Cyanogroup-Modified PEO-Based Electrolytes Achieve High Free Al Concentration and Improve the Transport Dynamics in Solid-State Aluminum-Ion Batteries.

Polymer-based solid electrolyte boasting ultra-high safety, energy density, mechanical strength and flexibility, attracting much attention in the field of battery applications. However, its widespread application is hindered by the low conductivity, insufficient aluminium salt dissociation, high crystallization degree, short service life, etc. To solve the above problems, a composite solid polymer electrolyte (SPE) design based on polyethylene oxide (PEO, Mw = 6 000 000) with AlCl·6HO as aluminum salt and butanedinitrile (SN) as plasticizer is proposed in this paper.

An π-conjugated organic cathode with multiple cyano-substituted for stable aqueous aluminum batteries.

Aqueous organic aluminum batteries (AOABs) are increasingly becoming a focal point for next-generation large-scale energy storage solutions due to their safety, reliability, and structural diversity. However, the development of organic molecules is hindered by their low electron affinity and slow molecular dynamics. To address these drawbacks, a high-electrophilicity organic molecule, DQP-6CN was synthesized.

In Situ Synthesis of MoO by Surface Oxidation of MoC (MXene) for Stable Near-Surface Reactions in Aqueous Aluminum-Ion Battery.

Molybdenum trioxide (MoO) is a promising positive electrode material for aqueous aluminum-ion batteries (AAIBs) due to its high theoretical capacity. However, MoO faces several challenges in an aqueous electrolyte, such as easy dissolution of reaction products, volume expansion, and low conductivity, which severely limit its application in aqueous batteries. In this work, we effectively increased the overall conductivity of the electrode by in situ growing MoO on the MoC MXene layer.

Eco-Friendly Cellulose-Supported Nickel Complex as an Efficient and Recyclable Heterogeneous Catalyst for Suzuki Cross-Coupling Reaction.

In this work, we applied commercially available 2-pyridinecarboxylic acid to modify cellulose by simple manipulations, and then anchored low-toxicity metal nickel onto the modified cellulose to prepare the heterogeneous catalyst (CL-AcPy-Ni). The obtained catalyst was characterized by FT-IR, TG-DSC, BET, XRD, SEM-EDS, ICP-OES, XPS, and GPC. The catalytic performance of CL-AcPy-Ni in the Suzuki cross-coupling reaction was investigated using 4-methyl iodobenzene and phenylboronic acid as the model substrates reacting in THF under 120 °C for 24 h.

The Effectiveness and Safety Analysis of Duloxetine in Treating Comorbid Depression in Parkinson's Disease: A Retrospective Study.

Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor symptoms, including depression, which significantly impacts the quality of life of affected individuals. This study aims to investigate the real-world effectiveness and safety of duloxetine in treating comorbid depression in patients with Parkinson's disease and to compare its outcomes with traditional treatment approaches.

Methods: This study included adult patients diagnosed with Parkinson's disease combined with depression from December 2020 to December 2023.

Hollow tubular sea-urchin structure with high catalytic activity of NiCoSe@CS cathodes for high-performance Al/S batteries.

The shuttle effect of aluminum polysulfides (AlPSs) have been a source of concern for studying Al/S batteries. Due to the weak adsorption of CS composites, research on cathode materials for Al/S batteries has been delayed. As it is generally known that AlS decomposition demands a large Gibbs free energy, this work has tried to reduce the AlS decomposition potential energy.

Prospective study of Tc-3PRGD SPECT/CT diagnosing metastatic lymph nodes in esophageal squamous cell carcinoma.

Background: Lymph node (LN) metastasis is a significant prognostic factor for esophageal squamous cell carcinoma (ESCC), and there are no satisfactory methods for accurately predicting metastatic LNs. The present study aimed to assess the efficacy of Tc-3PRGD single-photon emission computed tomography (SPECT)/computed tomography (CT) for diagnosing metastatic LNs in ESCC.

Methods: A total of 15 enrolled patients with ESCC underwent Tc-3PRGD SPECT/CT and 18F-fluorodeoxyglucose positron emission tomography-computed tomography (F-FDG PET/CT) examinations preoperatively.

MoO nanobelts cathode promotes Al insertion in aqueous aluminum-ion batteries.

