A nomogram for predicting overall survival in patients with gastric cancer based on tumor suppressor RCAN1.4 expression and clinical risk factors.

Gastric cancer (GC) is one of the most prevalent malignant tumors in the world and has an extremely poor prognosis. Regulator of calcineurin 1 (RCAN1), a known tumor suppressor in various cancers, has an undefined role in the proliferation and metastasis of GC. Primary tumor and paired normal gastric tissues were collected from 77 patients with GC for evaluating the mRNA levels of 3 RCAN1 transcripts.

Highly Thermal-Conductive Cubic Boron Arsenide: Single-Crystal Growth, Properties, and Future Thin-Film Epitaxy.

Heat dissipation has become a critical challenge in modern electronics, driving the need for a revolution in thermal management strategies beyond traditional packaging materials, thermal interface materials, and heat sinks. Cubic boron arsenide (c-BAs) offers a promising solution, thanks to its combination of high thermal conductivity and high ambipolar mobility, making it highly suitable for applications in both electronic devices and thermal management. However, challenges remain, particularly in the large-scale synthesis of a high-quality material and the tuning of its physical properties.

Hot Nanogap Networks-In-Triangular Nanoframes: A Strategy for Positioning Adsorbates Near Hot Spots.

This study reports the synthesis of plasmonic hot nanogap networks-in-triangular nanoframes (NITNFs), featuring narrow intraparticle nanogap networks embedded within triangular nanoframes. Starting from Au nanotriangles, Pt NITNFs are synthesized through a cascade reaction involving simultaneous Pt deposition and Au etching in a one-pot process. The Pt NITNFs are then transformed into plasmonically active Au NITNFs via Au coating.

Detection and recognition of foreign objects in Pu-erh Sun-dried green tea using an improved YOLOv8 based on deep learning.

The quality and safety of tea food production is of paramount importance. In traditional processing techniques, there is a risk of small foreign objects being mixed into Pu-erh sun-dried green tea, which directly affects the quality and safety of the food. To rapidly detect and accurately identify these small foreign objects in Pu-erh sun-dried green tea, this study proposes an improved YOLOv8 network model for foreign object detection.

Pan-Cancer Analysis Reveals the Potential of PLOD1 as a Prognostic and Immune Biomarker for Human Cancer.

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1) is known as an enhancer of collagen fiber deposition and cross-linking stability. However, there is limited information on its function in tumors. In this study, we aimed to elucidate the function and potential mechanism of action of PLOD1 across cancers.

Global, regional, and national prevalence and trends of infertility among individuals of reproductive age (15-49 years) from 1990 to 2021, with projections to 2040.

Study Question: What is the prevalence and trend of infertility among individuals of childbearing age at global, regional, and national levels by sex and socio-demographic index (SDI) across 21 regions and 204 countries and territories?

Summary Answer: Our findings reveal a growing prevalence of infertility among individuals aged 15-49 years worldwide from 1990 to 2021, with an expected continued increase through 2040.

What Is Known Already: Infertility is a persistent global reproductive health issue, leading to significant societal and health consequences. No study has specifically described the current prevalence of infertility, its secular trend, or the variations between regions or countries with different SDI levels.

WTAP/IGF2BP3 Mediated m6A Modification of SOD2 mRNA Aggravates the Tumourigenesis of Colorectal Cancer.

Wilms tumor 1-associated protein (WTAP) has been validated to be a crucial regulator in the tumorigenesis and advancement of diverse malignancies. This study intended to probe the impacts of WTAP on colorectal cancer (CRC) progression from the perspective of N6-methyladenosine (m6A) modification. The differential expression patterns of WTAP in clinical CRC samples and cultured cell lines were validated via qRT-PCR and western blot.

Gut-liver translocation of pathogen Klebsiella pneumoniae promotes hepatocellular carcinoma in mice.

Hepatocellular carcinoma (HCC) is accompanied by an altered gut microbiota but whether the latter contributes to carcinogenesis is unclear. Here we show that faecal microbiota transplantation (FMT) using stool samples from patients with HCC spontaneously initiate liver inflammation, fibrosis and dysplasia in wild-type mice, and accelerate disease progression in a mouse model of HCC. We find that HCC-FMT results in gut barrier injury and translocation of live bacteria to the liver.

