Sex-specific effects of dietary salt intake on circulating Alzheimer's disease-related biomarkers in aged rats.

This study collected plasma samples from aged male and female Sprague Dawley rats (22-24 months old) with varying long-term dietary salt intake (low, 0.1% NaCl; normal, 0.4% NaCl; or clinically relevant high salt, 1% NaCl; for twelve weeks).

Severe cutaneous drug toxicity following disitamab vedotin treatment for metastatic gastric cancer: a case report.

Background: This study reports a case of severe cutaneous toxicity in a patient with metastatic gastric cancer induced by disitamab vedotin, emphasizing the need for careful monitoring and management in such treatments.

Case Presentation: A 71-year-old female was admitted to hospital complaining of serious rashes following the first cycle of disitamab vedotin regimen for metastatic gastric cancer. The doctor diagnosedtoxic epidermal necrolysis (TEN) induced by the drug.

Exploring a novel outcome measure of symptom progression in knee osteoarthritis utilizing a large randomized trial.

Objectives: Explore a newly defined composite measure of symptom progression for knee osteoarthritis (KOA) in a large, randomized study of a potential disease-modifying osteoarthritis drug (DMOAD).

Design: Using longitudinal KOA studies, a potential composite endpoint of time to symptom progression was defined as the first occurrence of worsening of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain of ≥10 points with no improvement (≤9 point decrease) in WOMAC Function (0-100 scale). A post hoc analysis explored discrimination and association with structural outcomes in the sprifermin FORWARD trial through Years 3 and 5.

The impact of salt consumption on cardiometabolic and cognitive health in aged female rats.

Health concerns about excess dietary salt have traditionally focused on its relationship with hypertension and the increased risk of cognitive impairment. However, research has often overlooked the unique health concerns and physiological differences between men and women, leading to gaps in knowledge, particularly regarding disease prevention and treatment strategies for women. The present study examined aged female rats over 12 weeks, using control, low, and high salt diets to mimic the post-menopausal phase in human females when cardiovascular risks typically increase.

Unbiased analysis of knee cartilage thickness change over three years after sprifermin vs. placebo treatment - A post-hoc analysis from the phase 2B FORWARD study.

Objective: Post-treatment cartilage morphometry in the FORWARD study was performed without blinding to MRI acquisition order, involving potential reader bias. Here we obtained unbiased estimates of cartilage change post-treatment, reading year (Y)2 and Y5 MRIs with blinding to time point. We studied whether post-treatment cartilage thickness change differed between sprifermin- and placebo-treated knees.

Is detection of disease-modifying osteoarthritis drug treatment more effective when performing cartilage morphometry without blinding to MR image acquisition order?

Objective: We here explore whether observed treatment effects of a putative disease-modifying osteoarthritis drug (DMOAD) are greater when cartilage morphometry is performed with rather than without knowledge of magnetic resonance imaging (MRI) acquisition order (unblinded/blinded to time point).

Methods: In the FORWARD (FGF-18 Osteoarthritis Randomized Controlled Trial with Administration of Repeated Doses) randomized controlled trial, 549 knee osteoarthritis patients were randomized 1:1:1:1:1 to three once-weekly intra-articular injections of placebo, 30 µg sprifermin every 6 or 12 months (M), or 100 µg every 6/12 M. After year 2, cartilage segmentation of BL through 24 M MRIs was performed, with blinding to acquisition order.

Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation.

Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for the proper development and function of meningeal lymphatic vessels and that activating Piezo1 through transgenic overexpression or treatment with the chemical agonist Yoda1 is sufficient to increase cerebrospinal fluid (CSF) outflow by improving lymphatic absorption and transport. The abnormal accumulation of CSF, which often leads to hydrocephalus and ventriculomegaly, currently lacks effective treatments.

Preoperative differentiation of gastric schwannomas and gastrointestinal stromal tumors based on computed tomography: a retrospective multicenter observational study.

Introduction: Gastric schwannoma is a rare benign tumor accounting for only 1-2% of alimentary tract mesenchymal tumors. Owing to their low incidence rate, most cases are misdiagnosed as gastrointestinal stromal tumors (GISTs), especially tumors with a diameter of less than 5 cm. Therefore, this study aimed to develop and validate a diagnostic nomogram based on computed tomography (CT) imaging features for the preoperative prediction of gastric schwannomas and GISTs (diameters = 2-5 cm).

Age differences in the impact of dietary salt on metabolism, blood pressure and cognitive function in male rats.

The influence of salt consumption on physiological processes, especially blood pressure (BP), metabolism, and cognition, remains a topical concern. While guidelines endorse reduced salt diets, there are gaps in understanding the age-specific implications and challenges in adherence. The present study delved into the differential effects of salt intake on young adult and aged male rats over a 12-week period, using control, low-, and high-salt diets.

