Noise-Aware Framework for Robust Visual Tracking.

Both siamese network and correlation filter (CF)-based trackers have exhibited superior performance by formulating tracking as a similarity measure problem, where a similarity map is learned by the correlation between a target template and a region of interest (ROI) with a cosine window. Nevertheless, this window function is usually fixed for various targets and not changed, undergoing significant noise variations during tracking, which easily makes model drift. In this article, we focus on the study of a noise-aware (NA) framework for robust visual tracking.

Chromosomal and molecular pathway alterations in the neuroendocrine carcinoma and adenocarcinoma components of gastric mixed neuroendocrine-nonneuroendocrine neoplasm.

Gastric mixed adenoneuroendocrine carcinoma (MANEC) is a clinically aggressive subtype of mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) with unclear clonal origin. In this study, we analyzed high-resolution copy number (CN) profiling data using the OncoScan CNV Assay in the neuroendocrine carcinoma (NEC) and adenocarcinoma components of eight MANECs. Some common CNVs, including the gain of CCNE1 (19q12) and the loss of FAT1 (4q35.

Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy.

Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (I) are used in situ to construct active sites in a nanocatalyst (TiO) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT).

Tibet plateau probiotic mitigates chromate toxicity in mice by alleviating oxidative stress in gut microbiota.

Heavy metal contamination in food endangers human health. Probiotics can protect animals and human against heavy metals, but the detoxification mechanism has not been fully clarified. Here, mice were supplemented with Pediococcus acidilactici strain BT36 isolated from Tibetan plateau yogurt, with strong antioxidant activity but no chromate reduction ability for 20 days to ensure gut colonization.

Increased carotid stiffness detected by ultrafast ultrasound imaging is associated with the Gensini score.

Aim: To test the ability of carotid stiffness evaluated by using ultrafast ultrasound imaging to indicate coronary atherosclerosis and its association with the severity of coronary artery disease (CAD).

Material And Methods: This cross-sectional study included 131 patients with CAD and 60 normal controls. Carotid intima-media thickness (cIMT) was measured by two-dimensional ultrasound.

Direct Measurement of Plant Cellulose Microfibril and Bundles in Native Cell Walls.

Plants use rigid cellulose together with non-cellulosic matrix polymers to build cell walls. Cellulose microfibrils comprise linear β(1,4)-glucan chains packed through inter- and intra-chain hydrogen-bonding networks and van der Waals forces. Due to its small size, the number of glucan chains and their arrangement in a microfibril remains elusive.

Using the Decomposition-Based Multi-Objective Evolutionary Algorithm with Adaptive Neighborhood Sizes and Dynamic Constraint Strategies to Retrieve Atmospheric Ducts.

The traditional method of retrieving atmospheric ducts is to use the special sensor of weather balloons or rocket soundings to obtain information intelligently, and it is very expensive. Today, with the development of technology, it is very convenient to retrieve the atmospheric ducts from Global Navigation Satellite System (GNSS) phase delay and propagation loss observation data, and then the GNSS receiver on the ground forms an automatic receiving sensor. This paper proposes a hybrid decomposition-based multi-objective evolutionary algorithm with adaptive neighborhood sizes (EN-MOEA/ACD-NS), which dynamically imposes some constraints on the objectives.

TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF‑7 cells.

Tamoxifen is widely used as a highly effective drug for treating estrogen‑receptor (ER) alpha‑positive breast cancer. However, tamoxifen resistance developed during cancer treatment remains a significant challenge. Tongue cancer resistance‑related protein1 (TCRP1), which is recognized as a novel drug target, is related to chemo‑resistance in human cancers, moreover, it is often overexpressed in various cancer cells, such as in lung cancer, breast cancer, and tongue cancer.

Alkaline aided thermophiles pretreatment of waste activated sludge to increase short chain fatty acids production: Microbial community evolution by alkaline on hydrolysis and fermentation.

Adding alkaline into an anaerobic waste activated sludge (WAS) fermentation with thermophilic bacteria pretreatment could efficiently improve short-chain fatty acids (SCFAs) accumulation to 3550 ± 120 mg COD/L. The acidification rate in combined test was 21.2%, while that was 15.

Weighted Gene Co-expression Network Analysis Identifies Critical Genes for the Production of Cellulase and Xylanase in .

Genes involved in cellular processes undergo environment-dependent co-regulation, but the co-expression patterns of fungal cellulase and xylanase-encoding genes remain unclear. Here, we identified two novel carbon sources, methylcellulose and 2-hydroxyethyl cellulose, which efficiently induced the secretion of cellulases and xylanases in . Comparative transcriptomic analyses identified carbon source-specific transcriptional patterns, mainly including major cellulase and xylanase-encoding genes, genes involved in glycolysis/gluconeogenesis and the tricarboxylic acid cycle, and genes encoding transcription factors, transporters and G protein-coupled receptors.

A novel self-supported structure of Ce-UiO-66/TNF in a redox electrolyte with high supercapacitive performance.

A novel self-supported structure of Ce-UiO-66/TNF was firstly synthesized by growing Ce-UiO-66 on a TNF substrate. This novel Ce-UiO-66/TNF material was proved to possess a high supercapacitive performance in the redox electrolyte of Fe(CN)/, and it was also the first study for Ce-UiO-66 material on the supercapacitor application. High specific capacitances of 6.

Anesthetic Management of Patients Undergoing Aortic Dissection Repair With Suspected Severe Acute Respiratory Syndrome COVID-19 Infection.

