CPA4 overexpression correlates with poor prognosis and tumor progression in endometrial cancer.

Background: The rise in endometrial cancer rates globally calls for advanced diagnostic methods and new biomarkers. CPA4, known for its role in cancer development, has not yet been studied in relation to endometrial cancer, making it a promising research avenue.

Methods: We analyzed CPA4's mRNA expression using data from TCGA and GEO databases and validated these findings with 116 clinical samples through immunohistochemical analysis.

Antioxidant and anticancer properties of fucoidan isolated from Saccharina Japonica brown algae.

Fucoidan is a fucose-rich sulfated polysaccharide that has gained attention owing to its various biological activities. In this study, fucoidan was isolated from Saccharina japonica using an enzyme-assisted method, and its antioxidant and anti-hepatocarcinoma effects were evaluated. The fucoidan was a 112.

Biosilicification-mimicking chiral nanostructures for targeted treatment of inflammatory bowel disease.

The cascade reaction of lipopolysaccharides (LPS), cell-free DNA (cfDNA), and reactive oxygen species (ROS), drives the development of inflammatory bowel disease (IBD). Herein, we construct polyethylenimide (PEI)-L/D-tartaric acid (L/D-TA) complexes templated mesoporous organosilica nanoparticles (MON) (PEI-L/D-TA@MON) by mimicking biosilicification under ambient conditions within seconds. The chiral nanomedicines include four functional moieties, wherein PEI electrostatically attracts cfDNA, tetrathulfide bonds reductively react with ROS, silanol groups adsorb LPS, and L/D-TA enables chiral recognition and inflammatory localization.

Task-augmented cross-view imputation network for partial multi-view incomplete multi-label classification.

In real-world scenarios, multi-view multi-label learning often encounters the challenge of incomplete training data due to limitations in data collection and unreliable annotation processes. The absence of multi-view features impairs the comprehensive understanding of samples, omitting crucial details essential for classification. To address this issue, we present a task-augmented cross-view imputation network (TACVI-Net) for the purpose of handling partial multi-view incomplete multi-label classification.

Scale-Adaptive viable tumor burden estimation via histopathological microscopy image segmentation.

Cancer segmentation in whole-slide images is a fundamental step for estimating tumor burden, which is crucial for cancer assessment. However, challenges such as vague boundaries and small regions dissociated from viable tumor areas make it a complex task. Considering the usefulness of multi-scale features in various vision-related tasks, we present a structure-aware, scale-adaptive feature selection method for efficient and accurate cancer segmentation.

Best practice guidelines and service provision for supporting women with birth-related trauma: A scoping review of international literature.

Problem: Birth trauma (BT) is a significant public health concern affecting approximately one-third of the 140 million annual births worldwide, yet it lacks a unified approach for effective intervention. This study investigates the global landscape of BT management, focusing on the current best practice guidelines and service provisions for supporting women with birth-related trauma and the practicable actionable gaps that needs to be addressed.

Methods: This scoping review followed the PRISMA Extension for Scoping Reviews guidelines, and systematically searched 13 electronic databases and websites for clinical guidelines, policy documents, care standards, practice recommendations and service provisions related to BT.

Lasting impacts of rapid salinity change on physiological energetics of estuarine oysters (Crassostrea hongkongensis).

The duration of rapid salinity change (RSC) prevailing in estuarine and coastal regions is increasing due to extreme climate and weather events, posing significant challenges to marine bivalves. The Hong Kong oyster (Crassostrea hongkongensis), an ecologically and economically important species in tropical estuarine ecosystems, has experienced increasing mass mortality during prolonged periods of RSC, yet little is known about underlying physiological processes. Here, we investigated how physiological energetics of C.

Nickel-based nanomaterials: a comprehensive analysis of risk assessment, toxicity mechanisms, and future strategies for health risk prevention.

Nickel-based nanomaterials (NBNs) have seen a surge in usage across a variety of applications. However, the widespread use of NBNs has led to increased human exposure, raising questions about their associated health risks, both in the short and long term. Additionally, the spread of NBNs in the environment has attracted considerable attention, emerging as a vital focus for research and development.

Nucleus pulposus cell-mimicking nanoparticles for cell-specific HIF1A editing to modulate SASP-mediated disc inflammation via autophagy activation.

