Effect of Mn content on the corrosion behavior and biocompatibility of biodegradable Zn-Mn alloys.

Zinc-based alloys have attracted increasing attention as biodegradable metals by virtue of their excellent mechanical, degradable and biocompatible properties. By introducing different levels of manganese (0.1, 0.

Screening and Functional Characterization of Nanobodies Targeting the Transferrin Receptor.

The transferrin receptor (TfR1) mediates the cellular uptake of iron and other molecules, playing a vital role in hematology and tumor growth. Nanobodies(NBs) targeting TfR1 offer promising therapeutic potential due to their small size, high specificity and stability. However, rapid identification of effective nanobodies remains challenging.

The Epidemiological Analysis of Respiratory Virus Infections in Children in Hangzhou from 2019 to 2023.

To investigate the infection of children with respiratory tract infection in Hangzhou from 2019 to 2023, and to explore the epidemiological characteristics of respiratory tract virus infection before and after the prevalence of novel coronavirus. A retrospective analysis was conducted on oral and pharyngeal swabs from 302,680 children with acute respiratory infections. Colloidal gold-based assays were used to detect viral antigens, including adenovirus (ADV), influenza A (FluA), influenza B (FluB), and respiratory syncytial virus (RSV).

Toxic effects of combined exposure to carbamazepine and triclosan on adult zebrafish (Danio rerio): Insights into acute mortality, neurotransmitters, biochemical response, and histopathology.

As two representative pharmaceuticals and personal care products (PCPPs), carbamazepine (CBZ) and triclosan (TCS) are frequently detected in aquatic ecosystems worldwide, but their toxicological interactions remain unclear. This work evaluated the combined toxicity of CBZ and TCS to zebrafish (Danio rerio) in terms of acute mortality, biochemical response, and histopathology. The results showed that the 96-h acute toxicity interaction of CBZ and TCS fitted well to the concentration addition (CA) model, suggesting an additive effect.

Wogonoside ameliorates oxidative damage in tubular epithelial cells of diabetic nephropathy by modulating the HNF4A-NRF2 axis.

Diabetic nephropathy (DN), a leading cause of end-stage renal disease, presents significant challenges due to its complex pathophysiology and limited effective treatment options. Increasing evidence suggests that tubular injury is an early event preceding glomerular damage in DN. Wogonoside, a natural flavonoid derived from Scutellaria baicalensis, has not been previously reported for DN treatment.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

Ultralow Power Optoelectronic Memtransistors Based on Vertical WS/InSe van der Waals Heterostructures.

Memtransistors composed of 2D van der Waals (vdW) heterostructures are crucial for constructing artificial synaptic devices and realizing neuromorphic computing. The functional integration containing ultralow power, nonvolatile memory, and biomimetic synaptic behavior endows such devices with broad prospects. Here, we develop an optoelectronic memtransistor based on the WS/InSe vdW heterostructure and realize significant optical and electrical synaptic properties, which can simulate both short-range plasticity (STP) and long-range plasticity (LTP) of biological synapses.

Comparative analysis of perioperative renal function in patients undergoing heart transplantation and left ventricular assist device implantation: a multicenter retrospective study.

Background: Renal function is a crucial factor affecting the prognosis of patients with end-stage heart failure (HF). The differential impacts of heart transplantation and left ventricular assist device (LVAD) implantation on renal function are unclear. Therefore, we compared the perioperative renal function changes in patients who underwent heart transplantation with that of patients who underwent LVAD implantation.

A B7H3-targeting antibody-drug conjugate in advanced solid tumors: a phase 1/1b trial.

Antibody-drug conjugates (ADCs) have emerged as a transformative modality in the treatment of solid tumors. YL201, a novel B7H3-targeting ADC, leverages a tumor microenvironment activable linker-payload platform, coupled with a novel topoisomerase 1 inhibitor via a protease-cleavable linker. Here we report the findings from a large-scale, global, multicenter, phase 1 trial evaluating the safety, pharmacokinetics and preliminary efficacy of YL201 in patients with advanced solid tumors refractory to standard therapies.

