Decoupling the air sensitivity of Na-layered oxides.

Air sensitivity remains a substantial barrier to the commercialization of sodium (Na)-layered oxides (NLOs). This problem has puzzled the community for decades because of the complexity of interactions between air components and their impact on both bulk and surfaces of NLOs. We show here that water vapor plays a pivotal role in initiating destructive acid and oxidative degradations of NLOs only when coupled with carbon dioxide or oxygen, respectively.

Overcoming Kinetic Limitations of Polyanionic Cathode toward High-Performance Na-Ion Batteries.

Polyanionic cathodes have attracted extensive research interest for Na-ion batteries (NIBs) due to their moderate energy density and desirable cycling stability. However, these compounds suffer from visible capacity fading and significant voltage decay upon the rapid sodium storage process, even if modified through nanoengineering or carbon-coating routes, leading to limited applications in NIBs. Herein, the Na(VOPO)F cathode material with dominantly exposed {001} active facets is demonstrated by a topochemical synthesis route.

CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells.

Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that contributes to the development of age-related macular degeneration (AMD), a pivotal factor leading to permanent vision impairment. Long non-coding RNAs (lncRNAs) have emerged as critical regulators orchestrating EMT in RPE cells. In this study, we explored the function of the lncRNA CYTOR (cytoskeleton regulator RNA) in EMT of RPE cells and its underlying mechanisms.

Effects of the Supplementation of Essential Oil Mixtures on Growth Performance, Nutrient Digestibility, Immune Status and Microbial Community in Weaned Piglets.

Since essential oils-such as cinnamaldehyde, thymol, carvacrol, and eugenol-have antibacterial, antioxidant, and anti-inflammatory properties, this study aimed to examine the supplementation of different essential oil mixtures together with 1600 mg/kg zinc oxide (ZnO) on growth performance, incidence of diarrhea, serum immune indices, fecal volatile fatty acids, and microflora structure in weaned piglets. A total of 240 weaned piglets (Duroc × Landrace × Yorkshire) with an average body weight of 8.85 ± 0.

Polyanionic Cathode Materials for Practical Na-Ion Batteries toward High Energy Density and Long Cycle Life.

Na-ion batteries (NIBs) as a supplement to Li-ion batteries deliver huge application potential in the field of grid-scale energy storage. At present, it is a particularly imperative to advance commercialization of the NIBs after ten years of intensive research. Among the exploited cathodes for NIBs, polyanionic compounds have great commercial prospects due to their favorable ion diffusion channels, high safety, and superior structure stability determined by their unique structure framework; however, there is still a long way to go before large-scale industrialization can be realized.

Surface Engineering Stabilizes Rhombohedral Sodium Manganese Hexacyanoferrates for High-Energy Na-Ion Batteries.

The rhombohedral sodium manganese hexacyanoferrate (MnHCF) only containing cheap Fe and Mn metals was regarded as a scalable, low-cost, and high-energy cathode material for Na-ion batteries. However, the unexpected Jahn-teller effect and significant phase transformation would cause Mn dissolution and anisotropic volume change, thus leading to capacity loss and structural instability. Here we report a simple room-temperature route to construct a magical Co B skin on the surface of MnHCF.

Case report: A rare case of acute myeloid leukemia with CPSF6-RARG fusion resembling acute promyelocytic leukemia.

( gene rearrangement has been reported in several acute myeloid leukemia (AML) patients. They resemble classical acute promyelocytic leukemia (APL) patients in clinical features, morphology, and immunophenotype but do not carry the () fusion gene. Importantly, almost all these APL-like AML patients show resistance to all-trans retinoic acid (ATRA), and no effective treatment is recommended for them.

Reinforced erythroid differentiation inhibits leukemogenic potential of t(8;21) leukemia.

Oncoprotein AML1-ETO (AE) derived from t(8;21)(q22;q22) translocation is typically present in a portion of French-American-British-M2 subtype of acute myeloid leukemia (AML). Although these patients have relatively favorable prognoses, substantial numbers of them would relapse after conventional therapy. Here, we explored whether reinforcing the endogenous differentiation potential of t(8;21) AML cells would diminish the associated malignancy.

Preparation and Characterization of Screen-Printed CuS/PEDOT:PSS Hybrid Films for Flexible Thermoelectric Power Generator.

In recent years, flexible thermoelectric generators(f-TEG), which can generate electricity by environmental temperature difference and have low cost, have been widely concerned in self-powered energy devices for underground pipe network monitoring. This paper studied the CuS films by screen-printing. The effects of different proportions of p-type CuS/poly 3,4-ethylene dioxythiophene-polystyrene sulfonate (PEDOT:PSS) mixture on the thermoelectric properties of films were studied.

Regulated Synthesis of α-NaVOPO with an Enhanced Conductive Network as a High-Performance Cathode for Aqueous Na-Ion Batteries.