Raddeanin A (RA) Inhibited EMT and Stemness in Glioblastoma via downregulating Skp2.

Glioblastoma (GBM), notorious for its poor prognosis, stands as a formidable challenge within the central nervous system tumor category, primarily due to its intricate pathology that encompasses stemness and the epithelial-mesenchymal transition (EMT). The ubiquity of S phase kinase-associated protein 2 (Skp2) overexpression in GBM, a protein implicated in both EMT and stemness traits, correlates with increased drug resistance, elevated tumor grades, and adverse outcomes. This investigation delves into the impact of Raddeanin A (RA), a triterpenoid compound extracted from Anemone raddeana Regel, on GBM, with a special focus on its influence over Skp2 expression levels.

HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.

Advanced atherosclerosis is the pathological basis for acute cardiovascular events, with significant residual risk of recurrent clinical events despite contemporary treatment. The death of foamy macrophages is a main contributor to plaque progression, but the underlying mechanisms remain unclear. Bulk and single-cell RNA sequencing demonstrated that massive iron accumulation in advanced atherosclerosis promoted foamy macrophage ferroptosis, particularly in low expression of triggering receptor expressed on myeloid cells 2 (TREM2) foamy macrophages.

Preoperative inflammatory burden index for prognostication in esophageal squamous cell carcinoma undergoing radical resection.

Background: The Inflammatory burden Index (IBI) is an effective predictor for a range of malignancies. However, the significance of IBI in esophageal squamous cell carcinoma (ESCC) needs to be further verified. The aim of this study was to verify the predictive power of IBI in ESCC undergoing radical resection.

Enriched Electrophilic Oxygen Species on Ru Optimize Acidic Water Oxidation.

Ruthenium oxide (RuO) is considered one of the most promising catalysts for replacing iridium oxide (IrO) in the acidic oxygen evolution reaction (OER). Nevertheless, the performance of RuO remains unacceptable due to the dissolution of Ru and the lack of *OH in acidic environments. This paper reports a grain boundary (GB)-rich porous RuO electrocatalyst for the efficient and stable acidic OER.

Gold Tetrahedral Nanoframes with Mono-Rim or Dual-Rim Morphologies for Enhanced Near-Field Focusing in SERS.

This study presents a synthesis method for Au tetrahedral nanoframes (Td NFs) through a rationally designed multiple-step process, followed by an investigation of their distinctively ordered self-assembly for enhanced performance in surface-enhanced Raman spectroscopy (SERS). Two distinct Au Td NF building blocks are synthesized, exhibiting mono-rim or dual-rim morphologies. The mono-rim structure lacks intra-nanogaps, whereas the dual-rim configuration features well-defined intra-nanogaps.

Localized COUP-TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts.

Decellularized allografts have emerged as promising candidates for vascular bypass grafting, owing to their inherent bioactivity and minimal immunogenicity. However, graft failure that results from suboptimal regeneration and pathological remodeling has hindered their clinical adoption. Recent advances in vascular biology highlight the pivotal role of COUP-TFII in orchestrating endothelial identity, angiogenesis, safeguarding against atherosclerosis, and mitigating vascular calcification.

High-Precision Printing Sandwich Flexible Transparent Silver Mesh for Tunable Electromagnetic Interference Shielding Visualization Windows.

Flexible transparent conductive films (FTCFs) with electromagnetic interference (EMI) shielding performance are increasingly crucial as visualization windows in optoelectronic devices due to their capabilities to block electromagnetic radiation (EMR) generated during operation. Metal mesh-based FTCFs have emerged as a promising representative in which EMI shielding effectiveness (SE) can be enhanced by increasing the line width, reducing the line spacing, or increasing mesh thickness. However, these conventional approaches decrease optical transmittance or increase material consumption, thus compromising the optical performance and economic viability.

Identification of Cuproptosis-Related Patterns Predict Prognosis and Immunotherapy Response in Hepatocellular Carcinoma.

A novel copper-dependent mode of death, cuproptosis, has been newly identified. This study developed a cuproptosis score (CS) based on the cuproptosis model to analyse the association of CS with prognosis, immune cell infiltration, drug sensitivity and immunotherapy response in hepatocellular carcinoma (HCC) patients. A typing model of cuproptosis was constructed based on the expression of 19 cuproptosis-related genes (CRGs).

