Comparison of Gensini score and SYNTAX score for predicting in-stent restenosis in patients with coronary artery disease and drug-eluting stent implantation.

The present study was aimed to investigate whether Gensini score or SYNTAX score was a valuable tool to predict in-stent restenosis (ISR) in coronary artery disease (CAD) patients with drug-eluting stents (DES) implantation. A retrospective case-control study and a validating retrospective cohort study were designed. All subjects' information was collected from the First Affiliated Hospital of Xinjiang Medical University.

A precision oncology-focused deep learning framework for personalized selection of cancer therapy.

Precision oncology matches tumors to targeted therapies based on the presence of actionable molecular alterations. However, most tumors lack actionable alterations, restricting treatment options to cytotoxic chemotherapies for which few data-driven prioritization strategies currently exist. Here, we report an integrated computational/experimental treatment selection approach applicable for both chemotherapies and targeted agents irrespective of actionable alterations.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes.

Background: Transient Receptor Potential Melastatin 4 (TRPM4), a non-selective cation channel, plays a critical role in cardiac conduction abnormalities. Brg1, an ATP-dependent chromatin remodeler, is essential for regulating gene expression in both heart development and disease. Our previous studies demonstrated Brg1 impacted on cardiac sodium/potassium channels and electrophysiological stability, its influence on TRPM4 expression and function remained unexplored.

Enhancing astaxanthin accumulation in immobilized Haematococcus pluvialis via alginate hydrogel membrane.

Immobilized cultivation is anticipated to be effective for enhancing both biomass and astaxanthin accumulation in Haematococcus pluvialis (H. pluvialis). A novel fabrication method of alginate hydrogel membrane (AHM) was introduced for immobilized cultivation of H.

Acupuncture and moxibustion as adjunctive therapy for postoperative gastrointestinal dysfunction in gastric cancer: a systematic review and network meta-analysis.

Objectives: This study aimed to evaluate and compare the efficacy and safety of different acupuncture and moxibustion techniques as adjunctive therapy in addressing Postoperative gastrointestinal dysfunction (PGD) associated with gastric cancer (GC).

Methods: Eight medical databases were comprehensively searched for relevant randomized controlled trials (RCTs) as of October 2024. A network meta-analysis (NMA) was performed using frequency models, combining all available direct and indirect evidence from RCTs.

Cyto-, gene, and multireceptor architecture of the early postnatal mouse hippocampal complex.

Neurotransmitter receptors are key molecules in signal transmission in the adult brain, and their precise spatial and temporal balance expressions also play a critical role in normal brain development. However, the specific balance expression of multiple receptors during hippocampal development is not well characterized. In this study, we used quantitative in vivo receptor autoradiography to measure the distributions and densities of 18 neurotransmitter receptor types in the mouse hippocampal complex at postnatal day 7, and compared them with the expressions of their corresponding encoding genes.

How Users' Personality Traits Predict Sentiment Tendencies of User-Generated Content in Social Media: A Mixed Method of Configuration Analysis and Machine Learning.

Objective: Social media content created by users with different personality traits presents various sentiment tendencies, easily leading to irrational public opinion. This study aims to explore the relationships between users' personality traits and sentiment tendencies of user-generated content (UGC).

Method: We crawled 18,686 tweets of 1, 215 users from Twitter to figure out the relationships between personality traits and sentiment tendencies.

Development of the Curcumin Analog CA7 Liposome and Its Evaluation for Efficacy Against Cervical Cancer in vitro and in vivo.

Objective: The objective of this study was to develop liposomes (LP) containing a curcumin (CU) analog CA7 to enhance its pharmacokinetic profile and anti-cervical cancer (CC) effects.

Methods: Single-factor and Box-Behnken experiments were conducted to optimize the formulation of CA7-loaded liposomes (CA7-LP). The in vitro release, stability, biocompatibility, and pharmacokinetic of CA7-LP were evaluated.

Study on the Microscopic Distribution Pattern of Residual Oil and Exploitation Methods Based on a Digital Pore Network Model.

With the persistent rise in global energy demand, the efficient extraction of petroleum resources has become an urgent and critical issue. Polymer flooding technology, widely employed for enhancing crude oil recovery, still lacks an in-depth understanding of the distribution of residual oil within the microscopic pore structure and the associated displacement mechanisms. To address this, a digital pore network model was established based on mercury intrusion experimental data, and pore structure visualization was achieved through 3Dmax software, simulating the oil displacement process under various polymer concentrations, molecular weights, and interfacial tension conditions.

