Metal covalent organic frameworks-based laccase-like nanozyme for oxidative degradation and identification of phenolic pollutants.

Phenolic compounds are a kind of persistent organic pollutants (POPs), which are always a threat to human and environment due to their strong toxicity and low biodegradability. Therefore, developing a reliable method to simultaneously detect phenolic pollutants is of great importance to environmental safety and human health. Herein, we combined the advantages of metal organic frameworks (MOFs) and covalent organic frameworks (COFs) to prepare two cyclic trinuclear unit-based metal covalent organic framework (MCOFs, denoted as Cu-TDH COF and Cu-BDU COF) with large specific surface area, good stability and excellent laccase-like activity.

PLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy.

Idiopathic pulmonary fibrosis (IPF) is an irreversible lung condition that progresses over time, which ultimately results in respiratory failure and mortality. In this study, we found that PLAC8 was downregulated in the lungs of IPF patients based on GEO data, in bleomycin (BLM)-induced lungs of mice, and in primary murine alveolar epithelial type II (pmATII) cells and human lung epithelial cell A549 cells. Overexpression of PLAC8 facilitated autophagy and inhibited apoptosis of pmATII cells and A549 cells in vitro.

Research on a Low-Cost, Low-Waste Method for Surface Flatness Improvement of WAAM Components Based on Tungsten Inert Gas Arc Remelting (TIGAR).

Wire-arc additive manufacturing (WAAM) has fully empowered the design and manufacturing of metals with its unparalleled efficiency and flexibility. However, the process has relatively poor shape control capabilities, often requiring machining post-processing. This study explores a tungsten inert gas arc remelting (TIGAR) process to improve the surface flatness of WAAM components at a low cost and significantly reduce machining waste (up to 76%), which is crucial for the sustainable development of the process.

RNA mA involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells.

Cadmium has been identified as an environmental pollutant and a carcinogen. N-methyladenosine (mA) plays a crucial role in the development of lung tumors, but the mechanisms remain incompletely clarified. In present study, our data demonstrated that prolonged treatment of 1 μmol/L CdSO for 40 passages in bronchial epithelial cells (Beas-2B cells) resulted in the development of a malignant phenotype, which manifested as boosted proliferation, migration and invasion capacity as well as apoptosis reduction.

Same-Slide Spatial Multi-Omics Integration Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment.

The advent of spatial transcriptomics and spatial proteomics have enabled profound insights into tissue organization to provide systems-level understanding of diseases. Both technologies currently remain largely independent, and emerging same slide spatial multi-omics approaches are generally limited in plex, spatial resolution, and analytical approaches. We introduce IN-situ DEtailed Phenotyping To High-resolution transcriptomics (IN-DEPTH), a streamlined and resource-effective approach compatible with various spatial platforms.

A deformable SIS/HA composite hydrogel coaxial scaffold promotes alveolar bone regeneration after tooth extraction.

After tooth extraction, alveolar bone absorbs unevenly, leading to soft tissue collapse, which hinders full regeneration. Bone loss makes it harder to do dental implants and repairs. Inspired by the biological architecture of bone, a deformable SIS/HA (Small intestinal submucosa/Hydroxyapatite) composite hydrogel coaxial scaffold was designed to maintain bone volume in the socket.

Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization.

The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNALP) is essential for the immortalization of naive B lymphocytes (NBLs). However, the mechanisms remain elusive. To understand EBNALP's role in B-cell transformation, we compare NBLs infected with wild-type EBV and an EBNALP-null mutant EBV using multi-omics techniques.

LncRNA TMC3-AS1 silence alleviates lipopolysaccharide-induced acute kidney injury by suppressing Wnt5a-mediated autophagy and pyroptosis pathway.

Long non-coding RNA TMC3-AS1 is identified to be upregulated by lipopolysaccharide (LPS) in inflammatory disease, but its role in acute kidney injury (AKI) is almost unknown. The study investigated the involvement of TMC3-AS1 in LPS-induced AKI and its downstream molecular regulatory mechanism. Our data suggested that knocking down TMC3-AS1 significantly reduced renal dysfunction, tissue inflammation and tissue damage in LPS-induced mice, and promoted cell viability, inhibited inflammation, apoptosis and necrosis in LPS-stimulated human renal tubular epithelial cells HK2.