The low-cost and profusion of sodium reserves make Na-ion batteries (NIBs) a potential candidate to lithium-ion batteries for grid-scale energy storage applications. NaVOPO has been recognized as one of the most promising cathodes for high-energy NIBs, owing to their high theoretical capacity and energy density. However, their further application is hindered by the multiphase transition and conductivity confinement.

Effect of gut microbiota from Henoch-Schönlein Purpura patients on acid-sensitive ion channel 3 expression and intestinal motility in germ-free rats.

Background: It has been proven that gut microbiota alterations are involved in the development of Henoch-Schönlein Purpura (HSP). However, the pathogenesis of HSP hasn't been eluciated. This study was to investigate the impact of gut microbiota from HSP on ASIC3 expression and interactions between microbiota and ASIC3 expression in the development of HSP.

O3-NaFeNiMnAlO Cathodes with Improved Air Stability for Na-Ion Batteries.

Na-ion batteries (NIBs) have been considered as potential candidates for large-scale energy storage, where O3-type Na-based layered oxide cathodes have attracted great attention due to their high capacity and low cost. However, O3-NaTMO materials still suffer from insufficient air stability, which could lead to deteriorative electrochemical properties and thus hinder their practical application. In this work, a series of Al-doped O3-NaFeNiMnAlO cathodes prepared by a co-precipitation method were investigated to enhance their electrochemical performance and air stability through stabilizing their structural and interface chemical properties.

Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-α Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.

Objectives: The objective of this study is to examine the role of the tumour necrosis factor-α converting enzyme-epidermal growth factor receptor (TACE-EGFR) pathway in human neutrophil elastase (HNE)-induced MUC5AC mucin expression in mice.

Method: Four groups of mice, treated with HNE alone (HNE group), HNE plus TACE inhibitor (HNE + TAPI-2 group), HNE plus EGFR inhibitor (HNE + AG1478 group), and untreated (control group), were used in the experiment. Histopathological changes were monitored by haematoxylin-eosin (HE) and periodic acid-Schiff (PAS) staining.

Rapid mechanochemical synthesis of polyanionic cathode with improved electrochemical performance for Na-ion batteries.

Na-ion batteries have been considered promising candidates for stationary energy storage. However, their wide application is hindered by issues such as high cost and insufficient electrochemical performance, particularly for cathode materials. Here, we report a solvent-free mechanochemical protocol for the in-situ fabrication of sodium vanadium fluorophosphates.

Influence of feeding thermally peroxidized lipids on growth performance, lipid digestibility, and oxidative status in nursery pigs.

Three experiments were conducted to evaluate oil source and peroxidation status (experiment 1) or peroxidized soybean oil (SO; experiments 2 and 3) on growth performance, oxidative stress, and digestibility of dietary ether extract (EE). In experiment 1, palm oil (PO), poultry fat (PF), canola oil (CO), and SO were evaluated, while in experiments 2 and 3, only SO was evaluated. Lipids were either an unheated control (CNT) or thermally processed at 90 °C for 72 hr, being added at 10%, 7.

Revisiting of Tetragonal NaVPOF: A High Energy Density Cathode for Sodium-Ion Batteries.

Tetragonal NaVPOF has been regarded as an ideal cathode for sodium-ion batteries because of its high average plateau (3.8 V) and theoretical specific capacity (143 mA h g). However, the Na-storage performance is still hindered by unsatisfying thermal stability and poor conductivity.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation.

Retinoic acid-inducible gene I (RIG-I) is up-regulated during granulocytic differentiation of acute promyelocytic leukemia (APL) cells induced by all- retinoic acid (ATRA). It has been reported that RIG-I recognizes virus-specific 5'-ppp-double-stranded RNA (dsRNA) and activates the type I interferons signaling pathways in innate immunity. However, the functions of RIG-I in hematopoiesis remain unclear, especially regarding its possible interaction with endogenous RNAs and the associated pathways that could contribute to the cellular differentiation and maturation.

Selective recovery of Li and FePO from spent LiFePO cathode scraps by organic acids and the properties of the regenerated LiFePO.

To recycle the sharply growing spent lithium-ion batteries and alleviate concerns over shortages of resources, particularly Li, is still an urgent issue. In this work, an organic acids based leaching approach at room temperature is proposed to recover Li and FePO from spent LiFePO cathode powder. The coexistent metal ions, Cu and Al, have also been investigated.

MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice.

Background: Skeletal muscle is the largest tissue in the human body, and it plays a major role in exerting force and maintaining metabolism homeostasis. The role of muscle transcription factors in the regulation of metabolism is not fully understood. MondoA is a glucose-sensing transcription factor that is highly expressed in skeletal muscle.

Retinoic acid inducible gene-I slows down cellular senescence through negatively regulating the integrin β3/p38 MAPK pathway.

Retinoic acid inducible gene-I (Rig-I) has been well documented as a cytosolic pattern recognition receptor that can sense viral RNA ligands to initiate the interferon-mediated antiviral immunity. However, little is known about the biological behaviors of Rig-I devoid of viral infection. Herein, we investigated the roles of Rig-I in the regulation of cellular senescence.