/FeTe/FeO/FF carnation flower-like with a semi-coherent interface is successfully constructed to enhance the electrochemical overall water splitting performance.

Effects of anti-seizure medications on resting-state functional networks in juvenile myoclonic epilepsy: An EEG microstate analysis.

Objective: Juvenile myoclonic epilepsy (JME) is associated with large-scale brain network dysfunction. This study aims to investigate how anti-seizure medication (ASM) treatment alters resting-state functional networks in JME patients through resting-state EEG microstate analysis.

Methods: Ninety-six subjects participated in this study: 24 healthy controls (HC), 29 newly diagnosed JME patients who had not started ASMs therapy (JME-NM), and 43 JME patients on ASMs treatment with effective seizure control (JME-M).

Glutathione transferase VvGSTU60 is essential for proanthocyanidin accumulation and cooperates synergistically with MATE in grapes.

Proanthocyanidin, synthesized in the endoplasmic reticulum and stored in vacuoles, is key to grape and wine quality. Glutathione S-transferase (GST) plays a crucial role in proanthocyanidin accumulation. However, little is known about the mechanisms of GSTs in the process.

Regulation of hydrogen rich water on strawberry seedlings and root endophytic bacteria under salt stress.

Salt stress could lead to plant growth barriers and crop yield reduction. Strawberries are sensitive to salt stress, and improving salt tolerance is important for strawberry production. This study aimed to explore the potential of hydrogen-rich water (HRW) to enhance salt tolerance in strawberries.

The Efficacy of Anlotinib Plus Whole Brain Radiotherapy in Advanced Non-Small Cell Lung Cancer With Multiple Brain Metastases: A Retrospective Study.

Purpose: This study aimed to compare the efficacy of anlotinib plus whole-brain radiotherapy (WBRT) with that of WBRT alone in non-small cell lung cancer (NSCLC) patients with multiple brain metastases (BMs).

Methods: The clinical data of patients with NSCLC and multiple BMs who received WBRT between 2019 and 2022 were collected. The patients were assigned to anlotinib plus WBRT group and WBRT group according to the treatment used.

One-step hydrothermal synthesis of CQDs/TiO/NH-MIL-125 for efficient photocatalytic production of HO under visible light.

NH-MIL-125 and its derivatives are receiving more attention in various aspects of photocatalytic reactions, especially in the photocatalytic hydrogen peroxide (HO) production from water (HO) and oxygen (O), which is a promising and sustainable strategy. However, the generation of HO from NH-MIL-125 is far from satisfactory due to rapid photo-generated carriers recombination and poor surface electron transfer. In the work, the composite photocatalyst CQDs/TiO/NH-MIL-125 (C/T/NM) was designed for the first time by one-step hydrothermal method.