Aqueous aluminium ion batteries (AAIBs) have attracted much attention due to their high theoretical capacity, safety, and environmental friendliness. However, the Research and Development (R&D) of cathode materials has limited its development and application. MoO has been proven to be a reliable and stable cathode material, nevertheless, it faces the dilemma of poor cycling performance and low specific capacity in AAIBs due to the irreversible phase transition in its structure.

Construction of VO@MXene Cathodes toward a High Specific Capacity Aqueous Aluminum-Ion Battery.

Aqueous aluminum-ion batteries (AAIBs) are considered a strong candidate for the new generation of energy storage devices. The lack of suitable cathode materials has been a bottleneck factor hindering the future development of AAIBs. In this work, we design and construct a highly effective cathode with dual morphologies.

α-MnO Cathode with Oxygen Vacancies Accelerated Affinity Electrolyte for Dual-Ion Co-Encapsulated Aqueous Aluminum Ion Batteries.

Aluminum batteries (ABs) are identified as one of the most promising candidates for the next generation of large-scale energy storage elements because of their efficient three-electron reaction. Compared to ionic electrolytes, aqueous aluminum-ion batteries (AAIBs) are considered safer, less costly, and more environmentally friendly. However, considerable cycling performance is a key issue limiting the development of AAIBs.

Carbonyl and imine conjugated frameworks for aqueous Organo-Aluminum batteries with high specific capacity and low dissolution.

Carbonyl or imine-based compounds have received a great deal of attention due to their high specific capacity and designability as cathodes for aqueous rechargeable organo-aluminum batteries. However, the inherent low conductivity and high solubility of carbonyl and imine-based compounds severely affect the cycling stability of aluminum batteries. Therefore, it is urgent to find an organic cathodes material with low solubility and good cycling performance.

Dual-Salt Mixed Electrolyte for High Performance Aqueous Aluminum Batteries.

A dual-salt electrolyte with 5 M Al(OTF) and 0.5 M LiOTF is proposed for aqueous aluminum batteries, which can effectively prevent the corrosion caused by the hydrogen evolution reaction. With the addition of LiOTF in the electrolyte, the solvation phenomenon has changed with the coordination mode of Al conversion from an all octahedral structure to a mixed octahedral and tetrahedral structure.

Roles of histone post-translational modifications in meiosis†.

Histone post-translational modifications, such as phosphorylation, methylation, acetylation, and ubiquitination, play vital roles in various chromatin-based cellular processes. Meiosis is crucial for organisms that depend on sexual reproduction to produce haploid gametes, during which chromatin undergoes intricate conformational changes. An increasing body of evidence is clarifying the essential roles of histone post-translational modifications during meiotic divisions.

Oxygen Vacancies Boosted Proton Intercalation Kinetics for Aqueous Aluminum-Manganese Batteries.

Aluminum-ion batteries have garnered an extensive amount of attention due to their superior electrochemical performance, low cost, and high safety. To address the limitation of battery performance, exploring new cathode materials and understanding the reaction mechanism for these batteries are of great significance. Among numerous candidates, multiple structures and valence states make manganese-based oxides the best choice for aqueous aluminum-ion batteries (AAIBs).

Titanium-catalyzed highly stereoselective anti-Markovnikov intermolecular hydroalkoxylation of alkynes to prepare -enol ethers.

Enol ethers are essential synthetic frameworks and widely applied in organic synthesis; however, high regio- and stereo-selective access to enol ethers remains challenging. Herein, we report a titanium-catalyzed stereospecific anti-Markovnikov hydroalkoxylation reaction of alkynes for the synthesis of -enol ethers with excellent functional group tolerance and yields. Mechanistic studies showed that the titanium coordinates with the alkyne and then an oxygen anion attacks the π-bond of the alkyne from the backside to provide a -oxygen metallation intermediate, which accounts for the high -stereoselectivity.

Expression of ACE2, TMPRSS2, and SARS-CoV-2 nucleocapsid protein in gastrointestinal tissues from COVID-19 patients and association with gastrointestinal symptoms.

Background: Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect the gastrointestinal (GI) tract in coronavirus disease 2019 (COVID-19) patients, the mechanism of GI tract injury is largely unknown. We aimed to study the potential factors that cause COVID-19 GI symptoms.

