USP31 Activates the Wnt/β-catenin Signaling Pathway and Promotes Gastric Cancer Cell Proliferation, Invasion and Migration.

Background: Gastric cancer (GC) has a poor prognosis because it is highly aggressive, yet there are currently few effective therapies available. Although protein ubiquitination has been shown to play a complex role in the development of gastric cancer, to date, no efficient ubiquitinating enzymes have been identified as treatment targets for GC.

Methods: The TCGA database was used for bioinformatic investigation of ubiquitin-specific protease 31 (USP31) expression in GC, and experimental techniques, including Western blotting, qRT-PCR, and immunohistochemistry, were used to confirm the findings.

Microstructure and Mechanical Properties of As-Aged Mg-Zn-Sn-Mn-Al Alloys.

The microstructure and mechanical properties of as-aged Mg-6Zn-4Sn-1Mn-xAl (ZTM641-xAl, x = 0, 0.2, 0.5, 1, 2, 3 and 4 wt.

A Micro-Nano Structure Formed by SiC/Graphene Oxide Self-Assembly Improves the Wear Resistance and Corrosion Resistance of an Epoxy-Based Composite Coating.

In air and railway transportation, corrosion and wear lead to the rapid failure of equipment. Epoxy (EP)-based coatings are widely used in research on the anti-corrosion of organic coatings, but their application as materials for wear resistance is limited due to their non-abrasive properties. In this study, a novel high-performance epoxy-based composite coating was developed through the self-assembly of silicon carbide (SiC) and graphene oxide (GO) and the tuning of the interfacial structure with epoxy resin.

Study on Bone-like Microstructure Design of Carbon Nanofibers/Polyurethane Composites with Excellent Impact Resistance.

It is a challenge to develop cost-effective strategy and design specific microstructures for fabricating polymer-based impact-resistance materials. Human shin bones require impact resistance and energy absorption mechanisms in the case of rapid movement. The shin bones are exciting biological materials that contain concentric circle structures called Haversian structures, which are made up of nanofibrils and collagen.

Study on Mechanical Properties and High-Speed Impact Resistance of Carbon Nanofibers/Polyurethane Composites Modified by Polydopamine.

Polyurethane elastomers (PUE), with superior mechanical properties and excellent corrosion resistance, are applied widely to the protective capability of structures under low-speed impact. However, they are prone to instantaneous phase transition, irreversible deformation and rupture even arising from holes under high-speed impact. In this paper, mussel adhesion proteins were applied to modify carbon nanofibers (CNFs) in a non-covalent way, and creatively mixed with PUE.

Preparation of poly(ionic liquid)/multi-walled carbon nanotube fillers using divinylbenzene as a linker to enhance the impact resistance of polyurethane elastomers.

The brittle fracture of polyurethane elastomer (PUE) under high-speed impact limits its application in high-speed impact protection. Here, based on the principle of free radical polymerization and π-π conjugation, composite nanoparticles (C-MWCNTs) are prepared by copolymerization of epoxy group ionic liquid (GVIMBr) and divinylbenzene (DVB) on MWCNTs using DVB as a linker. C-MWCNTs participate in the curing process of PUE through epoxy groups to form crosslinked C-MWCNTs/PUE, which improves the energy absorption and high-speed impact properties of PUE.

In Situ Grazing-Incidence SAXS Investigation of Thermal-Induced Self-Assembly Process of PS--PMMA Films Deposited on Surface-Modified Substrate.

Directed self-assembly of block copolymers (BCPs) is widely investigated for its potential application in surface patterning. The self-assembly kinetics of BCP based on modified layers is the key to realizing structural control for obtaining highly ordered lamellar grains. In this study, morphological evolution of PS--PMMA films during the thermal-induced self-assembly process was investigated via the in situ grazing-incidence small-angle X-ray scattering (GISAXS) technique.

In Situ Grafted Composite Nanoparticles-Reinforced Polyurethane Elastomer Composites with Excellent Continuous Anti-Impact Performance.

Polyurethane elastomer (PUE) has attracted much attention in impact energy absorption due to its impressive toughness and easy processability. However, the lack of continuous impact resistance limits its wider application. Here, an amino-siloxane (APTES) grafted WS-coated MWCNTs (A-WS@MWCNTs) filler was synthesized, and A-WS@MWCNTs/PUE was prepared by using the filler.

Effects of Modified AlO-Decorated Ionic Liquid on the Mechanical Properties and Impact Resistance of a Polyurethane Elastomer.

In this work, a new composite material with excellent dynamic impact resistance and outstanding quasi-static mechanical properties was synthesized. The composite material is composed of a polyurethane elastomer and a novel nano-polymer. The nano-polymer was composed of silane coupling agent-modified alumina microspheres and functionalized ionic liquids by double bond polymerization.

Effect of Y Addition on the Microstructure and Mechanical Properties of ZM31 Alloy.

Effects of different Y contents (0, 0.3, 0.7, 1.

