Postoperative adjuvant therapy for stage IA-IIA cervical adenocarcinoma (FIGO 2018) with one intermediate-risk factor: a multicentre retrospective cohort study of 63,926 cases.

Objective: To compare the 5-year oncological outcomes of different adjuvant treatment modalities in patients with FIGO 2018 stage IA-IIA cervical adenocarcinoma who underwent open radical hysterectomy and one intermediate-risk pathological factor.

Methods: Based on the Four C database (between 2004 and 2018,n=63,926), patients with FIGO 2018 stage IA-IIA cervical adenocarcinoma and only one intermediate-risk pathological factor underwent open extensive hysterectomy. All patients were divided into three groups, namely, the simple surgery group (radical hysterectomy, RH), postoperative adjuvant chemotherapy group (radical hysterectomy and chemotherapy, RH + CT), and postoperative adjuvant chemoradiotherapy group (radical hysterectomy and radiotherapy/concurrent chemoradiotherapy, RH + RT/CCRT).

Phosphorus addition mitigates the combined negative effects of high temperature and nitrogen stress on corals.

Global warming and imbalances in nitrogen (N)-phosphorus (P) ratios due to increased human activity have had significant impacts on coral reef ecosystems. However, the underlying mechanisms of these impacts remain poorly understood. In this study, a controlled experiment was conducted on Acropora hyacinthus treated with different P concentrations at high temperature (30 °C) and high N level (9 μM nitrate), which was analyzed in terms of physical observations and physiological indices, as well as photosynthetic activity and fatty acid composition.

Association between the ratio of serum uric acid to high density lipoprotein cholesterol and depressive symptoms in middle-aged and elderly Chinese.

Background: Previous studies have reported that metabolic syndrome is associated with depression. In recent years, the ratio of uric acid to high-density lipoprotein cholesterol (UHR) has been considered as a new effective marker of metabolic syndrome. The purpose of this study was to investigate the association between UHR and depression in people aged 45 years and older in China using the China Health and Retirement Longitudinal Study(CHARLS) database.

Pollution characteristics, spatial variation, and ecological risks of phthalate esters in seawater and sediment from nine estuaries and their adjacent areas of Hainan Island, China.

Phthalate esters (PAEs) are omnipresent emerging contaminants, garnering increasing public attention. Nevertheless, the occurrence and potential risks of PAEs in tropical estuarine and coastal regions remain largely unexplored. This study investigated the occurrence, spatial distribution, and ecological risks of 12 PAEs in seawater and sediment samples collected from 9 estuaries and their adjacent areas around Hainan Island.

Cartilage-bioinspired tenacious concrete-like hydrogel verified via in-situ testing.

Polyvinyl alcohol (PVA)/polyethylene glycol (PEG) hydrogels, being low-cost and abundant materials, can demonstrate tremendous potential in applications requiring mechanical robustness by harnessing the enhancements afforded by a structure inspired by articular cartilage (AC). This study presents the fabrication of bioinspired PVA/PEG (BPP) hydrogel, characterized by their high mechanical strength and low friction coefficient. By utilizing a concrete-like structure composed of PVA particles and PVA/PEG fibers, the BPP hydrogel demonstrates notable properties such as high compressive strength (86%, 29.

Safety and Efficacy of Intra-Arterial Chemotherapy Combined With Immune Checkpoint Inhibitors in the Treatment of Advanced Head and Neck Squamous Cell Carcinoma.

Objective: To investigate the efficacy and safety of local intra-arterial chemotherapy combined with immune checkpoint inhibitors in the treatment of unresectable head and neck squamous cell carcinoma (HNSCC).

Methods: A retrospective analysis was conducted on the clinical data of eight patients diagnosed with unresectable HNSCC at our hospital from January to December 2023. All patients were diagnosed by pathological diagnosis and treated with intra-arterial chemotherapy combined with immune checkpoint inhibitors.

Towards sustainable maritime management: A re-visit of ammonia criterion values in Southeast Asian tropical seas.

The maritime industry's shift towards ammonia as a low-carbon fuel demands a re-evaluation of environmental criteria, especially in biodiverse and yet data-sparse Southeast Asian tropical seas. To fill the knowledge gap, this study proposes an updated set of ammonia criterion values for these marine environments, detailing the development process, assumptions, and limitations. Utilizing the widely used species sensitivity distributions with over 50 regionally relevant species, the study estimates criterion values for ammonia in Southeast Asian tropical seas.

The surgical technique and efficacy of a novel pure retroperitoneoscopic extravesical bladder cuff excision without intraoperative repositioning for upper tract urothelial carcinoma.