Traditional methods of plasmid delivery, including viral vectors, lipofection, and electroporation, are widely used for gene editing but have limitations, such as cellular toxicity, limited transfection efficiency in primary cells, and nonspecific side effects. Here, we report the development of nucleus pulposus cell (NPC)-mimicking nanoparticles (HIF1A@NNP) with an NPC membrane as the shell and pcDNA3.1-rHIF1A encapsulated in the core via extrusion.

Predicting Severe Radiation Pneumonitis in Patients With Locally-Advanced Non-Small-Cell Lung Cancer After Thoracic Radiotherapy: Development and Validation of a Nomogram Based on the Clinical, Hematological, and Dose-Volume Histogram Parameters.

Purpose: This study aimed to investigate the risk factors for severe radiation pneumonitis (RP) after thoracic radiotherapy (RT) in patients with locally advanced non-small cell lung cancer (NSCLC), develop a prediction model to identify high-risk groups, and investigate the impact of severe RP on overall survival (OS).

Methods: We retrospectively collected clinical, dosimetric, and hematological factors of patients with stage III NSCLC receiving thoracic RT without immunotherapy. The primary and secondary end points were severe RP and OS, respectively.

Casein kinase GhCKA1 positively regulates cotton resistance to Verticillium wilt.

Verticillium wilt is an important disease that seriously affects the quality and yield of cotton. Fungal vascular diseases caused by Verticillium dahliae hinders the sustainable development of cotton cultivation. The most effective strategy for managing Verticillium wilt in cotton involves identifying resistance genes, investigating resistance mechanisms, and developing resistant varieties.

Transcriptomic and metabolic profiling reveals the effects of long-term microwave exposure on testicular tissue.

The effect of electromagnetic exposure on health is becoming increasingly important as it affects many aspects of human life and health. However, the effects in environmental electromagnetic fields on the male reproductive system were still controversial, and the impacts of long-term microwave exposure on testicular tissue remain poorly defined. This study exposed rats to 30 mW/cm of microwave radiation (2.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

A multimodal defect-rich nanoreactor triggers sono-piezoelectric tandem catalysis and iron metabolism disruption for implant infections.

Tracking and eradicating drug-resistant bacteria are critical for combating implant-associated infections, yet effective antibacterial therapies remain elusive. Herein, we propose an oxygen vacancy-rich (BiFe)(BaTi)O nanoreactor as a piezoelectric sonosensitizer by spatiotemporal ultrasound-driven sono- and chemodynamic tandem catalysis to amplify antibacterial efficacy. The piezoelectric charge carriers under a built-in electric field synchronize the reaction of O and HO, efficiently generating HO.

Optimization design and experiment of key components of mountain pendulum-lever cam type hole seeders based on DEM-MBD coupling simulation.

In response to issues such as high miss-seeding rates and uneven seed grain distribution during the operation of the pendulum-lever camshaft hole seeders under the compound planting mode of corn and soybeans in hilly mountainous areas, a method for optimizing the hole seeders by adjusting movable pendulum-lever angle and the number of cam roller groups is proposed. By analyzing the motion process and mechanism of hole formation of the hole-forming device, it was possible to elucidate the influence of the movable pendulum-lever angle and cam roller group number on the improvement of seeding quality. Based on the DEM-MBD coupled simulation, single-factor simulation experiments were conducted using the hole seeders shaft speed, movable pendulum- lever angle, and cam roller group number as test factors, with the seed grain qualification rate, reseeding rate, and miss-seeding rate as test indicators.

177Lu-LNC1004 Radioligand Therapy in Patients with End-stage Metastatic Cancers: A Single-Center, Single-Arm, Phase II Study.

Purpose: Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts and certain tumor cells, making it a promising therapeutic target for various malignancies. This study evaluated the efficacy and safety of 177Lu-Evans blue-FAP inhibitor (177Lu-LNC1004) radioligand therapy (RLT) for treating end-stage metastatic tumors.

Patients And Methods: This single-arm, single-center, phase II trial included 28 patients with progressive metastatic malignancies (11 types) and high FAP expression (defined as a maximum standardized uptake value ≥10 in >50% of tumors) who had exhausted all approved therapies, screened between June 2022 and April 2024.

Associations Between Social Support, Health Literacy and Psychological Resilience to Self-Management Behaviours in Liver Transplant Recipients-A Structural Equation Model.