Status of Cardiac Magnetic Resonance in Clinical Application and Scientific Research: A National Survey in China.

Background: Cardiovascular magnetic resonance (CMR) is rapidly expanding in China, yet comprehensive national data on its clinical application and research status are limited. This study aims to evaluate the current landscape of CMR across the country.

Methods: An electronic survey was conducted targeting two groups: physicians trained at the Fuwai Fellowship Program and members of the Chinese Society of Radiology.

The interaction between starch and gluten and related wheat-based noodles quality, a review.

Starch and gluten, the primary components of wheat, play critical roles in determining noodle quality through their synergistic interactions. To unveil the influence of starch-gluten protein interactions on the quality of noodles, further comprehensive exploration in this domain remains imperative. The current understanding of the interactions between gluten and starch in noodles processing was reviewed, with emphasis on water competition, space competition, and covalent and non-covalent interactions.

Metabolic profiling of 5- Methoxy-N,N-diallyltryptamine in human liver microsomes and zebrafish using LC-Orbitrap MS.

The metabolic profiles of tryptamine-derived new psychoactive substance 5-Methoxy-N, N-diallyltryptamine (5-MeO-DALT) were investigated using both zebrafish and human liver microsome models. The ultra-high performance liquid chromatography Q Exactive Quadrupole-Orbitrap high resolution mass spectrometer (UPLC-Q-Orbitrap-HRMS) was employed to analyze the intoxicated zebrafish samples, as well as human liver microsomes samples. The mass spectrometric data were analyzed by a software of Compound Discoverer with a database of potential metabolites.

Multienergy Codriven Electron Transfer Across the Nano-Bio Interface for Efficient Photobiocatalysis.

Integrating biocatalysis with nanophotocatalysis provides a promising pathway to address the knotty environmental and energy problems. However, energy loss during the transfer of extracellular electrons across the nano-bio interface seriously limits the efficiency of whole-cell-based photobiocatalytic systems. Herein, we demonstrate an integrated multienergy codriven reaction platform containing BaTiO nanoparticles (BTO) for harvesting mechanical energy from flowing water to elevate the interfacial electric field, BiVO quantum dots (BQD) for harvesting light energy to generate photocarriers, and () for accepting photoelectrons to accomplish the biocatalytic reactions.

Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Infections.

The ubiquitous opportunistic pathogen () causes biofilm-associated drug-resistant infections that often lead to treatment failure. Targeting the bacterium's quorum sensing (QS) and iron homeostasis presents a promising strategy to combat biofilm formation. This study synthesized benzothiazole-conjugated hydroxamic acid derivatives as dual-acting biofilm inhibitors, and compound was identified as the hit compound with potent submicromolar biofilm inhibitory activity (IC = 0.

Electron Itinerancy Mediated by Oxygen Vacancies Breaks the Inert Electron Chain to Boosts Lithium-Oxygen Batteries Electrocatalysis.

The complex interaction between dopants and oxygen vacancies (Vo) in metal oxides is crucial for enhancing the adsorption and electron transfer processes of Li-O2 batteries. However, the synergetic mechanism among Vo, dopants, and the host matrix remains unclear. Herein, Ru single-atom-modified TiO2 nanorod (Ru1-TiO2-x) with abundant Vo were fabricated, serving as an efficient catalyst for Li-O2 batteries.

Efficient Extraction, Chemical Characterization, and Bioactivity of Essential Oil From Pine Needles.

Introduction: Pine needles are a rich source of bioactive compounds, and there are few reports on the extraction and identification of active substances in various types of pine needles.

Objectives: The objective of this study is to enhance the efficiency and yield of pine needle essential oil extraction by employing an innovative ultrasonic-assisted salt-out hydrodistillation technology. It also aims to establish a correlation between gas chromatography-mass spectrometry (GC-MS) and electronic nose (E-nose) to distinguish essential oils from Cedrus deodara, Pinus thunbergii, Pinus massoniana, and Pinus koraiensis.