To evaluate the feasibility, effectiveness and therapeutic outcomes of a novel pure retroperitoneoscopic extravesical bladder cuff excision (PREBE) in patients with upper tract urothelial carcinoma (UTUC), a retrospectively comparative study between PREBE and traditional laparoscopic nephroureterectomy (TLNU) was done in a single center. We retrospectively evaluated 72 patients diagnosed with UTUC at our hospital from January 2022 to January 2024. The patients who underwent TLNU (n = 35) and PREBE (n = 37) were consecutively enrolled.

A 10-meter resolution dataset of abandoned and reclaimed cropland from 2016 to 2023 in Inner Mongolia, China.

Amid growing global food security concerns and frequent armed conflicts, real-time monitoring of abandoned cropland is essential for strategic planning and crisis management. This study develops a method to map abandoned cropland accurately, crucial for maintaining the food supply chain and ecological balance. Utilizing Sentinel-1/2 satellite data, we employed multi-feature stacking and machine learning to create the ARCC10-IM (Abandoned and Reclaimed Cropland Classification at 10-meter resolution in Inner Mongolia) dataset, which tracks annual cropland activity.

Uniform phosphazene containing porous organic polymer microspheres for highly efficient and selective silver recovery.

The efficient extraction of silver ions (Ag) from Ag-contaminated wastewater is crucial for resource recovery and environmental protection. However, the synthesis of adsorbents with high adsorption capacity and superior selectivity for Ag is a significant challenge. Herein, a series of phosphazene-based porous organic polymers (POPs) microspheres with exceptional selectivity and adsorption capacity for Ag were rationally designed using phosphazene and aromatic amines.

Pregnancy is associated with the prognosis of ovarian cancer patients with abdominal metastasis.

This study aims to explore a new approach to reduce the recurrence risk and improve the prognosis of ovarian cancer (OC) patients with abdominal metastasis by analyzing the clinical characteristics and prognostic factors. A total of 292 OC patients with abdominal metastasis, treated at Henan Provincial People's Hospital between 2021 and 2023 were included in this retrospective study. Follow-up was conducted for one year to observe the recurrence, with 285 patients completing the observation.

Comparative Effects of Bacillus strains applied Via Seed Biopriming and Soil Drenching Applications on the Morpho-Physiological and Transcriptional Aspects of Cotton.

Biofertilizers are considered as a sustainable solution for promoting the growth and productivity of crops while reducing the dependence on chemical fertilizers. There is a growing need for the sustainable agricultural solutions to lessen the reliance on chemical fertilizers; thus, evaluating Bacillus strains as biofertilizers for cotton growth promotion can support eco-friendly and economically viable crop production. Therefore, the growth promoting potential of endophytic Bacillus altitudinis strain TM22 and B.

Clinical and genetic analysis of epilepsy with myoclonic-atonic seizures caused by SLC6A1 gene variant.

Objective: This research intends to examine the clinical characteristics and genetic diversity of a child experiencing epilepsy with myoclonic-atonic seizures (EMAS) attributed to a variant in the SLC6A1 gene.

Methods: A male child diagnosed with EMAS underwent clinical and electroencephalographic evaluation. Peripheral blood samples were collected for DNA extraction and subsequent whole-exon gene sequencing.

Herbicide prometryn aggravates the detrimental effects of heat stress on the potential for mutualism of Symbiodiniaceae.

Ocean warming threatens the health of corals globally, and superimposed coastal environmental pollution can result in severe and irreversible coral bleaching. However, the responses of the coral symbiont Symbiodiniaceae to multiple stresses remain largely unknown. This study investigated the response of the coral symbiotic algae Cladocopium sp.

Boosting the oxygen reduction activity on metal surfaces by fine-tuning interfacial water with midinfrared stimulation.

Heterogeneous catalysis at the metal surface generally involves the transport of molecules through the interfacial water layer to access the surface, which is a rate-determining step at the nanoscale. In this study, taking the oxygen reduction reaction on a metal electrode in aqueous solution as an example, using accurate molecular dynamic simulations, we propose a novel long-range regulation strategy in which midinfrared stimulation (MIRS) with a frequency of approximately 1,000 cm is applied to nonthermally induce the structural transition of interfacial water from an ordered to disordered state, facilitating the access of oxygen molecules to metal surfaces at room temperature and increasing the oxygen reduction activity 50-fold. Impressively, the theoretical prediction is confirmed by the experimental observation of a significant discharge voltage increase in zinc-air batteries under MIRS.

20-Deoxyingenol ester and ether derivatives: Synthesis, properties and cytotoxicity.

