Differential Diagnosis of Urinary Cancers by Surface-Enhanced Raman Spectroscopy and Machine Learning.

Bladder, kidney, and prostate cancers are prevalent urinary cancers, and developing efficient detection methods is of significance for the early diagnosis of them. However, noninvasive and sensitive detection of urinary cancers still challenges traditional techniques. In this study, we developed a SERS-based method to analyze serum samples from patients with urinary cancers.

Correlation of lipid hydrolysis, oxidation, and molecular transformation with volatile compound revolution in pork during postmortem wet-aging process.

Lipid hydrolysis and oxidation properties, lipid metabolites, and volatile flavors were investigated to elucidate the wet-aging process (1 h to 10 d) on lipid molecule transformation and volatile flavor evolution in pork. Phospholipase A (PLA) activity increased at 12 h, with lipoxygenase (LOX) increasing from 1 h to 7 d (P < 0.05).

Step Cyclization to Give Part Belt Oxygen-Functionalized Pillar[6,10]arenes.

Part belt oxygen-functionalized pillar[6,10]arenes are synthesized by step cyclization. An oxygen-substituted tetramer and hexamer have been prepared to construct the O3 pillar[6]arene via a hexamer cyclization reaction and the O6 pillar[10]arene through a [4 + 1+4 + 1] cyclization reaction. X-ray crystallographic studies reveal that both macrocycles have a large cavity and indicate that the part belt oxygen-functionalized pillar[6,10]arenes have both similar cyclic structures and certain differences in configuration compared to pillararene.

Standard: Human gastric cancer organoids.

Gastric cancer is one of the most common malignancies with poor prognosis. The use of organoids to simulate gastric cancer has rapidly developed over the past several years. Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics, offering new opportunities for both basic and applied research.

Supercritical CO coupled with water washing to enhance the removal of chlorine in MSWI fly ash together with its carbon sequestration function.

The high chlorine content in municipal solid waste incineration (MSWI) fly ash is a key factor restricting its treatment and disposal. In this study, a new treatment method was proposed to enhance the deep dechlorination of fly ash by coupling supercritical CO (SC) treatment with water washing. Simultaneously the alkaline compounds in fly ash can fix CO and achieve CO credits.

Discovery of Novel 4,5,6,7-Tetrahydro-7-pyrazolo[3,4-]pyridin-7-one Derivatives as Orally Efficacious ATX Allosteric Inhibitors for the Treatment of Pulmonary Fibrosis.

Pulmonary fibrosis (PF) is a progressive, fatal lung disease lacking effective treatments. Autotaxin (ATX) plays a crucial role in exacerbating inflammation and fibrosis, making it a promising target for fibrosis therapies. Herein, starting from PAT-409 (Cudetaxestat), a series of novel ATX inhibitors bearing 1-indole-3-carboxamide, 4,5,6,7-tetrahydro-7-pyrazolo[3,4-]pyridin-7-one, or 4,5,6,7-tetrahydro-1-pyrazolo[4,3-]pyridine cores were designed based on the structure of ATX hydrophobic tunnel.

An aptamer sensor based on AgNPs@MOF for surface-enhanced Raman spectroscopy detection of sulfadimethoxine in food.

A highly sensitive aptamer sensor (aptasensor) is proposed based on metal-organic frameworks-silver nanoparticles (AgNPs@MOF) to detect sulfadimethoxine (SDM) by surface-enhanced Raman spectroscopy (SERS). AgNPs@MOF with SERS activity was successfully fabricated by synthesizing AgNPs in situ on the surface of MIL-101(Fe), and SDM aptamer and Raman reporter 4-aminophenthiophenol (4-ATP) were selected as specific recognition elements and signal probes, respectively. When SDM was absent, the SDM aptamers were effectively adsorbed on the surface of AgNPs@MOF, thus keeping AgNPs@MOF in a dispersed state, resulting in a weakened SERS signal of 4-ATP.

Surface-enhanced Raman spectroscopy: a half-century historical perspective.

Surface-enhanced Raman spectroscopy (SERS) has evolved significantly over fifty years into a powerful analytical technique. This review aims to achieve five main goals. (1) Providing a comprehensive history of SERS's discovery, its experimental and theoretical foundations, its connections to advances in nanoscience and plasmonics, and highlighting collective contributions of key pioneers.

Implication of serum soluble IL-2 receptor α in type 2 diabetes mellitus.

Objectives: The aim of this study was to determine the association of serum soluble IL-2 receptor α (sIL-2RA) with T2DM-related characteristics and complications.

Methods: Serum sIL-2RA levels were determined in 156 T2DM patients, and the association with T2DM-related characteristics and complications was evaluated.