Simplified ischemia-free liver transplantation by providing alternating flow of the portal vein and hepatic artery: Applicability, efficiency, and safety.

Conventional ischemia-free liver transplantation (CIFLT) represents a pioneering procedure that circumvents ischemia-reperfusion injury to livers throughout the transplant procedure. However, its complexity has limited its widespread adoption. This study introduced a simplified ischemia-free liver transplantation (SIFLT) technique by providing an alternating flow of the portal vein and hepatic artery, demonstrating its efficacy and safety.

Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2.

Free fatty acid receptors (FFARs) play critical roles in metabolic regulation and are potential therapeutic targets for metabolic and inflammatory diseases. A comprehensive understanding of the activation mechanisms and endogenous ligand selectivity of FFARs is essential for drug discovery. Here, we report two cryoelectron microscopy structures of the human FFAR1 bound to the endogenous ligand docosahexaenoic acid (DHA) and G protein as well as FFAR2 in complex with butyrate and G at 3.

Expression and clinical significance of IL-8 and Wnt2 in Helicobacter pylori-infected gastric cancer patients.

Introduction: We assessed the expression levels of interleukin-8 (IL-8) and Wnt2 in Helicobacter pylori-infected gastric cancer (GC) patients, and investigated the association of these proteins with prognosis.

Methodology: Seventy-two GC patients, including 40 cases with H. pylori infection and 32 cases without H.

Resveratrol enhances the tolerance of to potassium deficiency stress.

Potassium (K) deficiency in plants can lead to metabolic disorders and growth retardation. Currently, nearly 50% of the arable land in China is experiencing a K resource deficit, significantly hindering the development of the apple industry. Resveratrol (Res), a phytoalexin, has been extensively reported to enhance plant resistance against various abiotic stresses.

Synthesis of a highly stable Mo-Fe bimetallic metal-organic framework and its catalytic activity for the selective oxidation of sulfides under mild conditions.

A novel Mo-Fe bimetallic metal-organic framework [Fe(4,4'-bipy)MoO]·2HO (1) was synthesized and characterized by X-ray single crystal diffraction, infrared spectroscopy (IR), thermogravimetric analysis (TGA), ultraviolet-visible spectroscopy (UV-vis), and its magnetic properties were studied. The compound demonstrates insolubility in most solvents and exhibits significant chemical stability across a wide pH range. Typically, exceptional selectivity and efficient conversion of sulfides to sulfoxides using 1 with HO have been verified under ambient conditions.

High performance, pH-resistant membranes for efficient lithium recovery from spent batteries.

Cation separation under extreme pH is crucial for lithium recovery from spent batteries, but conventional polyamide membranes suffer from pH-induced hydrolysis. Preparation of high performance nanofiltration membranes with excellent pH-resistance remains a challenge. Here we synthesize a high performance nanofiltration membrane (1,4,7,10-Tetraazacyclododecane (TAD)-1,3,5-Tris(bromomethyl)benzene (TBMB) thin film composite membranes (TFCMs)) with excellent pH-stability through interfacial quaternization reaction between TAD and TBMB.

Serum Homocysteine and Atrial Fibrillation Recurrence after Catheter Ablation: A Meta-Analysis of 11 Cohort Studies Involving 2147 Patients.

The relationship between serum homocysteine (Hcy) levels and atrial fibrillation (AF) recurrence following catheter ablation remains unclear. This meta-analysis aims to investigate this association. Comprehensive searches in PubMed, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases identified relevant studies published up to May 25, 2024.

Suppression of Hepatocyte Ferroptosis via USP19-Mediated Deubiquitination of SLC7A11 in Ischemia-Free Liver Transplantation.

Ischemia-free liver transplantation (IFLT) is developed as a novel clinical approach to avoid ischemia-reperfusion injury (IRI). This study aims to identify the most distinguished programmed cell death pathway in grafts undergoing IFLT versus conventional liver transplantation (CLT) and to explore the underlying mechanism. Ferroptosis is the most distinct programmed cell death form between IFLT and CLT grafts.