Identification of oxidative stress-related biomarkers in uterine leiomyoma: a transcriptome-combined Mendelian randomization analysis.

Background: Oxidative stress has been implicated in the pathogenesis of uterine leiomyoma (ULM) with an increasing incidence. This study aimed to identify potential oxidative stress-related biomarkers in ULM using transcriptome data integrated with Mendelian randomization (MR) analysis.

Methods: Data from GSE64763 and GSE31699 in the Gene Expression Omnibus (GEO) were included in the analysis.

Metal-phenolic network as precursor complex coating for forward osmosis membrane with enhanced antifouling property.

In this study, a multi-functional layer was developed based on the commercially available cellulose triacetate (CTA) forward osmosis (FO) membrane to improve its antifouling property. Tannic acid/ferric ion (TA/Fe) complexes were firstly coated as a precursor layer on the membrane surface via self-assembly. Afterwards, the tannic acid/diethylenetriamine (TA/DETA) hydrophilic functional layer was further coated, following Ag/polyvinylpyrrolidone (PVP) anti-bacterial layer was formed through the reducibility of TA to obtain TA/Fe-TA/DETA-Ag/PVP-modified membrane.

The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury.

Hydrogen, which is a novel biomedical molecule, is currently the subject of extensive research involving animal experiments and in vitro cell experiments, and it is gradually being applied in clinical settings. Hydrogen has been proven to possess anti-inflammatory, selective antioxidant, and antiapoptotic effects, thus exhibiting considerable protective effects in various diseases. In recent years, several studies have provided preliminary evidence for the protective effects of hydrogen on spinal cord injury (SCI).

Treatment of landfill leachate by coagulation: A review.

Landfill leachate is a seriously polluted and hazardous liquid, which contains a high concentration of refractory organics, ammonia nitrogen, heavy metals, inorganic salts, and various suspended solids. The favorable disposal of landfill leachate has always been a hot and challenging issue in wastewater treatment. As one of the best available technologies for landfill leachate disposal, coagulation has been studied extensively.

Therapeutic Effects of Mechanical Stress-Induced C2C12-Derived Exosomes on Glucocorticoid-Induced Osteoporosis Through miR-92a-3p/PTEN/AKT Signaling Pathway.

Introduction: Osteoporosis is a common bone disease in which the bone loses density and strength and is prone to fracture. Bone marrow mesenchymal stem cells (BMSCs) are important in bone-related diseases. Exosomes, as mediators of cell communication, have potential in cell processes.

Polydopamine modified cerium-based MOFs/ chitosan aerogel beads for the efficient phosphate removal.

The metal organic frameworks (MOFs) are considered as the effective adsorbents for phosphate removal, while their ultrafine powders limit their practical application. In this study, we fabricate two chitosan (CS) gel beads added with different cerium-based MOFs and coated with PDA for phosphate adsorption. The MOFs doped in beads are CM1 and CM2, in which the Ce(III)/Ce(IV) ratio is 0.

Insight into the electron transfer regime of periodate activation on MnO: The critical role of surface Mn(IV).

At present, the potential mechanism of manganese oxide (MnO) activation of PI and the key active sites of PI activation are still unclear and controversial. To this end, three different crystal forms of MnO were prepared in this study and used to activate PI to degrade pollutants. The results showed that different crystal types of MnO showed different catalytic abilities, and the order was γ-MnO > α-MnO > β-MnO.

Significance of Exhaled Nitric Oxide and Carbon Monoxide in Auxiliary Diagnosis and Evaluation of Allergic Rhinitis.

Objective: The concentration of exhaled NO and CO is considered as a candidate marker of respiratory inflammatory disease. This report discusses the exhaled NO and CO in the auxiliary diagnosis and evaluation of allergic rhinitis (AR).

Methods: 60 AR patients from October 2017 to March 2019, compared with 30 healthy controls.

Differential susceptibility to SARS-CoV-2 in the normal nasal mucosa and in chronic sinusitis.

Human nasal mucosa is susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and serves as a reservoir for viral replication before spreading to other organs (e.g. the lung and brain) and transmission to other individuals.

[Adsorption Properties and Host-guest Effects of Porous Cyclodextrin Polymers for Dye Molecules in Water].

Cyclodextrin can form host-guest inclusion complexes with a variety of organic pollutants and has unique advantages in removing complex dye molecules from water. In this study, a porous cyclodextrin polymer (P-CDP) was prepared using a rigid crosslinking agent, and the structure of the P-CDP was characterized by FT-IR, XPS, SEM, BET, and other technologies. The P-CDP was studied using isothermal adsorption and kinetic adsorption experiments.

Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) accelerates osteoclast formation by regulating signal transducer and activator of transcription 3 (STAT3) signalling.