Results: Serum sIL-2RA levels were significantly increased in T2DM patients with diabetic kidney disease (DKD) (median, IQR, 1434.

Development of differential diagnostic models for distinguishing between limb-girdle muscular dystrophy and idiopathic inflammatory myopathy.

Objective: Limb-girdle muscular dystrophy (LGMD) is usually confused with idiopathic inflammatory myopathy (IIM) in clinical practice. Our study aimed to establish convenient and reliable diagnostic models for distinguishing between LGMD and IIM.

Methods: A total of 71 IIM patients, 24 LGMDR2 patients and 22 LGMDR1 patients diagnosed at our neuromuscular center were enrolled.

Exogenous organic acids promoted phytoremediation by Hydrangea macrophylla in cadmium‑contaminated soil.

Cadmium (Cd) contaminants with high toxicity and mobility seriously threatens the ecological environment and human safety. Hydrangea macrophylla is a potential plant for Cd-contaminated soil remediation. Exogenous organic acids have been proven to effectively enhance the phytoremediation of soil contaminated with Cd.

Surface double defects-dominated TiO with high liquid phase stability for smart SERS sensing of dye additives in foods.

Surface defect engineering is an effective strategy to regulate the physical and chemical properties of semiconductors for a wide range of applications. Herein, a surface-highly-reduced anatase TiO (R-TiO) with double defects (surface oxygen vacancy defect and Ti energy level defect) was developed as a plasmon-free surface-enhanced Raman scattering (SERS) substrate for ultrasensitive detection of food additives. Abundant surface oxygen vacancies enable R-TiO to exist stably in liquid phase, which realizes a smart SERS detection for dye target molecules due to evading fluorescent interference from analytes, while SERS enhancement of analytes cannot be observed on the solid phase substrate at all.

(001) facet-supported TiO facet heterojunction with abundant active sites and high-efficiency carrier separation for ultrasensitive SERS detection of antibiotic residues in foods.

Background: Antibiotic residues in animal-derived foods are seriously threatening human health and have attracted growing public attention. It is very important and valuable to carry out a rapid ultrasensitive detection of antibiotic residues, especially accurate identification based on molecular fingerprints.

Results: Here, a (001) facet-supported TiO facet heterojunction with abundant active sites (SF-TiO) was developed as a surface-enhanced Raman scattering (SERS) substrate for ultrasensitive detection of antibiotic residues in milk and honey foods.

Irregular pulsation on 4D-CTA and quantitative wall enhancement on VW-MRI are associated with symptoms of unruptured intracranial aneurysms.

Background: Unruptured intracranial aneurysms (IAs) that become symptomatic have been associated with instability.

Objective: To investigate the relationship between irregular pulsation on four-dimensional CT angiography (4D-CTA) and aneurysm wall enhancement (AWE) on vessel wall MRI (VW-MRI), and to evaluate their ability to identify symptomatic IAs.

Methods: This retrospective study included consecutive patients with IAs who underwent 4D-CTA and VW-MRI between March 2018 and May 2023.

Knockdown of CENPF induces cell cycle arrest and inhibits epithelial‑mesenchymal transition progression in glioma.

Gliomas are among the most common malignant tumors of the central nervous system. Despite surgical resection followed by postoperative radiotherapy and chemotherapy, their prognosis remains unfavorable. The present study aimed to assess new mechanisms and explore promising prognostic biomarkers for patients with glioma using comprehensive bioinformatics analysis and and assays.

SERS-Based Aptamer Sensing Strategy for Diabetes Biomarker Detection.

Accurate detection of glucose and insulin is crucial for early diagnosis, classification, and timely prevention of diabetes. In this study, we present a novel surface-enhanced Raman scattering (SERS) aptasensor for glucose and insulin detection. The SERS aptasensor is composed of gold bipyramidal nanoparticles (Au BPs), SH-aptamer-methylene blue (MB), and thiolated polyethylene glycol (SH-PEG).

Dynamic microbial community and metabolic profiling in refrigerated beef: Insights from diverse packaging strategies.

Extending the shelf life of fresh beef is essential for meat industry. This study explored the microbial community succession, metabolic profile changes, and their interactions during refrigerated storage of beef under different packaging methods. The results showed that compared with air packaging (AP), vacuum packaging (CV) and vacuum skin packaging (VS) maintained higher microbial diversity over longer periods.

miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway.

Background: Preeclampsia (PE) is a severe pregnancy complication characterized by complex molecular interactions. Understanding these interactions is crucial for developing effective therapeutic strategies.

Methods: This study applies a pharmacometabolomics approach to explore the roles of miR-155 and PKG1 in PE, focusing on the regulatory influence of the NF-κB signaling pathway.