The impact of metabolic component count on IgA nephropathy prognosis.

Metabolic syndrome, a cluster of conditions including obesity, hyperglycemia, hypertension, and dyslipidemia, is increasingly recognized for its association with kidney disease. However, the impact of metabolic syndrome on the long-term prognosis of IgA nephropathy(IgAN) remains understudied. From August 2009 to December 2018, we conducted a retrospective cohort study at the Department of Nephrology, General Hospital of Ningxia Medical University, involving 698 patients with primary IgAN identified by the initial renal biopsy.

Integrating tumour and lymph node radiomics features for predicting disease-free survival in locally advanced esophageal squamous cell cancer after neoadjuvant chemotherapy and complete resection.

Purpose: To investigate the utility of combined tumour and lymph node (LN) radiomics features in predicting disease-free survival (DFS) among patients with locally advanced esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemotherapy and resection.

Methods: We retrospectively enrolled 176 ESCC patients from January 2013 to December 2016. Tumour and targeted LN segmentation were performed on venous phase CT images.

Transdermal delivery of natural products against atopic dermatitis.

Atopic dermatitis (AD) is a chronic inflammatory skin condition. Natural products have gained traction in AD treatment due to their accessibility, low toxicity, and favorable pharmacological properties. However, their application is primarily constrained by poor solubility, instability, and limited permeability.

Disruption of RNA-binding proteins in neurological disorders.

RNA-binding proteins (RBPs) are multifunctional proteins essential for the regulation of RNA processing and metabolism, contributing to the maintenance of cell homeostasis by modulating the expression of target genes. Many RBPs have been associated with neuron-specific processes vital for neuronal development and survival. RBP dysfunction may result in aberrations in RNA processing, which subsequently initiate a cascade of effects.

A global product of 150-m urban building height based on spaceborne lidar.

Urban building height, as a fundamental 3D urban structural feature, has far-reaching applications. However, creating readily available datasets of recent urban building heights with fine spatial resolutions and global coverage remains a challenging task. Here, we provide a 150-m global urban building heights dataset around 2020 by combining the spaceborne lidar (Global Ecosystem Dynamics Investigation, GEDI), multi-sourced data (Landsat-8, Sentinel-2, and Sentinel-1), and topographic data.

Research Progress in Shape-Control Methods for Wire-Arc-Directed Energy Deposition.

Wire-arc-directed energy deposition (WA-DED) stands out as a highly efficient and adaptable technology for near-net-shaped metal manufacturing, with promising application prospects. However, the shape control capability of this technology is relatively underdeveloped, necessitating further refinement. This review summarizes the latest advancements in the shape control of WA-DED technology, covering four pivotal areas: the regulation of various process parameters, optimization of the deposition paths, control through auxiliary energy and mechanical fields, and synergy between additive and subtractive manufacturing approaches.

The impact of sidewall copper grain condition on thermo-mechanical behaviors of TSVs during the annealing process.

With the drastic reduction of the TSV diameter leading to a critical dimension comparable to the Cu-filled grain size, the grain condition strongly influences the thermo-mechanical behavior of the TSV. In this work, the TSV-Cu cross-section with different grain sizes is characterized by EBSD, confirming that the sidewall grain size (0.638-1.

Short chain fatty acids mediates complement C1q pathway alleviation of perioperative neurocognitive disorders.

Perioperative neurocognitive disorders (PND) is one of the most common postoperative complications, which can lead to a harmful impact on self-dependence, longer hospital stays, increased medical costs, morbidity, and mortality amongst older adults. Microglia can modulate synapse elimination involved in the complement component protein 1q (C1q) pathway to induce cognitive dysfunction, which is significantly improved by short chain fatty acids (SCFAs) treatment. Here we investigate the effects of SCFAs treatment on PND via mediating C1q complement pathway.

A Constant Filgotinib Delivery Adhesive Platform Based on Polyethylene Glycol (PEG) Hydrogel for Accelerating Wound Healing via Restoring Macrophage Mitochondrial Homeostasis.

