Urinary profiles of bisphenol S derivatives and their exposure pathway analysis in maternal and infant populations of Beijing.

Bisphenol S (BPS) derivatives have potential reproductive developmental toxicity and have been found in the environment and in breast milk. The level of infant exposure and the source are currently unknown. In this study, we investigated BPS and six derivatives (together referred to as BPs) in urine samples from mothers and infants, indoor dust, breast milk and infant formula in Beijing, China.

Red fermented rice elution fractions inhibits cancer cell proliferation by regulating the FGFR1/PI3K/AKT signaling pathway.

This study aims to elucidate the potential targets and molecular mechanisms underlying the anticancer effects of Red fermented rice extract using molecular simulation techniques. The inhibitory effects of different elution fractions of Red fermented rice extract on A549 and MCF-7 cell proliferation were evaluated through CCK-8 assays. Liquid chromatography-mass spectrometry (LC-MS) was employed to elucidate the structural information of active components, while molecular simulation techniques aided in identifying target proteins based on small molecule structures.

Separation and identification of enzyme inhibition peptides from dark tea protein.

Two key enzymes like α-glucosidase and dipeptidyl peptidase-4 (DPP4) play an important role in the development of Type 2 diabetes (T2D), and inhibiting them is a common treatment strategy for T2D. In this study, an ultrafiltration- centrifugation approach was developed to isolate peptides from dark protein extract. Consequently, 6 peptides TAELLPR, CGKKFVR, AVPANLVDLNVPALLK, VVDLVFFAAAK, MSLYPR and QGQELLPSDFK were identified.