Methods: We investigated the expression and co-localization of angiotensin converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), SARS-CoV-2 nucleocapsid protein (NP), and the severity of inflammation in GI tissues from COVID-19 patients (n = 19) by immunofluorescence and histopathologic staining, and then studied their associations with GI symptoms.

High-performance MnSe-MnSe heterojunction hollow sphere for aluminum ion battery.

With its consistent thermal runaway temperature and superior capacity, aluminum ion batteries have emerged as a key area for battery development. At the moment, electrode material is the main focus of aluminum ion battery capacity enhancement. Selenide is anticipated to develop into a high-performance cathode for aluminum ion batteries, since it is a type of high energy density electrode material.

Magnesium bioactive glass hybrid functionalized polyetheretherketone with immunomodulatory function to guide cell fate and bone regeneration.

Polyetheretherketone (PEEK) is being increasingly recognized as a highly promising polymer implant in orthopaedics due to its advantageous biocompatibility, favorable processability, and radiation resistance. Nonetheless, the long-term application of PEEK implants in vivo faces challenges due to unfavorable post-implantation inflammatory and immune reactions, which result in suboptimal osseointegration rates. Hence, biofunctionalizing the surface of PEEK implants emerges as a viable strategy to enhance osseointegration and increase the success rate.

Application of triphenylphosphine organic compounds constructed with O, S, and Se in aluminum ion batteries.

Due to their high reactivity and theoretical capacity, chalcogen elements have been favored and applied in many battery studies. However, the high surface charge density and high solubility of these elements as electrode materials have hindered their deeper exploration due to the shuttle effect. In this article, organic structural triphenylphosphine is used as a molecular main chain structure, and chalcogen elements O, S, and Se are introduced to combine with P as active sites.

Interaction Mechanism between Cyano-Organic Molecular Structures and Energy Storage of Aluminum Complex Ions in Aluminum Batteries.

Aluminum ion batteries (AIBs) are widely regarded as the most potential large-scale metal ion battery because of its high safety and environment-friendly characteristics. To solve the problem of weak electrical conductivity of organic materials, different structures of cyano organic molecules with electrophilic properties are selected as the cathode materials of aluminum batteries. Through experimental characterization and density functional theory theoretical calculation, Phthalonitrile is the best cathode material among the five organic molecules and proved that the C≡N group is the active site for insertion/extraction of AlCl ions.

Spatial analysis of stromal signatures identifies invasive front carcinoma-associated fibroblasts as suppressors of anti-tumor immune response in esophageal cancer.

Background: Increasing evidence indicates that the tumor microenvironment (TME) is a crucial determinant of cancer progression. However, the clinical and pathobiological significance of stromal signatures in the TME, as a complex dynamic entity, is still unclear in esophageal squamous cell carcinoma (ESCC).

Methods: Herein, we used single-cell transcriptome sequencing data, imaging mass cytometry (IMC) and multiplex immunofluorescence staining to characterize the stromal signatures in ESCC and evaluate their prognostic values in this aggressive disease.

Novel lignin-supported copper complex as a highly efficient and recyclable nanocatalyst for Ullmann reaction.

In this work, we prepared polyhydroxylated lignin by demethylation and hydroxylation of lignin, and grafted phosphorus-containing groups by nucleophilic substitution reaction, the resulting material could be used as a carrier for the preparation of heterogeneous Cu-based catalysts (PHL-CuI-OPR). The optimal PHL-CuI-OPBu catalyst was characterized by FT-IR, TGA, BET, XRD, SEM-EDS, ICP-OES, XPS. The catalytic performance of PHL-CuI-OPBu in the Ullmann CN coupling reaction was evaluated using iodobenzene and nitroindole as model substrates under nitrogen atmosphere with DME and HO as cosolvent at 95 °C for 24 h.

Dual Protection Strategy by Constructing MXene-Coated CuSe-CuSe Heterojunction and CMK-3 Modification for High-Performance Aluminum-Ion Batteries.

The fabrication of cathode materials with ideal kinetic behavior is important to improve the electrochemical performance of aluminum-ion batteries (AIBs). Transition metal selenides have the advantages of abundant reserves and high discharge specific capacity and discharge voltage plateau, which makes them a promising material for rechargeable AIBs. It is well-known that the low structural stability and relatively poor reaction kinetics pose a considerable challenge to the development of AIBs.