Aims: This study aimed to develop a structural model to elucidate the contributions of social support, health literacy and psychological resilience to self-management behaviours in liver transplant recipients after surgery.

Design: Cross-sectional study.

Methods: This study included 215 Chinese patients who returned to the outpatient department after liver transplantation between June 2023 and March 2024.

Consumer Experiences of the Australian Stepped Care Model in Primary Mental Health Care: A Qualitative Study.

Mental illness remains a significant public health challenge in Australia, affecting nearly half of the adult population and placing a considerable strain on the healthcare system. The Australian government has implemented the Stepped Care Model (SCM) within primary mental health care to address this issue to improve service access, efficiency, and outcomes. This study explores the experiences of nine consumers (also referred to as patients) who received care under the SCM, focusing on their perspectives on accessing and navigating mental health services.

TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma.

: TFEB activation is associated with prolonged survival in LUAD patients, suggesting potential benefits of TFEB agonists in LUAD treatment. In this study, we identify ginkgetin (GK), derived from , as a natural TFEB agonist, which has demonstrated promising anticancer effects in our previous research. TFEB activation has been shown to promote GPX4 degradation, inducing ferroptosis; however, the specific E3 ligases, deubiquitinating enzymes (DUBs), and types of polyubiquitination chains involved remain unclear.

Investigation on the pro-aroma generation effects of fatty acids in beef via thermal oxidative models.

Fatty acids (FAs) in lipids are important precursors for the formation of meat aroma compounds. However, the specific roles of individual FAs and related reactions in beef aroma formation remain unclear. This study established thermal oxidation models to investigate the impact of different FAs on the formation of beef aroma compounds.

eNAMPT/Ac-STAT3/DIRAS2 Axis Promotes Development and Cancer Stemness in Triple-Negative Breast Cancer by Enhancing Cytokine Crosstalk Between Tumor-Associated Macrophages and Cancer Cells.

The intricate relationship between tumor-associated macrophages (TAMs) and cancer cells is pivotal for carcinogenesis, with TAMs being integral to the tumor microenvironment (TME). This study explores the novel mechanisms by which TAMs regulate the progression of triple-negative breast cancer (TNBC) within the TME. Using a co-culture system and methodologies such as cytokine arrays, proteomics, and CRISPR-Cas9, we investigated the crosstalk between TAMs and TNBC cells.

Burden of silicosis based on the Global Burden of Disease Study 2021: trend analysis of incidence, mortality, and disability-adjusted life years, and projections for the next 30 years.

Background: Silicosis, an occupational disease caused by chronic silica exposure, has a high global burden and limited treatment options. This study analyzed the epidemiological trends and future projections of silicosis based on data from the Global Burden of Disease (GBD), aiming to provide data support for public health interventions.

Methods: We extracted and analyzed the data on the incidence, mortality, and disability-adjusted life years (DALYs) of silicosis, as well as the age-standardized rate (ASR) of silicosis from the GBD Study 2021.

COVID-19 caused by the Omicron variant in lung transplant recipients: a single center case series.

Background: Although coronavirus disease 2019 (COVID-19) is no longer classified as a Public Health Emergency of International Concern by World Health Organization, its global impact persists. Data on its impact in lung transplant recipients (LTRs) from China remain limited. This study aims to share clinical experiences and provide insights into managing LTRs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Melatonin protects retinal pigment epithelium cells against ferroptosis in AMD via the PI3K/AKT/MDM2/P53 pathway.

Introduction: Oxidative stress-prompted degeneration of the retinal pigment epithelium (RPE) notably contributes to the onset of age-related macular degeneration (AMD). However, the pathways leading to RPE deterioration and possible preventative strategies are not yet completely comprehended.

Methods: Ferroptosis was assayed through the evaluation of lipid peroxidation (C11-BODIPY and MDA), reactive oxygen species (ROS), transmission electron microscopy (TEM), iron content measurement, q-PCR, western blotting, and immunofluorescence.

The role of lncRNAs in AKI and CKD: Molecular mechanisms, biomarkers, and potential therapeutic targets.

Exosomes, a type of extracellular vesicle, are commonly found in different body fluids and are rich in nucleic acids (circRNA, lncRNAs, miRNAs, mRNAs, tRNAs, .), proteins, and lipids. They are involved in intercellular communication.