The C-3 and C-5 substituted 20-deoxyingenol monoesters are important active components in Euphorbiaceae plants. Nonetheless, their similar physical properties make them difficult to distinguish. The present study developed fast and efficient rules for identifying the esterification sites of 20-deoxyingenol based on a series of chemical syntheses of monoesters and literature research, utilizing NMR spectroscopy, optical rotation analysis, and chromatographic retention behavior.

Autonomous Anticoagulation on a Biomimetic Al-Based Hierarchical Surface.

Studies targeting the blood repellency and autonomous anticoagulation of superhydrophobic (SH) surfaces are potentially valuable for their application in blood contact. The anticoagulation abilities and potential mechanisms of different SH surfaces urgently need to be revealed. In this study, a range of microprotrusion arrays on Al substrates with varying spacings via laser ablation through the utilization of organic adsorption and siloxane coupling reactions were fabricated.

Thymol as a Novel Plant-Derived Antibacterial Agent for Suppressing Xanthomonas citri pv. malvacearum in Cotton.

Xanthomonas citri pv. malvacearum (Xcm) associated with bacterial blight disease is a significant and widespread pathogen affecting cotton worldwide. The excessive use of harmful chemicals to control plant pathogens has exerted a negative impact on environmental safety.

Modified chevron osteotomy for the treatment of hallux valgus with unison bioabsorbable screws: Biomechanical research and clinical applications.

Researchers have modified PLA materials to enhance their mechanical properties and meet the clinical requirements. However, the strength and stiffness of PLA are still significantly lower than those of metals. Building on the established chevron clinical procedure and considering the mechanical characteristics of PLA screws, we devised a modified chevron osteotomy (MCO) based on a load-reducing structure with the aim of reducing the load on the screws.

Rapid screening of acetylcholinesterase inhibitors in Qi-Fu-Yin using magnetic metal-organic frameworks immobilized with acetylcholinesterase.

Current immobilization approaches for ligand fishing often experience challenges such as limited protein loading capacity and difficulties in the recycling process. To overcome these challenges, we synthesized a magnetic metal-organic frameworks (MMOFs) composite, which can be rapidly separated and has a large specific surface area, and employed it to immobilize acetylcholinesterase (AChE). The synthesized MMOFs@AChE composite exhibited a high immobilization yield (129.

Water-mediated cytosine self-assembly in infrared perspective.

Self-assembly plays a crucial role in the formation and allosteric processes of many biomolecules, water molecules can affect these processes. Cytosine (Cyt) has excellent self-assembly ability, forming a flat and ordered structure through hydrogen bonds (HBs) in the presence of water molecules. However, the vibration dynamics and interaction mechanism of water induced Cyt self-assembly are still unclear.

Associations Between Albumin/Neutrophil-to-Lymphocyte Ratio Score and New-Onset Atrial Fibrillation in Patients with Acute Myocardial Infarction Undergoing PCI.

Background: Inflammation was associated with the increased risk of atrial fibrillation (AF). As a novel inflammatory indicator, albumin/neutrophil-to-lymphocyte ratio score (ANS) has been demonstrated to associate with coronary artery disease. However, the relationship between ANS and new onset atrial fibrillation (NOAF) in patients with acute myocardial infarction (AMI) underwent PCI was not determined.

Diagnostic value of the MZXBTCH scoring system for acute complex appendicitis.

The objective of this study was to develop a novel scoring model, assess its diagnostic value for complex appendicitis, and compare it with existing scoring systems. A total of 1,241 patients with acute appendicitis were included, comprising 868 patients in the modeling group (mean age, 35.6 ± 14.

Ginsenosides, salidroside, and syringin complex exhibits anti-fatigue in exhaustive exercise rats.

Excessive exercise can lead to fatigue, consequently affect exercise performance, and further have an adverse impact to human health. The synergistic effects of ginsenosides, salidroside, and syringin on improving exercise performance remain unknown. Hence, the effects of Chinese herb powder (CHP) which consisted of bioactive compounds such as ginsenosides (Rg1, Re, and Rb1), salidroside, and syringin on exercise performance, energy metabolism, tissue damage, antioxidant activity, and inflammatory cytokine were investigated in exhaustive exercise rats.

Chameleon-inspired molecular imprinted polymer with bicolored states for visual and stable detection of diethylstilbestrol in water and food samples.

A novel biomimetic molecular imprinted polymer chip with fluorescence (FL) and structural (STR) states, inspired by color patterns of chameleon skin, is fabricated for detecting diethylstilbestrol (DES). The chip features a regularly structured, non-closed-packed (NCP) colloidal photonic crystal (CPC) lattice made monodisperse MIP spheres containing fluorescence poly ionic liquid (FPIL) pigments. The FL color originates from FPIL pigments and is further enhanced by the Purcell effect, while the STR color results from the periodic arrangement of the NCP CPC structure.