Osteoclasts (OCs), the main cause of bone resorption irregularities, may ultimately cause various bone diseases, including osteoarthritis. The objective of this study was to investigate the effect of interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) on OC formation induced by receptor activator of nuclear factor κB (NF-κB) ligand (RANKL) and to further explore its underlying mechanism. IFIT1 expression in Raw264.

Visible-light induced activation of persulfate by self-assembled EHPDI/TiO photocatalyst toward efficient degradation of carbamazepine.

Removal of pharmaceutical and personal care products from wastewater is very important in water treatment process. Combining photocatalysis with persulfate (PS) could be a good solvent for this problem. Novel perylene diimide derivative (EHPDI) was designed and synthesized.

Application of magnetic fields to wastewater treatment and its mechanisms: A review.

Magnetic field (MF) has been applied widely and successfully as an efficient, low-cost and easy-to-use technique to enhance wastewater treatment (WWT) performance. Although the effects of MF on WWT were revealed and summarized by some works, they are still mysterious and complex. This review summarizes the application of MF in magnetic adsorption-separation of heavy metals and dyes, treatment of domestic wastewater and photo-magnetic coupling technology.

Application of coagulation/flocculation in oily wastewater treatment: A review.

Volumes of oily wastewater are inevitably generated by every walk of life. The removal of oil particles from oil-contaminated wastewater which is characterized as huge amounts, intricate composition, and great threats to human health and the ecological environment is a research hotspot in water treatment fields. Due to high treatment costs and undesirable treatment efficiencies, oily wastewater treatment remains a topical and urgent issue.

Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/BiWO) composite.

An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/BiWO), was successfully synthesized by the simple hydrothermal method. Moreover, the MCTS-Ag/BiWO demonstrated excellent adsorption/photocatalytic removal of Cu(II) in aqueous solution. Adsorption played a leading role in the synergistic reaction.

Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers.

Ferroptosis is a novel form of non-apoptotic regulated cell death (RCD), with distinct characteristics and functions in physical conditions and multiple diseases such as cancers. Unlike apoptosis and autophagy, this new RCD is an iron-dependent cell death with features of lethal accumulation of reactive oxygen species (ROS) and over production of lipid peroxidation. Excessive iron from aberrant iron metabolisms or the maladjustment of the two main redox systems thiols and lipid peroxidation role as the major causes of ROS generation, and the redox-acrive ferrous (intracellular labile iron) is a crucial factor for the lipid peroxidation.

What is the efficacy of gentamicin on the incidence of vertigo attacks and hearing in patients with Meniere's disease compared with steroids? A meta-analysis.

Objective: To compare the efficacy of gentamicin and steroids in patients with Meniere's disease (MD).

Methods: The study protocol was structured in accordance with the Population, Intervention, Comparison and Outcome (PICO) framework. We used "Endnote" (Thomson ResearchSoft; Stanford, Connecticut, the United States) to retrieve database documents.

Novel cationic polymer modified magnetic chitosan beads for efficient adsorption of heavy metals and dyes over a wide pH range.

Wastewater containing highly toxic and non-biodegradable heavy metals and organic dyes poses a serious threat to ecological environment and human health. Adsorption has been regarded as a promising technology to purify this kind of wastewater. Therefore, it is of great importance to develop efficient adsorbents.

Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury.

Purpose: Spinal cord injury (SCI) is a relatively common, devastating traumatic condition resulting in permanent disability. In this study, the use of exosomes derived from bone mesenchymal stem cells (BMSCs-Exo) as a cell-free therapy for the treatment of SCI in rats was investigated to gain insights into their mechanisms of action.

Methods: Rats were randomly divided into three groups, Sham (treated with PBS), SCI (SCI injury + PBS) and SCI + Exo (SCI injury + BMSCs-Exo).

Better understanding the polymerization kinetics of ultrasonic-template method and new insight on sludge floc characteristics research.

As one of the core technologies employed in the field of sludge conditioning, flocculation has the ability to improve the sludge dewatering performance and reduce its volume and amount, which can accordingly result in lower costs in sludge transportation as well as subsequent disposal. Therefore, the development of new and high-efficiency flocculants is a hot topic in this field. The template copolymer (TPAD) of acryloyloxyethyl trimethyl ammonium chloride (DAC) and acrylamide (AM) was successfully synthesized through ultrasonic-template copolymerization using sodium-polyacrylate (NaPAA) as a template.

Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axis.

Spinal cord injury (SCI) represents a relatively common type of motor system trauma. While the SCI patient will experience varying degrees of paraplegia and quadriplegia, which severely affects their quality of life, a heavy burden is also placed on the family and society as a whole. The exact pathogenic mechanisms underlying this condition remain unknown and no specific treatments are currently available.