Rotating Surfaces Promote the Shedding of Droplets.

Achieving rapid shedding of droplets from solid surfaces has received substantial attention because of its diverse applications. Previous studies have focused on minimizing contact times of liquid droplets interacting with stationary surfaces, yet little consideration has been given to that of moving surfaces. Here, we report a different scenario: A water droplet rapidly detaches from micro/nanotextured rotating surfaces in an intriguing doughnut shape, contributing to about 40% contact time reduction compared with that on stationary surfaces.

Preparation of Drug-Loaded Liposomes with Multi-Inlet Vortex Mixers.

The multi-inlet vortex mixer (MIVM) has emerged as a novel bottom-up technology for solid nanoparticle preparation. However, its performance in liposome preparation remains unknown. Here, two key process parameters (aqueous/organic flow rate ratio (FRR) and total flow rate (TFR)) of MIVM were investigated for liposome preparation.

Flow and Particle Modelling of Dry Powder Inhalers: Methodologies, Recent Development and Emerging Applications.

Dry powder inhaler (DPI) is a device used to deliver a drug in dry powder form to the lungs. A wide range of DPI products is currently available, with the choice of DPI device largely depending on the dose, dosing frequency and powder properties of formulations. Computational fluid dynamics (CFD), together with various particle motion modelling tools, such as discrete particle methods (DPM) and discrete element methods (DEM), have been increasingly used to optimise DPI design by revealing the details of flow patterns, particle trajectories, de-agglomerations and depositions within the device and the delivery paths.

Minocycline as adjunct therapy for a male patient with deficit schizophrenia.

The pathophysiology of schizophrenia may involve increased production of inflammatory cytokines by activated microglia. Minocycline can inhibit activated microglia and may improve secondary negative symptoms and/or cognitive functions when used as adjuvant to antipsychotics. Effects on minocycline on primary and enduring negative symptoms in deficit schizophrenia (DS) are unknown.

Bis(1,3-diethyl-benzimidazolium) tetra-bromidomercurate(II).

In the title compound, (C(11)H(15)N(2))(2)[HgBr(4)], the tetra-coordinated Hg(II) center of the complex anion adopts a distorted tetra-hedral geometry [Hg-Br = 2.5755 (8)-2.623 (11) Å and Br-Hg-Br = 103.

1-Butyl-3-(1-naphthyl-meth-yl)benzimidazolium hemi{di-μ-iodido-bis-[diiodidomercurate(II)]} dimethyl sulfoxide monosolvate.

In the title compound, (C(22)H(23)N(2))[Hg(2)I(6)](0.5)·(CH(3))(2)SO, the 1-butyl-3-(1-naphthyl-meth-yl)benzimidazolium anion lies across a centre of inversion. The dihedral angle between the benzimidazolium and naphthalene ring systems is 81.

1-Benzyl-imidazolium hexa-fluoro-phosphate-1-benzyl-imidazole (1/1).

In the title compound, C(10)H(11)N(2) (+)·PF(6) (-)·C(10)H(10)N(2), the H atom involved in protonation is disordered equally between the cation and the neutral mol-ecule. The dihedral angle between the phenyl and imidazole rings is 82.6 (2)°.