Skin wound healing is often hindered by disrupted mitochondrial homeostasis and imbalanced macrophage glucose metabolism, posing a critical challenge to improve patient outcomes. Developing new wound healing dressings capable of effectively regulating macrophage immune-metabolic functions remains a pressing issue. Herein, a highly adhesive polyethylene glycol (PEG) hydrogel loaded with the Janus kinase 1 (JAK1) inhibitor Filgotinib (Fil@GEL) is prepared to modulate macrophage metabolic reprogramming and restore normal mitochondrial function.

Chitosan-BODIPY fluorescent composite materials for photodynamical antibacterial and therapy.

Chitosan-based fluorescent copolymers containing borodipyrromethene (BODIPY) were synthesized and investigated. In this work, fluorescent compound (BOD-4) containing -C ≡ CH was synthesized firstly. Subsequently, chitosan (CS)-based polymer CS-I was obtained through the -NH/-C ≡ C click reaction between BOD-4 and CS.

Rational Design of Porous YO-MnO/Carbon Heterostructures with Abundant Oxygen Vacancies for High-Efficiency and Ultrastable Zinc-Ion Storage.

Manganese oxides have been considered as the most competitive cathode materials for aqueous zinc-ion batteries (ZIBs) on account of their inherent safety, high operating voltage, environmental friendliness, and cost-effectiveness. Unfortunately, the manganese dissolution, inherently poor electronic conductivity, and the sluggish reaction kinetics of commercial manganese-based oxides severely hinder their practical applications. To address the above issues, we creatively developed hierarchical porous YO-MnO/C nanorods (named O-YMO/C) with unique heterostructures and abundant oxygen vacancies via a facile MOF-assisted synthetic process and employed as the advanced cathode.

Optimizing Electrocatalysis and Domain Effects of Graphene on LiS Cathodes for High-Efficient-Stable Li─S Batteries.

Reducing the initial activation barrier of LiS is crucial for enhancing the coulomb efficiency and cycle life of Li─S batteries. Herein two LiS-graphene cathode architectures are constructed and investigated the electrocatalytic and domain effects of two graphene on LiS. Systematic studies reveal an unprecedented relevancy between LiS activation and graphene electrocatalysis, as well as an intrinsic relationship between LiS stability and the graphene domain.

Gas migration control in goaf with double roof cutting and retaining roadway.

The behavior of gas migration in goaf under double roof cutting conditions directly influences the effectiveness of gas control measures. This study employs a combination of numerical simulation and field verification to investigate the patterns of gas migration and accumulation in goaf and to develop coordinated gas control methods under the conditions of double roof cutting and retained roadway. The results indicate that with double roof cutting, goaf permeability generally increases from the interior towards the exterior, with significantly higher porosity in the separation range compared to other areas.

Innovative engineering of superoxide dismutase for enhanced cardioprotective biocatalysis in myocardial ischemia-reperfusion injury.

The present research compares the stability, catalytic activity, and cardioprotective benefits of the designed superoxide dismutase (SOD) variation SOD-M3 to those of the naturally occurring enzyme, along with additional alternatives. SOD-M3 exhibited a 51.5 % increase in expression yield, reaching 50 mg/L, compared to the wild-type's 33 mg/L.

Effect of salt and alkali on the viscoelastic behavior of noodle dough sheet with different wheat starch granule sizes.

The underlying mechanisms of salt and alkali on the viscoelastic behaviors of noodle dough sheets with varied B/A-type starch ratios were investigated from water state, protein polymerization and conformation, and microstructure. The viscoelastic behaviors of dough sheets increased with increasing B/A-type starch ratio, regardless of the presence of salt and alkali, indicating the addition of salt and alkali did not change the effect law of starch granule size on dough viscoelasticity. The viscoelastic moduli of dough decreased in the presence of salt and alkali, and the effect was more obvious as the ratio of B/A-type starch decreased, which was mainly determined by the interactions of protein-protein, protein-starch, and starch-starch in dough systems.

Association Between Weight-Adjusted Waist Index and Emphysema in Adults in the United States: A Cross-Sectional Study Involving 44,949 Participants.

: The relationship between obesity and respiratory diseases has been widely explored. In this context, the Weight-Adjusted Waist Index (WWI) has emerged as a novel metric for assessing visceral fat. This study aims to evaluate the association between WWI and the risk of emphysema in the U.