Metabolic engineering of Escherichia coli for high-level production of benzyl acetate from glucose.

Background: Benzyl acetate is an aromatic ester with a jasmine scent. It was discovered in plants and has broad applications in food, cosmetic, and pharmaceutical industries. Its current production predominantly relies on chemical synthesis.

The Discovery of Weddellamycin, a Tricyclic Polyene Macrolactam Antibiotic from an Antarctic Deep-Sea-Derived sp. DSS69, by Heterologous Expression.

Polyene macrolactams are a special group of natural products with great diversity, unique structural features, and a wide range of biological activities. Herein, a cryptic gene cluster for the biosynthesis of putative macrolactams was disclosed from a sponge-associated bacterium, sp. DSS69, by genome mining.

Metabolic Engineering of for High-Level Production of Salicin.

Salicin is a notable phenolic glycoside derived from plants including and genus and has multiple biological activities such as anti-inflammatory and antiarthritic, anticancer, and antiaging effects. In this work, we engineered production of salicin from cheap renewable carbon resources in () by extending the shikimate pathway. We first investigated enzymes synthesizing salicylate from chorismate.