Integrated Analysis of Single-Cell and Bulk RNA Sequencing Reveals HSD3B7 as a Prognostic Biomarker and Potential Therapeutic Target in ccRCC.

Clear cell renal cell carcinoma (ccRCC) is the most common kidney malignancy, with a poor prognosis for advanced-stage patients. Identifying key biomarkers involved in tumor progression is crucial for improving treatment outcomes. In this study, we employed an integrated approach combining single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (bulk RNA-seq) to identify biomarkers associated with ccRCC progression and prognosis.

Resveratrol Alleviates Fumonisin B1-Induced Cytotoxicity in Sertoli Cells.

Fumonisin B1 is a common food contaminant that has been found to adversely affect the reproductive system, especially Sertoli cells. However, the potential mitigation of FB1-induced cytotoxicity in Sertoli cells has not been fully elaborated. Resveratrol is a natural substance with anti-inflammatory, antioxidant, and anti-tumor properties.

Dual-targeted and esterase-responsive cyclodextrin-based host-guest nanocomposites for enhanced antitumor therapy.

Conventional chemotherapy drugs are difficult to effectively target tumor tissue, leading to poor treatment outcomes and side effects. Actively targeted and stimuli-responsive nanomedicine greatly improves this situation, allowing for more precise drug accumulation at tumor sites. Herein, carboxymethyl-β-cyclodextrin (CMCD) - based host-guest nanocomposites (NPs) encapsulating hydroxycamptothecin (HCPT) were fabricated, which responded to esterase and had the function of targeting CD 44 receptors and the nucleus.

Study of particle equilibrium based on the combination of light-actuated AC electroosmosis and light-actuated dielectrophoresis.

Optoelectronic tweezers (OETs) represent a flexible, high-throughput method for manipulating micro/nano particles or cells. This technique involves not only light-actuated dielectrophoresis (LDEP) but also light-actuated AC electroosmosis (LACE), which occurs concurrently in OETs devices. Despite this, the combination of negative LDEP and LACE has been relatively unexplored in previous research.

Research on Activation Mechanisms In Situ during Rapid Desorption of Mercury-Absorbing Activated Coke by the Heating Method.

The adsorption of active coke is a good method to control mercury in coal-fired power plants, but spent powdered activated coke (SPAC) will cause secondary pollution and waste of resources if it is not properly treated. The purpose of this study was to explore the desorption performance of SPAC when heated in a drop-tube reactor under different atmospheres. The carbon consumption was 0.

Reasons for the continued decline in fertility intentions: explanations from overtime work.

China's fertility rate continues to decline despite government fertility policies. This study aims to explore the micro-level causes of China's declining fertility rate by examining the impact of changes in Chinese work patterns in recent years, particularly the prevalence of overtime work, on fertility intentions. Using data from the China Family Panel Studies (CFPS), this study examines the impact of overtime work on fertility intentions at both the provincial and urban levels.

Levels of Asymmetric Dimethylar Ginine and Risk of Neurovascular Diseases: A Systematic Review and Meta-Analysis.

Scope: The purpose of this study was to provide clear evidence that reliably quantifies the association of Asymmetric dimethylarginine (ADMA) levels with the risk of neurovascular diseases.

Methods And Results: The Pubmed, Web of Science, and Embase were systematically searched to identify eligible studies published until August 2024. A total of 31 eligible studies were identified.

Syntheses, structures and characterization of noncentrosymmetric MZnPO (M = K, NH).

Two phosphates, KZnPO and NHZnPO, were successfully synthesized using a solid-state reaction method and characterized single-crystal X-ray diffraction. Both of their structures feature a three-way skeleton composed of isolated PO and ZnO tetrahedra, with K/NH cations occupying the spaces within the frameworks to balance charges. These compounds are isostructural and crystallize in the noncentrosymmetric 6 space group.

Associations between Wastewater Microbiome and Population Smoking Rate Identified Using Wastewater-Based Epidemiology.

Tobacco use is known to cause health damage, partly by changing the mouth, respiratory tract, and gut-related microbiomes. This study aims to identify the associations between the human microbiome detected in domestic wastewater and the population smoking rate. Metagenomic sequencing and a biomarker discovery algorithm were employed to identify microorganisms as potential microbial biomarkers of smoking through wastewater-based epidemiology.

In Situ Crystallized Ceria-Vesicle Nanohybrid Therapeutic for Effective Treatment of Inflammatory Intraocular Disease.

Posterior uveitis is a leading cause of vision impairment and blindness globally due to its detrimental effects on the choroid and retina. The condition is worsened by oxidative stress, which heightens inflammation and perpetuates a cycle of damage that current treatments only temporarily relieve. To address this, a novel treatment involving the in situ crystallization of ultrasmall cerium oxide nanoparticles (≈3 nm) on mesenchymal stem cell (MSC) extracellular vesicles (EVs) for the management of primed mycobacterial uveitis (PMU) is developed.

Structural evolution and catalytic mechanisms of perovskite oxides in electrocatalysis.