δN and δC cycles in narwhal () embedded teeth reveal seasonal variation in ecology and/or physiology.

Monitoring Arctic marine mammals in response to rapid climate change requires reliable longitudinal data. To obtain such data is challenging, but sequential measurements of stable isotopes (SI) from metabolically inert tissues like dentine allow for chronological reconstruction of SI data that can provide insights into whale life history, behaviour and physiology. This study examined dentine samples from narwhal embedded canines to reconstruct individual SI profiles and assess intra-annual variation in δN and δC.

Developing an advanced course of vaccinology in middle-income countries: The case of China.

•We provide the Chinese Vaccinology Course was the only national advanced vaccinology training course in China, in response to the global call to improve vaccine capacity and meet local needs.•To address the challenges for both the development of the country as well as world sustainability and to address the major needs of the country and for the lives and health of the people.•Science and technology has provided strong support in controlling infection, developing vaccines and promoting drug research and development (R& D), CNVAC provide model problems and solutions for the research community.

Applying virtual reality to sail education: an innovative strategy to enhance knowledge learning for student novices.

Background: Sailing has been proved beneficial for physical and mental health promotion, which has made it a prevalent sport among children and adolescents. Nevertheless, the existing pedagogical strategies cannot satisfy students' demands for learning. To bridge this gap, virtual reality (VR) is considered an innovative approach to addressing the challenges in sailing education.

Asymmetric Synthesis of S(IV)-Stereogenic Sulfinimidate Esters by Sulfinamide Activation.

Catalyst-controlled approaches for the synthesis of S-stereogenic compounds have propelled significant advancements in asymmetric synthetic chemistry. In contrast, control over S-heteroatom (e.g.

Synergistic Effects of Ultrasound and pH-Shifting on the Solubility and Emulsification Properties of Peanut Protein.

Peanut protein is a byproduct of peanut oil extraction with limited applications within the food sector due to its low solubility and emulsifying properties. This study investigated the influences and mechanisms of high-intensity ultrasound (HIU, 200~600 W) and pH-shifting (pH 12), either individually or jointly, on the structure, solubility, and emulsifying properties of PP. Results indicated that the solubility of PP significantly increased after the combined treatment, particularly when the HIU power was 300 W ( < 0.

Construction of an Efficient Engineered Strain for Chaetoglobosin A Bioresource Production from Potato Starch Industrial Waste.

Chaetoglobosin A (CheA), a typical structure of the cytochalasin family, exhibits outstanding efficacy against a variety of tumor cells and plant pathogens. However, its low yield and high production cost are major obstacles limiting its wide application. In order to increase CheA yield, an engineered strain was established by overexpressing , the gene encoding the MFS family's efflux pump, on chassis cells lacking , which have been shown to act as a negative regulator of CheA biosynthesis.

Effects of Yeast Culture on Lamb Growth Performance, Rumen Microbiota, and Metabolites.

The effects of incorporating yeast culture (YC) into pelleted feeds on sheep production and the potential impact on rumen microbial populations, microbial metabolism, and fermentation have not been extensively studied. This study aimed to evaluate the effect of YC on growth performance, rumen tissue development, rumen fermentation, and rumen microflora in sheep and to explore the potential microbial mechanisms involved. Fifty healthy 3-month-old male lambs of small-tailed Han sheep, with an average weight of 28.

ECM Stiffness-Induced Redox Signaling Enhances Stearoyl Gemcitabine Efficacy in Pancreatic Cancer.

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, largely due to its dense fibrotic stroma that promotes drug resistance and tumor progression. While patient-derived organoids (PDOs) have emerged as promising tools for modeling PDAC and evaluating therapeutic responses, the current PDO models grown in soft matrices fail to replicate the tumor's stiff extracellular matrix (ECM), limiting their predictive value for advanced disease.

Methods: We developed a biomimetic model using gelatin-based matrices of varying stiffness, achieved through modulated transglutaminase crosslinking rates, to better simulate the desmoplastic PDAC microenvironment.