Diagnosis of Fibrotic Interstitial Lung Diseases Based on the Combination of Label-Free Quantitative Multiphoton Fiber Histology and Machine Learning.

Interstitial lung disease (ILD), characterized by inflammation and fibrosis, often suffers from low diagnostic accuracy and consistency. Traditional hematoxylin and eosin (H&E) staining primarily reveals cellular inflammation with limited detail on fibrosis. To address these issues, we introduce a pioneering label-free quantitative multiphoton fiber histology (MPFH) technique that delineates the intricate characteristics of collagen and elastin fibers for ILD diagnosis.

Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study.

Objectives: Acupuncture is a promising therapy for amnestic mild cognitive impairment (aMCI). Growing evidence suggest that alterations in the microbiota-gut-brain (MGB) axis contribute to the development and progression of aMCI. However, little is known about whether and how acupuncture change the MGB axis of aMCI individuals.

Entropy-engineered perovskite cathodes: A novel approach for efficient and durable CO electrolysis.

The application of solid oxide electrolysis cells (SOECs) for high-temperature CO reduction reaction (CORR) is constrained by the electrochemical activity and stability of the cathode materials. In this study, a series of iron-based perovskite oxides, designed by systematically varying A-site configurational entropy, are investigated as cathode materials for the CORR. Experimental results reveal that these high-entropy materials, derived from LaSrFeO (LSF), exhibit high electrocatalytic activity and durability.

Comprehensive cultivation of the broiler gut microbiota guides bacterial isolation from chickens.

Chicken gut microbiota plays an important role in maintaining their physiological health. However, the cultivability of chicken gut microbiota is not well understood, limiting the exploration of certain key gut bacteria in regulating intestinal health and nutritional metabolism. This study aimed to examine the cultivability of chicken cecal microbiota and to provide guidance for future chicken gut microbiota cultivation.

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): and evaluation.

Chemotherapy remains the first choice of treatment for colon cancer despite the inevitable adverse effects. Curcumin (CU) possesses antitumor activity but has poor aqueous solubility, low bioavailability, and weak activity. To address this, nine novel monocarbonyl CU analogues were designed, synthesized, and evaluated in the present study.

A comparative meta-analysis of structural magnetic resonance imaging studies and gene expression profiles revealing the similarities and differences between late life depression and mild cognitive impairment.

Background: Late-life depression (LLD) predisposes individuals to cognitive decline, often leading to misdiagnoses as mild cognitive impairment (MCI). Voxel-based morphometry (VBM) can distinguish the profiles of these disorders according to gray matter (GM) volumes. We integrated findings from previous VBM studies for comparative analysis and extended the research into molecular profiles to facilitate inspection and intervention.

The analgesic effectiveness of auriculotherapy for acute postoperative pain: A systematic review and meta-analysis.

Background: Postoperative pain is a significant yet inadequately managed complication following surgery, and auriculotherapy to alleviate acute postoperative pain (APP) and reduce the use of opioids remains controversial.

Methods: We searched the MEDLINE, Web of Science, Embase, Cochrane Library, CINAHL Complete, and ClinicalTrials.gov from inception to January 23, 2024 for all randomized controlled trials (RCTs) of auriculotherapy in the treatment of APP.

Enhancing catalytic efficiency of GAO-5F from Fusarium odoratissimum and its application in development of a polyaldehyde crosslinked gelatin-based edible packaging film.

Galactose oxidase has long captured the interest of the biocatalysis and biotechnology communities due to its unique catalytic characteristics and versatility with various substrates. In our previous studies, we demonstrated that galactose oxidase GAO-5F from Fusarium odoratissimum can oxidize agarose to produce a polyaldehyde polymer, which can be further crosslinked with gelatin to produce food packaging films. Despite its commendable catalytic performance, GAO-5F falls short of meeting the requirements for industrial applications.

Polar solvent vapor annealing enhanced optoelectronic properties of solution-processed exciplex organic light-emitting diodes.

Exciplex organic light-emitting diodes (OLEDs) are widely utilized for their high internal quantum efficiency. Although solution-processed devices offer the advantages of simple operation and low cost, few studies have reported on the preparation of exciplex OLED devices using solution methods. This paper presents exciplex OLEDs produced between m-MTDATA and Bphen, fabricated using a solution method and optimized by a polar solvent vapor annealing (PSVA) treatment.