Electrocatalysis plays a pivotal role in driving the progress of modern technologies and industrial processes such as energy conversion and emission reduction. Perovskite oxides, an important family of electrocatalysts, have garnered substantial attention in diverse catalytic reactions because of their highly tunable composition and structure, as well as their considerable activity and stability. This review delves into the mechanisms of electrocatalytic reactions that use perovskite oxides as electrocatalysts, while also providing a comprehensive summary of the potential key factors that influence catalytic activity across various reactions.

Strategic engineering of cationic systems for spatial & temporal anti-counterfeiting applications in zero-dimensional Mn(II) halides.

While spatial and time-resolved anti-counterfeiting technologies have gained increasing attention owing to their excellent tunable photoluminescence, achieving high-security-level anti-counterfeiting remains a challenge. Herein, we developed a spatial-time-dual-resolved anti-counterfeiting system using zero-dimensional (0D) organic-inorganic Mn(II) metal halides: (EMMZ)MnBr (named M-1, EMMZ=1-Ethyl-3-Methylimidazolium Bromide) and (EDMMZ)MnBr (named M-2, EDMMZ=1-Ethyl-2,3-Dimethylimidazolium Bromide). M-1 shows a bright green emission with a quantum yield of 78 %.

PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders.

Adipose tissue macrophages (ATMs) play important roles in maintaining adipose tissue homeostasis and orchestrating metabolic inflammation. Given the extensive functional heterogeneity and phenotypic plasticity of ATMs, identification of the authentically pathogenic ATM subpopulation under obese setting is thus necessitated. Herein, we performed single-nucleus RNA sequencing (snRNA-seq) and unraveled a unique maladaptive ATM subpopulation defined as ATF4PDIA3ACSL4CCL2 inflammatory and metabolically activated macrophages (iMAMs), in which PDIA3 is required for the maintenance of their migratory and pro-inflammatory properties.

Sorafenib-mediated cleavage of p62 initiates cellular senescence as a mechanism to evade its anti-hepatocellular carcinoma efficacy.

Hepatocellular carcinoma (HCC) stands as one of the most aggressively advancing and lethal malignancies. Sorafenib is presently endorsed as a primary therapy for advanced liver cancer, but its resistance presents a formidable challenge. Previous studies have implicated a connection between post-sorafenib discontinuation rebound and the development of drug resistance, yet the underlying mechanism remains elusive.

Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in Lacrimal Gland Adenoid Cystic Carcinoma.

Purpose: We assessed whether NICD1 expression, c-MYC expression, and P63 expression by immunohistochemistry (IHC) correlate with prognosis and high-risk clinicopathological features in lacrimal gland adenoid cystic carcinoma (ACC).

Methods: Records of patients with lacrimal gland ACC who underwent surgery between 1998 to 2018 were reviewed. Clinicopathologic and treatment data were collected.

Adverse event reporting of the IGF-1R monoclonal antibody teprotumumab: a real-world study based on the US food and drug administration adverse event reporting system.

Background: Teprotumumab, an IGF-1R monoclonal antibody, has shown significant efficacy in treating thyroid eye disease (TED). However, since teprotumumab was launched in 2020 and first approved in the United States, there were limited reports of post-marketing adverse events (AEs). In this study, we aimed to mine and analyze the AEs signals with teprotumumab on the basis of the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) to provide instructions in clinical practice concerning adverse reactions and assistance in drug development and import/export into other countries.

Molybdenum Disulfide Induced Phase Control Synthesis of Multi-dimensional CoS-MoS Heteronanostructures via Cation Exchange.

Phase control over cation exchange (CE) reactions has emerged as an important approach for the synthesis of nanomaterials (NMs), enabling precise determination of their reactivity and properties. Although factors such as crystal structure and morphology have been studied for the phase engineering of CE reactions in NMs, there remains a lack of systematic investigation to reveal the impact for the factors in heterogeneous materials. Herein, we report a molybdenum disulfide induced phase control method for synthesizing multidimensional CoS-MoS heteronanostructures (HNs) via cation exchange.

Capacitive Low-Frequency Hydrophone Based on Micronanostructured Iontronic Hydrogel for Underwater Monitoring.

Hydrophones play a crucial role in underwater target detection within sonar systems. However, existing hydrophones often encounter challenges such as low sensitivity and poor signal-to-noise ratio (SNR) in the detection of low-frequency acoustic signals. This work introduces a capacitive hydrophone (CH) designed for highly sensitive detection of low-frequency underwater sound signals.

TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1.

Sepsis is a common complication of infections that significantly impacts the survival of critically patients. Currently, effective pharmacological treatment strategies are lacking. Auranofin, known as an inhibitor of Thioredoxin reductase (TrxR), exhibits anti-inflammatory activity, but its role in sepsis is not well understood.

Development of a diagnostic model for biliary atresia based on MMP7 and serological tests using machine learning.

Objective: To develop a machine learning diagnostic model based on MMP7 and other serological testing indicators for early and efficient diagnosis of biliary atresia (BA).

Methods: A retrospective analysis was conducted on patient information from those hospitalized for pathological jaundice at Beijing Children's Hospital between January 1, 2019, and December 31, 2023. Patients with serum MMP7, liver stiffness measurements, and other routine serological tests were included in the study.