Phosphorus Addition Reduces Seedling Growth and Survival for the Arbuscular Mycorrhizal Tree (Lauraceae) and Ectomycorrhizal Tree (Fagaceae) in Fragmented Forests in Eastern China.

Global changes in nutrient deposition rates and habitat fragmentation are likely to have profound effects on plant communities, particularly in the nutrient-limited systems of the tropics and subtropics. However, it remains unclear how increased phosphorus (P) supply affects seedling growth in P-deficient subtropical fragmented forests. To explore this, we applied P to 11 islands in a subtropical Chinese archipelago and examined the results in combination with a contemporary greenhouse experiment to test the influence of P addition on seedling growth and survival.

Effect of Heat Treatment on the Digestive Characteristics of Different Soybean Oil Body Emulsions.

Soybean oil body (SOB) emulsions were prepared using OBs extracted at pH 11.0 and pH 7.0.

Relationship between multi-slice computed tomography features and pathological risk stratification assessment in gastric gastrointestinal stromal tumors.

Background: Computed tomography (CT) imaging features are associated with risk stratification of gastric gastrointestinal stromal tumors (GISTs).

Aim: To determine the multi-slice CT imaging features for predicting risk stratification in patients with primary gastric GISTs.

Methods: The clinicopathological and CT imaging data for 147 patients with histologically confirmed primary gastric GISTs were retrospectively analyzed.

Clinical and CT Imaging Differences Between Gastric Schwannoma and Gastric Leiomyoma.

Objective: To determine whether computed tomography (CT) imaging features can be used to differentiate gastric schwannoma (GS) from gastric leiomyoma (GL) and to develop a nomogram as a predictive model.

Study Design: Retrospective study. Place and Duration of the Study: Department of Medical Imaging, Affiliated Hospital of Jining Medical University, Jining, Shandong, China, from July 2009 to June 2022.

Soybean balanced the growth and defense in response to SMV infection under different light intensities.

Light is essential for the growth and defense of soybean. It is not clear how soybeans adjust their defenses to different light environments with different cropping patterns. The mechanism of soybean response to (SMV) infection under different light intensities was analyzed by RNA-seq sequencing method.

Identification and Molecular Binding Mechanism of Novel α-Glucosidase Inhibitory Peptides from Hot-Pressed Peanut Meal Protein Hydrolysates.

Hot-pressed peanut meal protein hydrolysates are rich in Arg residue, but there is a lack of research on their α-glucosidase inhibitory activity. In this study, different proteases were used to produce hot-pressed peanut meal protein hydrolysates (PMHs) to evaluate the α-glucosidase inhibitory activity. All PMHs showed good α-glucosidase inhibitory activity with the best inhibition effect coming from the dual enzyme system of Alcalase and Neutrase with an IC of 5.

Digestive characteristics of oil body extracted from soybean aqueous extract at different pHs.

Soybean oil bodies (SOBs), a natural source of pre-emulsified oil, have important potential applications in food industry. In this study, SOBs were extracted from raw soybean milk at pH 5.0, 7.

Effects of soybean oil on rheological characteristics of dough under high hydrostatic pressure.

In order to improve the stability of dough with soybean oil, this article explored the effect of soybean oil addition on the rheological characteristics of dough under high hydrostatic pressure. The results showed that, compared with the dough without soybean oil, the β-sheet, disulfide bonds content, and gauche-gauche-gauche in the dough increased by 4.23%, 0.

Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion.

Background: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1) cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI calcium release-activated calcium modulator 1)-mediated mechanotransduction pathway that triggers lymphatic sprouting through Notch downregulation in response to fluid flow. However, the identity of its upstream mechanosensor remains unknown.

Batch Process Monitoring Based on Quality-Related Time-Batch 2D Evolution Information.

This paper proposed a quality-related online monitoring strategy based on time and batch two-dimensional evolution information for batch processes. In the direction of time, considering the difference between each phase and the steady part and the transition part in the same phase, the change trend of the regression coefficient of the PLS model is used to divide each batch into phases, and each phase into parts. The phases, the steady parts, and the transition parts are finally distinguished and dealt with separately in the subsequent modeling process.

Slow Time-Varying Batch Process Quality Prediction Based on Batch Augmentation Analysis.

In this paper, focusing on the slow time-varying characteristics, a series of works have been conducted to implement an accurate quality prediction for batch processes. To deal with the time-varying characteristics along the batch direction, sliding windows can be constructed. Then, the start-up process is identified and the whole process is divided into two modes according to the steady-state identification.

Effect of water bath-assisted water extraction on physical and chemical properties of soybean oil body emulsion.

Soybean oil body (SOB), rich in polyunsaturated fatty acids and biologically active substances, is used as a natural emulsifier in food processing. In addition, SOB is healthier than synthetic emulsifiers. However, the physical and chemical properties of the SOB emulsion directly affect its application in food processing.