Severe acute respiratory syndrome coronavirus-2 is still active in Wuhan, China, and is spreading to the rest of the world. Recently, perioperative anesthetic management in patients with suspected or confirmed coronavirus-2 has been reported. However, little has been reported on the anesthetic management of patients undergoing aortic dissection repair in patients with suspected severe acute respiratory syndrome coronavirus-2 infection.

Characterization of subtypes and transmitted drug resistance strains of HIV among Beijing residents between 2001-2016.

Background: Beijing is a national and international hub potentially containing a broad diversity of HIV variants. Previous studies on molecular epidemiology of HIV in Beijing pooled together samples from residents and non-residents. Pooling residents and non-residents has potentially introduced bias and undermined a good assessment and the intervention among the autochthonous population.

Anesthetic Management of Patients with COVID 19 Infections during Emergency Procedures.

Objectives: The aim of the present study was to prevent cross-infection in the operating room during emergency procedures for patients with confirmed or suspected 2019 novel coronavirus (2019-nCoV) by following anesthesia management protocols, and to document clinical- and anesthesia-related characteristics of these patients.

Design: This was a retrospective, multicenter clinical study.

Setting: This study used a multicenter dataset from 4 hospitals in Wuhan, China.

LncRNA XIST interacts with miR-454 to inhibit cells proliferation, epithelial mesenchymal transition and induces apoptosis in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is a one of the subtypes of breast cancer which accounts for approximately 10-20% of all breast cancers. LncRNA XIST (XIST) is reported to be dysfunctional in numerous tumor types and is involved in the key pathways of cancer initiation, progression and metastasis. Thus, in the present study, we explored the detailed molecular mechanism of XIST in TNBC.

Bifunctional polyaniline electroconductive hydrogels with applications in supercapacitor and wearable strain sensors.

In this article, bifunctional polyaniline/polyacrylamide (PANI/PAAm) hydrogel is fabricated. The hydrogel has capacitive performance and can be used for monitoring human motions. The effect of PANI doped with two different acids on the properties of hydrogels was researched.

Efficacy and safety of modified endoscopic mucosal resection for rectal neuroendocrine tumors: a meta-analysis.

Purpose:  Rectal neuroendocrine tumors are rare with good prognosis. Several endoscopic methods such as endoscopic polypectomy, endoscopic submucosal dissection (ESD), endoscopic mucosal resection (EMR), and modified endoscopic mucosal resection (m-EMR) are used in the treatment of rectal neuroendocrine tumors. Although m-EMR is derived from traditional EMR, it has not been widely used in clinical practice.

Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation.

Intestinal fibrosis leading to strictures remains a significant clinical problem in inflammatory bowel diseases (IBD). The role of bacterial components in activating intestinal mesenchymal cells and driving fibrogenesis is largely unexplored. Tamoxifen-inducible α-SMA promoter Cre mice crossed with floxed MyD88 mice were subjected to chronic dextran sodium sulfate colitis.

Cell active and functionally-relevant small-molecule agonists of calcitonin receptor.

The natural calcitonin (CT) receptor and its peptide agonists are considered validated targets for drug discovery. A small molecule agonist, SUN-B8155, has previously been shown to efficiently activate cellular CTR. Herein, we report the synthesis of a series of compounds (S8155 1-9) derived from SUN-B8155, and investigate the structural-functional relationship, bias properties and their cellular activity profile.

Endothelial function and plasma matrix metalloproteinase-2 levels and their association with the size and elastic properties of the ascending aorta in first-degree relatives of bicuspid aortic valve patients.

Purpose: To explore endothelial function and plasma matrix metalloproteinase-2 levels and their association with the size and elastic properties of the ascending aorta in the first-degree relatives (FDRs) with tricuspid aortic valve (TAV) of individuals with bicuspid aortic valve (BAV).

Methods: Twenty-six patients with BAV without significant valvular dysfunction, 35 FDRs with TAV, and 29 matched healthy controls were analyzed. Two-dimensional echocardiography and high-resolution ultrasound were applied to evaluate the size and elasticity of the ascending aorta and the flow-mediated vasodilation (FMD) of the brachial artery in response to hyperemia.

Development of a lateral flow aptamer assay strip for facile identification of theranostic exosomes isolated from human lung carcinoma cells.

Exosomes are Extracellular Vesicles (EV) that own unique structural features and functions and have gradually become the hot research spot in recent years. The tumor-derived exosomes contain various types of useful biological information, and medical identification of exosomes relied on the specific characterization of membrane surface proteins. In this study, in order to rapidly identify non-small cell lung cancer (NSCLC)-derived exosomes, based on an aptamer against CD63 protein on exosome membrane, a low cost lateral flow aptamer assay (LFAA) test strip using nanogold particles as visualization probes was successfully developed for facile identification of A549 exosomes isolated from human lung carcinoma cells diluted from 6.

Synergistic Fire Hazard Effect of a Multifunctional Flame Retardant in Building Insulation Expandable Polystyrene through a Simple Surface-Coating Method.

This work reports a strategy based on γ-aminopropyltriethoxysilane (KH550) and graphene oxide (GO)-functionalized 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) to fabricate P-N-Si integrated flame retardant [KDOPO-modified GO (DGO)] through mild Mannich and Silanization reactions to overcome the challenge of single gas-phase fire retardancy of DOPO. DGO-based phenolic epoxy resin (DGO/PER) is manufactured and coated on the surface of expandable polystyrene (EPS) foam plates to achieve fire safety, which is used as the thermally insulating external wall in buildings and constructions. The DGO/PER paintcoat imparts high fire safety to the EPS foam plate, exhibiting a high limiting oxygen index value of 29%, and a UL-94 V-0 classification is achieved with only 300 μm of layer thickness compared with the DOPO/PER paintcoat.