Publications by authors named "Zhao Bao-Lian"
Necroptosis Signaling Pathways in Stroke: From Mechanisms to Therapies.
Curr Neuropharmacol
November 2018
Article Synopsis
- Apoptosis, autophagy, and necrosis are the three main types of cell death, with necrosis recently recognized as a regulated process called necroptosis rather than just accidental death.
- Necroptosis is triggered by external factors and operates through a caspase-independent pathway, playing a significant role in conditions like neurological diseases and strokes.
- Research indicates that inhibiting necroptosis can be neuroprotective in stroke, making it a potential therapeutic target, and the review discusses recent findings and treatment strategies related to necroptosis in stroke.
Stroke is a cerebrovascular disease with high mortality and morbidity. Despite extensive research, there are only a very limited number of therapeutic approaches suitable for treatment of stroke patients as yet. Mounting evidence has demonstrated that such gases as oxygen, hydrogen and hydrogen sulfide are able to provide neuroprotection after stroke.
View Article and Find Full Text PDF