β-GaO nanorod arrays with high light-to-electron conversion for solar-blind deep ultraviolet photodetection.

Vertically aligned nanorod arrays (NRAs), with effective optical coupling with the incident light and rapid electron transport for photogenerated carriers, have attracted much interest for photoelectric devices. Herein, the monoclinic β-GaO NRAs with an average diameter/length of 500 nm/1.287 μm were prepared by the hydrothermal and post-annealing method.

Self-Powered Ultraviolet Photodetector with Superhigh Photoresponsivity (3.05 A/W) Based on the GaN/Sn:GaO pn Junction.

Ultraviolet (UV) radiation has a variety of impacts including the health of humans, the production of crops, and the lifetime of buildings. Based on the photovoltaic effect, self-powered UV photodetectors can measure and monitor UV radiation without any power consumption. However, the current low photoelectric performance of these detectors has hindered their practical use.

Knockdown of CCNO decreases the tumorigenicity of gastric cancer by inducing apoptosis.

Purpose: Recently, Cyclin O (CCNO) has been reported to be a novel protein of the cyclin family. However, the clinical significance and functional roles of CCNO in human cancer, including gastric cancer (GC), remain largely unexplored. In this study, we investigated the clinical and functional roles of CCNO in GC.

Effect of Ti Transition Layer Thickness on the Structure, Mechanical and Adhesion Properties of Ti-DLC Coatings on Aluminum Alloys.

Multilayers of Ti doped diamond-like carbon (Ti-DLC) coatings were deposited on aluminum alloys by filtered cathodic vacuum arc (FCVA) technology using C₂H₂ as a reactive gas. The effect of different Ti transition layer thicknesses on the structure, mechanical and adhesion properties of the coatings, was investigated by scanning electron microscopy (SEM), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), nanoindentation and a scratch tester. The results showed that the Ti transition layer could improve interfacial transition between the coating and the substrate, which was beneficial in obtaining excellent adhesion of the coatings.

Alignment Control of Nematic Liquid Crystal using Gold Nanoparticles Grafted by the Liquid Crystalline Polymer with Azobenzene Mesogens as the Side Chains.

The gold nanoparticles highly grafted by a liquid crystalline polymer (LCP) with azobenzene mesogens as the side chain (denoted as Au@TE-PAzo NPs) are successfully designed and synthesized by the two-phase Brust-Schiffrin method. The chemical structures of the monomer and polymer ligands have been confirmed by nuclear magnetic resonance, and the molecular weight of the polymer is determined by gel permeation chromatography. The combined analysis of transmission electron microscopy and thermogravimetric analysis shows that the size of the nanoparticles is 2.

Quantitative proteomics analysis of the role of tetraspanin-8 in the drug resistance of gastric cancer.

Gastric cancer, due to its high incidence rate, is the second leading cause of cancer-related mortality worldwide. Chemotherapy is an important component of the multimodal treatment for gastric cancer; however, a significant impediment to successful treatment is multidrug resistance (MDR) in patients with gastric cancer. In the present study, the protein profiles of the MDR cell line, SGC7901/DDP, and its parental cell line, SGC7901, were comparatively analyzed through an iTRAQ-based quantitative proteomics technique.

Codelivery of salinomycin and docetaxel using poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles to target both gastric cancer cells and cancer stem cells.

Cancer stem cells (CSCs) in gastric cancer (GC) have been established recently as key therapeutic targets for the successful treatment of GC. Emerging evidence suggests that both CSCs and cancer cells should be eradicated to achieve optimal therapeutic efficacy. In the present study, salinomycin, which has been reported to kill CSCs, was used in combination with docetaxel, a chemotherapeutic drug that is used as first-line therapy in GC, to eradicate both GC stem cells (SCs) and cancer cells.

Probing the surface microstructure of layer-by-layer self-assembly chitosan/poly(l-glutamic acid) multilayers: A grazing-incidence small-angle X-ray scattering study.

This study characterized the surface structure of layer-by-layer self-assembly chitosan/poly(L-glutamic acid) multilayers through grazing-incidence small-angle X-ray scattering (GISAXS), X-ray reflectivity (XRR), and atomic force microscopy (AFM). A weakly long-period ordered structure along the in-plane direction was firstly observed in the polyelectrolyte multilayer by the GISAXS technique. This structure can be attributed to the specific domains on the film surface.

Cellulose nanofibrils aerogels generated from jute fibers.

In this work, we report the cellulose nanofibrils extracted from the pristine jute fibers via the pretreatments followed by the TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl radical)-mediated oxidation and mechanical disintegration. The effects of pretreatments by using the NaOH solution and dimethyl sulfoxide solvent on the fiber morphology and macro/micro-structures were investigated by polarizing microscope and synchrotron radiation wide/small-angle X-ray scattering (WAXS/SAXS). The cellulose nanofibrils exhibit a diameter ranging from 5 nm to 20 nm and a length of several micrometers, which have been assembled into cellulose aerogels by the lyophilization of as-prepared nanofibrils dispersions with various concentrations.